Biomedical subjects

H Anton

Publications and source records attributed to H Anton.

16 recordsLinked to original sources

PubMed2000

Certification and measuring competency in physical medicine and rehabilitation in Canada.

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Canada↗

PubMed1999

Origin of renewed spinal ganglia during tail regeneration in urodeles.

The source of the cells which form the spinal ganglia within the regenerating urodele tail is not yet indisputably known. Classical and modern experimental approaches trace the spinal cord as the most probable source. The aim of the present study was to further investigate this item by conventional histology, counting of mitotic figures, and estimating the labeling index. The main results can be summarized as follows: (a) The regenerated part of the tail contained only two bilaterally asymmetrical pairs of ganglia, with respect to the rostrocaudal (anterior-posterior) axis. (b) The anterior ganglia were slightly differentiated and appropriately localized; therefore, analysis was performed mainly in the posterior, still developing ganglia. (c) An anatomical continuation between the ventrolateral side of the regenerated spinal cord and the laterally forming spinal ganglion was noticed. There was some indication that many cells migrated out from the spinal cord towards the spinal ganglion, through the ventral root. (d) The mitotic and the labeling index along the regenerated spinal cord exhibited individual peaks near the level of each developing ganglion. The last two observations corroborate and reinforce the prevailing view that the progenitors of the spinal ganglion cells which are formed in the regenerating tail are of spinal cord origin.

Animals↗

PubMed1998

Hemodynamics of stroke patients under therapy with low molecular weight hydroxyethyl starch.

In stroke penumbra perfusion depends passively on hemodynamics. So far hemodynamic effects of low molecular weight hydroxyethylstarch (HES) has not been investigated. Ten stroke patients received hypervolemic HES therapy. Cardiac output and heart rate were monitored using the bioimpedance method, blood pressure by conventional measurement. The Scandinavian Stroke Scale assessed clinical outcome. Circadian cardiac output changes were measured in 20 controls. Patients' cardiac output increased after the loading dose (5.3 +/- 1.4 l min(-1) to 6.5 +/- 1.7 l min(-1), p < 0.01), fluctuating then between 5 and 7 l min(-1) without nocturnal decrease. Beside an initial increase, the heart rate showed, like blood pressure, no remarkable changes. The Scandinavian Stroke Scale score did not change significantly. The controls showed a circadian cardiac output fluctuation (2.00 am, 5.3 +/- 0.3 l min(-1); 8.30 am, 8.1 +/- 0.6 l min(-1). Our patients showed a hemodynamic and clinical stabilization under therapy with low molecular weight HES. The physiological nocturnal decrease of cardiac output and blood, which might cause clinical deterioration in stroke patients, was avoided.

Adult↗

PubMed1998

Serine/threonine protein phosphatases type 1, 2A and 2C in vertebrate retinae.

A number of retinal proteins are phosphorylated by a variety of kinases, resulting in well-known regulatory effects. The identity and role of corresponding phosphatases is less clear. We simultaneously measured the activity of serine/ threonine protein phosphatases type 1, 2A and 2C in bovine retinae. The enzymes were classified according to substrate specificity, divalent cation requirement and the effect of phosphatase subtype-specific inhibitors. The total- and specific activity of phosphatase type 2A was prevalent. Type 2C was 10-fold less abundant. 80% of type 1 and 50% of type 2A and type 2C, respectively, were soluble. An economic purification scheme was developed. We demonstrated the presence of phosphatase isozymes 2Calpha and 2Cbeta in bovine rod outer segments by enzymatic analysis as well as immunological techniques. The results suggest a yet unknown role of phosphatase type 2C in phototransduction. On the other hand, the immense amount of protein phosphatases found to be soluble - therefore not associated with rod outer segment membranes - points towards participation of these enzymes in the process of visual transduction not considered thus far.

Animals↗

PubMed1991

Urodynamic assessment and lateral urethrocystography. A comparison of two diagnostic procedures for female urinary incontinence.

We compared urodynamic findings and results of lateral urethrocystography in 84 case. The aim of the study was to establish a possible correlation between anatomic findings and functional results. Clinically, a significantly greater increase in the normal axis of urethral inclination was noted in patients with a urodynamic diagnosis of stress incontinence than in patients with urge incontinence or for normal urodynamic findings. Lateral urethrocystography vis-à-vis urodynamic assessment proved to be a method having high sensitivity (91%) but low specificity. These two methods supply different but complementary data. Together with the patients' medical history, the assessment of their complaints, clinical vaginal examination, and clinical stress test, they offer valuable information for an efficient therapeutic concept.

Adult↗

PubMed1981