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Biomedical subjects

H Alper

Publications and source records attributed to H Alper.

At least 37 records · Page 2Linked to original sources
PubMed1999

Isolated pontine infarction due to rhinocerebral mucormycosis.

We report a patient with rhinocerebral mucormycosis whose initial central nervous system involvement was isolated pontine infarction due to basilar arteritis caused by the fungus. The patient was diagnosed and followed by MRI and CT and basilar arteritis was demonstrated well on MRI studies. Involvement of the skull base was shown on CT in the later stage of the disease. The unusual initial presentation of the infection is discussed.

Adult↗
PubMed1999

Varix of the inferior pulmonary vein: computed tomography and magnetic resonance angiography findings.

A 37-yr-old male presented with a 2-week history of intermittent episodes of mild haemoptysis. Computed tomography and magnetic resonance imaging revealed a varix of the inferior pulmonary vein. The diagnosis was confirmed using magnetic resonance angiography and conventional angiography. This condition is relatively rare, and few cases have previously been demonstrated by means of magnetic resonance imaging and angiography.

Adult↗
PubMed1999

An unusual pulmonary perforation case after chest tube placement.

Pulmonary laceration is an uncommon complication of tube thoracostomy technique that is expected vigorous clinically and may be fatal. In this study, we report a case of pulmonary laceration owing to a tube thoracostomy, with no clinical signs, and detected incidentally on thorax computed tomography.

Adult↗
PubMed1998

CT bronchus sign-guided bronchoscopic multiple diagnostic procedures in carcinomatous solitary pulmonary nodules and masses.

CT bronchus sign (BS) designates a bronchus leading directly to a peripheral pulmonary lesion. The objective of this investigation is to determine the contribution of BS-guided bronchoscopic multiple diagnostic procedures (BMDPs) to the diagnostic yield of solitary nodules or masses (SPNMs) suspected of pulmonary carcinoma (PC). A prospective study was carried out in 92 patients with a 2-5 cm diameter SPNM at the level of third to fifth bronchial branching and without endobronchial tumors. Within 10 days after 2-mm CT scans were done, in each of 92, bronchial washing (BW), brushing (BR), transbronchial needle aspiration (TBNA) and transbronchial lung biopsy (TBB) were performed respectively, via fiberoptic bronchoscopy (FB) under fluoroscopic guidance. In 40 (82%) of 49 with BS and in 19 (44%) of 43 without BS, FB established the diagnosis (p < 0.01). In 84 cases of PC, BW, BR, TBNA and TBB provided the diagnostic yields of 4% (3), 26% (22), 57% (48) and 49% (41), respectively; the combined yield reached 68% (57). A metastasis and a tuberculoma were diagnosed exclusively by TBB, and TBNA, respectively. All differences of diagnostic yield except that between TBNA and TBB (p > 0.05) were determined to be significant (p < 0.05). Thoracotomy verified diagnosis in 48 of 59 cases diagnosed and 19 of 33 undiagnosed by FB, and various tissue biopsies or clinical follow-up in 11 diagnosed and 14 undiagnosed by FB. The above data suggest that in the diagnosis of PC as a SPNM at the level of third-fifth bronchial branching, combining the guidance of CT BS, and BMDPs under fluoroscopic guidance can increase the yield considerably.

Adult↗
PubMed1998

Cervical osseous changes associated with vertebral artery tortuosity.

Vertebral artery tortuosity causing neural foraminal widening is a well described abnormality that should not be confused with other causes of neural foraminal enlargement, particularly on conventional roentgenograms. We, hereby, describe CT features of another cervical osseous change due to the vertebral artery tortuosity, the so called "tubular shaped vertebral artery canal", which is embedded in the vertebral body instead of causing neural foramen enlargement. Catheter and MR angiographic studies have also been performed to confirm the vertebral artery tortuosity causing the osseous changes.

Adult↗
PubMed1998

Retroclival epidural hematoma secondary to decompressive craniectomy in cerebellar infarction: MR demonstration.

Epidural hematomas of the clivus are very uncommon. We, hereby, present a case of retroclival epidural hematoma as a complication of posterior fossa decompressive surgery for the management of acute cerebellar infarction. Serial MRI examinations of the patient was documented and demonstrated. In addition, the etiology of retroclival epidural hematomas were also discussed.

Adult↗
PubMed1996

Bilateral synovial coracoclavicular joints: MRI demonstration.

Bilateral coracoclavicular joints, an anatomical variation, are described by radiography and MRI. MRI enabled precise identification of the nature of these joints. They were true synovial joints with cartilage and synovial fluid. To the best of the authors' knowledge, this is the first demonstration of such joints by MRI.

Aged↗
PubMed1996

Pulmonary aplasia: MR angiography findings.

A 26-year-old woman presented with absence of the left lung. A diagnosis of pulmonary aplasia (main bronchus ending in a blind pouch) was established by bronchoscopy. Although a CT scan and MR imaging suggested the correct diagnosis, MR angiography enabled optimal demonstration of the vascular changes due to the anomaly (single main pulmonary artery and vein) and an associated anomaly (azygous continuation of the inferior vena cava).

Adult↗
PubMed1996

Drug-membrane interactions studied by molecular dynamics simulation: size dependence of diffusion.

Bioavailability, largely due to membrane permeation, is an important step in the drug delivery process and therefore drug design. In this study, a series of molecular dynamics simulations (totaling 10's of nanoseconds) of small molecules (varying in size, and functional groups) in lipid bilayer membranes were used to elucidate the mechanism of diffusion of drugs within biomembranes. These simulations accurately reproduce many experimentally observed parameters. The simulations also agree with theory that indicates the lipid bilayer has internal structure that influences the diffusion process and that even within the hydrocarbon regions there are distinct regions between which the rate and mechanism of diffusion varies. In particular, in agreement with experiment and theory the small solutes were found to diffuse by a mechanism different from that of large molecules. These variations are linked to the frequency and size of spontaneously arising voids within the bilayer as well as the rate of torsional isomerization of the hydrocarbon chains.

Biological Availability↗
PubMed1996

Tuberculous radiculomyelitis as a complication of spondilodiscitis: MR demonstration.

We present the MRI features and follow-up results in a case of acute tuberculous (TB) radiculomyelitis adjacent to spondilodiscitis in the thoracic spine. Medullary involvement by tuberculosis originating by different mechanisms have been demonstrated in the recent literature. However, this rare complication accompanying TB spondilodiscitis has not been reported.

Adult↗
PubMed1994

Petrous apex mucocele: high resolution CT.

Mucocele of the petrous apex is very rare, only three cases having been reported. Since this area is inaccessible to direct examination, imaging, preferably high resolution computed tomography (HR CT) is essential. We report a case showing an eroding, non enhancing mass with sharp, lobulated contours, within the petrous apex. The presence of a large air cell on the opposite side suggested a mucocele.

Abducens Nerve↗
PubMed1991

Retroperitoneal part of the femoral nerve. Normal ultrasound features.

The retroperitoneal part of the normal femoral nerve has been studied in 34 healthy subjects with ultrasound (US) to evaluate its course, thickness and anteroposterior diameter. A correlative cadaver study was also undertaken; a cadaver was scanned during dissection, and 12 cadavers were studied macroscopically to evaluate the length of the retroperitoneal part of the nerve. Because the femoral nerve could be well seen in its course in the retroperitoneum with US, it is suggested in this study which--to the authors' knowledge--is the first report on imaging of the femoral nerve, that sonography may serve as an initial imaging tool to detect lesions of the nerve itself as well as lesions adjacent to it.

Adolescent↗
PubMed1991

Familial bilateral glomus jugulare tumors.

Glomus jugulare tumors may be bilateral or more commonly associated with a glomus tumor in another location. These tumors can also have a familial distribution which appears to be autosomal dominant. In this paper, two brothers are presented with bilateral glomus jugulare tumors. Such occurrence appears to be a unique familial manifestation.

Adult↗