[Emergency application to a psychiatric admission department. A 1-year report].
Explore the source record for details and available documents.
Adolescent↗
Biomedical subjects
H Aggernaes
Publications and source records attributed to H Aggernaes.
Dexamethasone suppression test and TRH test in endogenous depression.
Dexamethasone suppression test (DST) and thyrotropin releasing hormone (TRH) stimulation test were performed in 34 patients with endogenous depression. Compared with 33 psychiatric controls (limit of discrimination for serum cortisol of 275 nmol/l = 10 micrograms/100 ml) the specificity of the DST was 91% and the sensitivity was 65%. Compared with 24 healthy subjects the sensitivity of the TRH test was 24%, and the combined sensitivity for the DST and the TRH test was 76%. In contrast to the TRH test the DST showed a significant relationship (r = 0.54, P less than 0.01) to the Hamilton Rating Score. Repeating the tests after clinical recovery parallel changes of the two tests were found in 14 of 19 patients with abnormal DST in the depressed phase. In the remaining five patients the DST normalized, while the TRH test remained unchanged. It is suggested that both the apparent higher diagnostic sensitivity and the higher rate of normalization after clinical recovery of the DST is due to the dependency of the severity of depression.
Adolescent↗
Circadian variation of serum thyrotropin in endogenous depression.
The circadian variation of serum thyrotropin (thyroid-stimulating hormone; TSH) was studied in nine patients with endogenous depression before and after recovery. Depressed state did not appear to influence the pattern of TSH. When 2 mg of dexamethasone was administered, serum TSH was significantly reduced for 18 hours, whereafter the effect leveled off. The TSH response to thyrotropin-releasing hormone (TRH) was evaluated 25 hours after the administration of dexamethasone and the response was found to be unchanged.
Aged↗
The histamine test in schizophrenia.
The cutaneous response to intradermal injection of 50 micrograms of histamine was studied in nonmedicated schizophrenic patients, schizophrenic patients treated with neuroleptic drugs, nonschizophrenic patients receiving neuroleptics, and nonmedicated controls. The diminished response previously reported in schizophrenic patients was not reproduced. Thus, the histamine test does not appear to be useful in diagnosing schizophrenia.
Adult↗