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H Akan

Publications and source records attributed to H Akan.

At least 91 records · Page 5Linked to original sources
PubMed1994

An evaluation of the condylar position of the temporomandibular joint by computerized tomography in Class III malocclusions: a preliminary study.

The position of the condyle within the glenoid fossa was investigated in 21 adult patients with untreated skeletal Class III relationships and 18 adult patients with normal occlusions as controls. Axial computerized tomography (CT) was used for precise measurements of the bony structures of the temporamandibular joints. In horizontal sections, the mediolateral dimensions of the condyles of the patient group were found to be statistically higher in the fossa. The anteroposterior glenoid fossa dimensions were found to be smaller in Class III malocclusions. The smaller anterior joint space dimensions in the Class III relationships were also found to be statistically significant. The analysis of the measurements suggests that relative condylar protrusion with a relative mediolateral elongation of the condyle within a relatively smaller glenoid fossa are correlated with the anterior mandibular displacement in skeletal Class III malocclusions.

Adult↗
PubMed1994

Peripheral T cell receptors alpha beta and gamma delta in patients with Hodgkin's lymphoma.

Antigen recognition by T cells is determined by an antigen specific T cell receptor (TCR). Two heterodimeric TCR structures associated with CD3 have been defined: TCR alpha beta and TCR gamma delta. TCR alpha beta and its function are well described but the role of TCR gamma delta in normal and lymphoproliferative disorders is not well established. In newly diagnosed or relapsed/refractory Hodgkin's disease (HD), a disease associated with defective T cell functions and increased sIL-2R, we determined levels of seven TCR alpha beta variable regions [beta V5(a), beta V5(b), beta V6(a), beta V12(a), alpha beta V(a), alpha V2(a)] and TCR gamma delta by using monoclonal antibodies (MCA). TCR gamma delta levels did not show any difference, but several variable regions of the TCR alpha beta differed when groups are compared with each other and the control group.

Adolescent↗
PubMed1994

Neonatal cerebral candidiasis: CT findings and clinical correlation.

Lumbar puncture in a premature newborn undergoing therapy for sepsis revealed meningitis. Contrast-enhanced cranial tomography revealed multiple, homogeneously or ring-like enhanced lesions with peripheral edema. Cerebrospinal fluid culture showed growth of candida. Significant clinical recovery after Amphotericin-B treatment was noted. Follow-up CT examination showed regression of the lesions. Five months later no pathology was reported except small calcified granulomas and an area of encephalomalacia.

Amphotericin B↗
PubMed1993

The diagnostic value of cranial computed tomography in complicated eclampsia.

Cranial CT scanning was performed in twenty-two patients with severe neurological complications secondary to eclampsia. All patients had repetitive and/or prolonged convulsions. In addition, three patients were in prolonged coma, and three had cortical blindness. One of the patients had central facial paresis, and two had hemiparesis. In seventeen patients, abnormal CT findings were identified. Diffuse cerebral edema was determined in four patients. The most frequent finding was bilateral low-density areas in the parietal and/or occipital lobes (7 cases). In three patients, CT revealed bilateral low-density areas in the basal ganglia. All women but three recovered completely. Two of the three patients who died had intracranial massive hemorrhage. Follow-up CT examinations demonstrated complete resolution of the low-density areas and slight cortical atrophy in three of four patients. Complete recovery of the patients associated with complete resolution of the low-density lesions suggested that these lesions corresponded to edema. We concluded that CT is useful in patients with complicated eclampsia because it may orientate management.

Brain↗
PubMed1993

The clinical correlations of serum tumor necrosis factor-alpha in acute leukemias: a predictor of response and relapse?

The clinical correlations of serum tumor necrosis factor alpha (TNF-alpha), a cytokine which can be released from leukemic blasts, has not been extensively studied. We have analyzed serum TNF-alpha in 20 ANLL, one CML-myeloblastic crisis, and 14 ALL adult patients by using a commercial ELISA kit. Sterile serum samples were taken on day 0, day 7, during remission and relapse with a mean follow-up period of 4.2 (1-19) months. After a median of 7 days following chemotherapy, serum TNF-alpha decreased both in responding ANLL (p = 0.004) and ALL (p > 0.05) but remained high in refractory leukemias. Values on day 7 were significantly different between responding and refractory patients in both ANLL (p = 0.0027) and ALL (p = 0.0099). At relapse, serum TNF-alpha increased starting at a median of 3 months preceding clinical symptoms in ANLL (p = 0.002). However, the relapse of ALL coincided with a slight increase which was not significant (p > 0.05). Together these findings indicate that serum TNF-alpha can be used as an early predictor of clinical response and relapse in ANLL.

Acute Disease↗
PubMed1992

P-glycoprotein expression in refractory hematological neoplasms and circumvention of resistance with verapamil or cyclosporine A containing protocols.

Either p-glycoprotein (pgp) or the encoding gene mdr1 expression has been reported to be correlated with multidrug resistance and poor treatment response. To investigate the incidence of pgp in refractory hematological neoplasms we analyzed malignant cells from 40 patients by an immunoperoxidase method using the monoclonal antibody C219. Pgp was positive in 75% of acute nonlymphoblastic leukemia (ANLL) and 50% of acute lymphoblastic leukemia (ALL). Pgp positivity was similarly distributed in both Tdt (-) and (+) ANLLs (64% versus 100%). Addition of Verapamil (VRP) (12 patients) or Cyclosporine A (CsA) (7 patients) to the previous chemotherapy protocol resulted in complete response in 7 (58%) and 3 (43%) of the patients respectively. Partial response was observed in one patient who received CsA. Both chemosensitizers were tolerated well with few reversible side effects. The preliminary results of this study have been presented in the 15th International Cancer Congress, August 1990 Hamburg, Germany.

ATP Binding Cassette Transporter, Subfamily B, Mem↗
PubMed1991

Sialographic and ultrasonographic analyses of major salivary glands.

Seventy patients with major salivary gland diseases (60 parotis, 10 submandibular) were examined both with sialography and ultrasonography. The clinical and histopathological results were compared with radiological interpretations. Sialography was found to be 60% accurate for the diagnosis of salivary gland tumors and cysts and 63% for the diagnosis of inflammatory diseases. Ultrasonography diagnosed 95% of the tumors and 63% of inflammatory diseases accurately.

Adolescent↗
PubMedDate not supplied

Two-dimensional ultrasonographic findings of atelectatic lung segments.

Thirteen cases with pulmonary atelectasis were examined by two-dimensional sonography in our clinics between October 1990 and April 1993. Patients' ages ranged from 2 to 16 years. Five patients revealed atelectasis with pleural effusion and eight patients had only atelectasis. Two-dimensional sonography showed a solid mass indistinguishable from lung parenchyma in patients with atelectatic lung segment without pleural effusion while atelectatic segment was readily identified in those with pleural effusion. We conclude that sonography is a useful and non-invasive technique in differentiating cardiac from extracardiac masses, because atelectatic lung segment with moderate to large pleural effusion may mimic intrapericardial masses.

Adolescent↗