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Biomedical subjects

H Adam

Publications and source records attributed to H Adam.

At least 19 recordsLinked to original sources
PubMed1990

[Eosinophilic fasciitis (Shulman's syndrome)].

A 36-year-old man had noted a firm and painful swelling of the upper and lower limb, increasing over the previous few weeks. He had no fever, but the erythrocyte sedimentation rate was slightly increased (20 mm in the first hour). In addition there was a mild normochromic, normocytic anaemia (13 g/dl) and thrombocytosis (517,000/microliters). Gamma-globulin fraction was raised to 26%. The blood eosinophilia of 44% and the histological findings in a wedge biopsy of the lower leg (oedematous widened connective tissue septa, inflammatory infiltrate with eosinophilic granulocytes) established the diagnosis of eosinophilic fasciitis (Shulman syndrome). During oral treatment with prednisone (100 mg/d) the clinical symptoms regressed and the eosinophilia in peripheral blood disappeared. In the course of the subsequent seven months the prednisone dose was reduced gradually to 10 mg daily. But, because the symptoms did not entirely disappear the prednisone dose had to be increased temporarily for four times until there was a further, stepwise, reduction of the symptoms. But mild induration of the lower leg persisted. Maintenance treatment with prednisone, 10 mg daily, has been continued in order to avoid recurrence.

Adult↗
PubMed1990

Gastrin- and somatostatin-immunoreactive cells of the antral mucosa in patients with duodenal or gastric ulcers. An immunocytochemical study.

Gastrin- and somatostatin-immunoreactive cells in biopsies taken from the prepyloric portion of the antrum from 15 patients with duodenal ulcer, 16 patients with gastric ulcer, and a control group of 19 patients without histopathological alterations of the antral mucosa were studied using peroxidase anti-peroxidase and immunogold-silver staining methods in combination with morphometry. Numerical densities and sizes (immunoreactive areas) of the cells demonstrated were measured and compared between all three groups. Gastrin- and somatostatin-immunoreactive cells were located most frequently in the lower midzone of the gastric crypts. None of the parameters measured showed a correlation with age or sex. The group with duodenal ulcer tended to exhibit gastrin- and somatostatin-cell-hyperplasia whereas the size of both cell types remained unchanged. In comparison with the control group, the numerical density of gastrin-immunoreactive cells was significantly increased in gastric ulcer patients, whereas the numerical density of somatostatin-immunoreactive cells was decreased in this group. Immunoreactive areas of both cell types were significantly increased in patients with gastric ulcer.

Adult↗
PubMed1979

[The evidence of the chloramphenicol-sensibilisation by the usual lymphocyte transformation test (author's transl)].

As to its allergising capability Chloramphenicol holds a leading position. That's why the evidence of an existing sensibilisation is important. But there is a controversy concerning the usual lymphocyte transformation test (LTT). With the help of comparing tests (patch-test - LTT) a high rate of equal results between both the methods is shown. Thus, the efficiency of LTT basing on morphological analysing criteria, which is used for the evidence of an existing Chloramphenicol-sensibilisation seems to be proved.

Chloramphenicol↗
PubMed1979

[Results of heterologous tracheal transplants in animal experiments (author's transl)].

In the present study, 7 x 15 mm Cialit-preserved human tracheal segments were grafted to the tracheas of five 3-month old piglets. 72-120 days later, the animals were sacrificed and the grafts with proximal and distal control areas were removed. Tissues were then examined macroscopically and by light and scanning electron microscopy. We found that: (1) all grafts had taken well; (2) no animal suffered from clinical signs of respiratory obstruction or inflammation; (3) although luminal diameters of the tracheas increased from 8 mm to 22 mm, the size of the grafts remained unchanged but the resulting tracheal stenosis did not cause respiratory obstruction; (4) the graftet areas showed re-epithelialization. The nature of the re-epithelialization as well as the fate of the submucosa and tracheal cartilage will be reported in a subsequent publication.

Adult↗
PubMed1978

[Decrease of the immunodefence by halothane (author's transl)].

From thirty-two operated patients, narcotized with halothane, the PHA-stimulated rates of blastic transformation of cultivated lymphocytes were determined before and after the surgical operation. There was demonstrated a decrease of ability of the stimulation during 6--7 days. The maximum of this reaction was reached after 48 hours. We suppose that doses of halothane are inducing a decrease of immunodefence.

Halothane↗
PubMed1978

[Light and scanning electron microscopical studies of the soft palate and the tongue in Bombina variegata L (author's transl)].

The soft palate and the tongue of adult Bombina variegata L. were studied by means of light and scanning electron microscopy. In the palate numerous taste-disks were found prominent by their polygonal surface structures. These are caused by longer microvilli at the margins of the different cells of the taste-disk or by deepened margins of the polygonal cells. The surfaces of the cells are slightly convex and are covered by numerous microvilli. In the tongue primarily fungiform papillae were observed (with the exception of the margins were taste-disks similar to those found in the palate were present). Their taste-disks also present polygonal structures, their epithelial cells are characterized by microridges while those of the epithelial folds surrounding the fungiform papillae own microvilli. As special formations within the taste-disks small knob-like protrusions between polygonal cells were found.

Animals↗