Biomedical subjects

H Aldskogius

Publications and source records attributed to H Aldskogius.

129 records · Page 8Linked to original sources

PubMedDate not supplied

Invasion of cranial nerves and brain stem by herpes simplex virus inoculated into the mouse tongue.

Herpes simplex virus type 1 (HSV) of a highly or slightly neuropathogenetic strain was inoculated into the tongues of mice. After appropriate survival times, the animals were killed and portions of the facial and trigeminal nerves as well as the brain stem were examined with virus isolation and immunocytochemistry for the presence of HSV. Both virus strains were demonstrated in the geniculate and trigeminal ganglia and in the CNS portion of the facial and trigeminal nerves, as well as in various brain stem areas including the trigeminal tract and nucleus, the facial and hypoglossal nuclei, and nuclei in the reticular formation. The results indicate that HSV is transported to the CNS by efferent and afferent axons of the tongue and subsequently via transneuronal passage to various brain stem nuclei. These findings provide an anatomic basis for a putative relationship between HSV and cranial nerve dysfunction.

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PubMedDate not supplied

Distribution of sensory ganglion cells innervating facial muscles in the cat. An anatomical study with the horseradish peroxidase technique.

The question of a possible sensory component in branches of the facial nerve innervating facial mimetic muscles in the cat was examined by the technique of retrograde axonal transport of horseradish peroxidase (HRP). HRP was applied to the proximal cut end of facial nerve branches innervating different facial muscle groups. Following survival periods of 71-75 h the animals were fixed by perfusion. Certain craniospinal sensory ganglia and the brain stem were processed histochemically for demonstration of HRP. HRP-labelled cell bodies, structurally resembling sensory neurons, were consistently observed ipsilaterally in the geniculate and proximal vagal ganglia and under certain conditions in the trigeminal ganglion. Measurements of HRP-labelled neurons in the geniculate and proximal vagal ganglia showed a wide size range but a unimodal size distribution with peaks in the small size range. These findings support the view that facial nerve branches innervating the mimetic muscles contain different types of sensory fibers.

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PubMedDate not supplied

Motor fibre organization in the intratemporal portion of cat and rat facial nerve studied with the horseradish peroxidase technique.

The intra-axonal transport of horseradish peroxidase (HRP) was used to label fibres in the intratemporal facial nerve portion (ITFN) in the rat and cat. HRP was applied to the proximal cut end of facial nerve branches innervating different facial muscles. Following appropriate survival periods, the animals were fixed by perfusion. The ITFN was processed histochemically for demonstration of intra-axonal HRP, using tetramethylbenzidine as substrate. The distribution of labelled fibres was analyzed in serial longitudinal sections and in photographic transverse-like reconstructions from three selected levels. HRP-labelled fibres from all examined motor branches were found to be diffusely distributed almost throughout the entire ITFN, leaving only a narrow zone free of label. By applying HRP to the chorda tympani nerve, it was shown that this zoe harbours fibres of this nerve. The findings support the conclusion that the motor fibres to the facial muscles are diffusely organized in the ITFN.

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