Biomedical subjects
Publications and source records attributed to H Amigues.
The authors report a case of a gastric involvement by a multiple myeloma, suspected on ultrasonography although the gastric endoscopy was normal. The barium examination and the CT scan agreed with the ultrasound hypothesis confirmed by histology.
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In order to determine the endocytic ability and metabolic capacity of polymorphonuclear neutrophils, 45 patients with rheumatoid arthritis were compared with a series of control subjects. Two in vitro tests were performed in each patient: the phagocytic index (Brandt's technique) and the nitro-blue tetrazolium reduction test (Braehner & Nathan's technique). These two tests show a significant decrease in comparison with controls, the NBT reduction being modified only in stimulated leukocytes. This finding, in contrast to previously reported studies based on different techniques, underlines the existence of a functional modification of blood polymorphonuclear neutrophils in rheumatoid arthritis.
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The authors looked for Australia antigen in a population of 578 rheumatic patients, 300 of whom were polyarthritic, by electrosyneresis and complement fixation methods. Australia antigen was found in 26 patients, and anti-Australia antibodies in 33 patients. Most of these patients were suffering from rheumatoid polyarthritis--22 presented hepatic disturbance, and 28 had undergone surgical operations, blood transfusions, and repeated hospitalization. The presence of Australia antigen did not in any case appear to play a role in the development of the lesions, apart from the occurrence of signs of hepatic lesions, but appeared to be an indicator of a form of hospitalization.
The authors demonstrated in the urine of certain patients a peptide form of hydroxyproline and of glutamic acid. This peptide was found in patients with Paget's disease who presented clinical and laboratory signs of an evolutive episode and in other patients who presented restructuration of bone of a radiologicaly type. This peptide was one of the factors determining the increase in the total hydroxyprolinuria. The demonstration of the peptide provokes discussion as to its origin, and also of the possibility of using it as a biochemical parameter.
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In making a comparative study of different parameters in the examination of synovial fluid (rheumatoid factors, ragocytes, leucocytes, synovial complement, immunoglobulins) the authors show that rheumatoid fluid has characteristics that make differentiation from other inflammatory arthropathies possible on a statistical basis, thanks to the test for the homogeneity of the means. The presence of these characteristics seems to constitute a diagnostic argument which can be measured by mathematical methods.
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