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Biomedical subjects

H Andrup

Publications and source records attributed to H Andrup.

11 recordsLinked to original sources
PubMed1989

[Early resuturing after abdominal wound infection under prophylactic metronidazole and ampicillin].

A randomized double-blind investigation was undertaken to assess the effect of treatment with metronidazole and ampicillin in patients with subcutaneous wound infection after laparotomy and early resuture. The wounds were closed in the fourth day and the antibiotic cover lasted from one to four days. None of the patients developed signs of sepsis or new abscesses. All of the wounds healed primarily but there were slight defects in two patients. These did not require surgical treatment. It is concluded that early closure of infected wounds after laparotomy may be undertaken under metronidazole and ampicillin cover and that treatment for one day is sufficient.

Ampicillin↗
PubMed1989

[Myocardial enzymes in the serum after high and low laparotomy].

The serum activities of ASAT, ALAT, LDH, creatine kinase (CK) and creatine kinase B (CK-B) were measured perioperatively in 20 patients in connection with vagotomy or subtotal/total gastrectomy and in 20 patients in connection with resection of the rectum. None of the patients presented clinical or serial electrocardiographic signs of acute myocardial infarction (AMI). ASAT, ALAT and LDH showed moderate increases postoperatively, the median values of which were within the reference range, and no statistical differences were found between the maximal values for these enzymes between patients with high and low laparotomies. In both patient categories, CK and CK-B showed marked postoperative increase and the maximal values for these enzymes were significantly higher in the group of patients subjected to high laparotomies, presumably on account of more pronounced muscle trauma in this group. The discriminative limits for CK-B as regards AMI diagnosis usually employed were found to be unsuitable after stomach and rectum surgery. The traditional myocardial enzymes must be interpreted with restraint after laparotomy as regards the diagnosis of AMI. A discriminative limit for CK-B% (maximal CK-B/total CK) of 6 is probably more suitable.

Adult↗
PubMed1989

[Secondary aorto-enteric fistula].

On the basis of five case histories, the causes, symptoms, investigations, diagnosis and treatment of secondary aorto-enteric fistulae are reviewed. In a patient in whom reconstruction in the aortoiliac segment has been undertaken, recurrent haematemesis and melaena, pyrexia and septicaemia and abdominal pain should lead to investigation for aorto-enteric fistula by means of oesophagogastro-duodenoscopy and radiological investigations if the condition permits this. Otherwise, emergency laporotomy with thorough examination of the intestine should be undertaken. The condition is associated with a considerable mortality but the prognosis is improved by rapid intervention. In cases where aorto-enteric fistula is suspected, the patient should be referred to a department for vascular surgery.

Aorta, Abdominal↗
PubMed1989

Management of severe incisional abscesses following laparotomy. Early reclosure under cover of metronidazole and ampicillin.

Patients developing severe incisional abscesses following laparotomy were treated with incision and drainage followed by early reclosure under antibiotic cover with metronidazole and ampicillin anhydricum. Patients with subcutaneous abscesses were randomized into two groups that were treated with antibiotics for one day (n = 23) or four days (n = 27). These patients all underwent reclosure four days later. In a third group of patients (n = 14) abscesses had developed down to, but not through, the peritoneum. These patients received antibiotic treatment for four days and underwent reclosure a mean of 5 1/2 days later (range, four to eight days). No abscesses reappeared in any group and all wounds healed by first intention. Five patients healed totally, with minor defects, but there was no need for surgical intervention. We conclude that the early reclosure technique is a safe procedure under antibiotic cover with metronidazole and ampicillin. One day and four days of antibiotic treatment are equally safe in patients with subcutaneous abscesses.

Abscess↗
PubMed1988

Primary linitis plastica of the small bowel. Case report.

Linitis plastica carcinoma of the gastrointestinal tract is rare. No case with origin in the small intestine has been reported in the available literature. A 29-year-old man with vague abdominal symptoms and bilateral inguinal lymphadenopathy was found to have primary linitis plastica of the ileum. The prognosis is poor.

Adult↗