PubMed Health⌕ Search

Biomedical subjects

H Asaba

Publications and source records attributed to H Asaba.

At least 37 records · Page 2Linked to original sources
PubMed1989

Motor learning in ideomotor apraxia.

Using Luria's motor sequence test, we studied the learning ability of 34 right-handed patients with unilateral hemisphere lesions. Patients with ideomotor apraxia needed 4 to 6 trials in the test, while the remainder needed only 1 or 2. Ideomotor apraxics also required more time to complete the test. The lesions of patients who failed to master this test were not always found in the frontal lobes. These results suggest that the ability to learn motor sequences is impaired in apraxic patients and that the left hemisphere of the brain plays the major role in learning a new motor sequence. Patients with ideomotor apraxia are impaired not only when performing previously learned motor tasks but also when learning a new motor task.

Aged↗
PubMed1988

Neuropsychological and neuropsychiatric findings in right hemisphere damaged patients.

We evaluated 46 patients with right hemisphere strokes for unilateral spatial neglect (USN), anosognosia, hemiasomatognosia, extinction, constructional disturbance, motor impersistence and organic mental syndrome. High correlations were found among the incidences of USN, anosognosia, hemiasomatognosia, extinction, motor impersistence and constructional disturbance. USN, hemiasomatognosia, motor impersistence, constructional disturbance and anosognosia tended to occur with large lesions. Organic personality syndrome was frequent (33%) and was more often associated with USN, anosognosia, hemiasomatognosia, extinction, constructional disturbance and motor impersistence than other psychiatric symptoms.

Aged↗
PubMed1985

Evaluation of impedance technique for fluid-volume monitoring during hemodialysis.

Fluid-volume changes during hemodialysis were studied in 30 patients at four separate treatments in each patient. Readings of fluid-volume changes obtained by a fluid-balance monitor with non-invasive tetrapolar impedance technique were compared to changes in weight caused by the treatment. A correlation coefficient of r = 0.90 (p less than 0.001) was found. A survey of papers describing impedance measurements during hemodialysis or diuresis is also presented.

Adult↗
PubMed1985

On drug artifacts in middle molecule analysis.

In a retrospective study of 58 nondialyzed uremic patients, artifacts originating from furosemide, methyldopa, hydralazine, allopurinol and beta-blocking agents on determination of plasma middle molecules could not be substantiated. Furosemide administration did not have any influence on middle molecule determination in hemodialysis patients. The salicyclic acid administration in normal subjects resulted in increased urinary excretion of fraction 7c; the role of salicylic acid needs to be further investigated.

Furosemide↗
PubMed1983

Hemodialysis in the treatment of chronic schizophrenic patients: a double-blind crossover study.

In order to examine the reported beneficial effects of hemodialysis in chronic schizophrenic patients, a double-blind crossover study was carried out. Of the 47 patients considered for treatment, 10 diagnosed as chronic schizophrenics according to the Feighner and DSM-III criteria were accepted to the study. Seven of these patients completed the full program, four of whom belonged to a large family with a high incidence of schizophrenia. All patients were on antipsychotic medication throughout the study. Psychopathological evaluations were performed regularly in a blind fashion using the Comprehensive Psychopathological Rating Scale (CPRS) and the Nurse Observation Scale for Inpatient Evaluation (NOSIE-30). Samples of blood, urine, cerebrospinal fluid, and dialysate were obtained for examination. Three patients improved during active dialysis and two patients improved during sham treatment. Improvement in the five patients took place during the first treatment period. This study failed to demonstrate a therapeutic effect of hemodialysis superior to the sham procedures.

Adult↗
PubMed1983

Levomepromazine elimination in patients during active and sham hemodialysis.

The effect of active and sham dialysis on the plasma concentration of levomepromazine was studied in seven schizophrenic patients undergoing hemodialysis treatment in a double-blind crossover study. Samples of blood were collected before, after 2 h and 5 h of treatment, and once a week during the treatment program. The plasma concentrations decreased during both active and sham dialysis. The data indicate that there was no significant difference in the elimination of the drug between active and sham hemodialysis.

Adult↗
PubMed1983

Serum lipids and lipoproteins in schizophrenic patients with normal renal function treated with hemodialysis.

To study the effect of hemodialysis on serum lipids and lipoproteins, five patients with normal renal function who had undergone hemodialysis for schizophrenic symptoms for 10 weeks in a crossover study were investigated. Active or sham (no dialysate flow through the filter) dialysis was instituted randomly. Serum lipids were isolated by ultracentrifugation and precipitation before and after each period. High density lipoprotein (HDL) cholesterol levels were constantly low and correlated negatively with serum alkaline phosphatase concentrations (p less than 0.05). Serum and very low density lipoprotein (VLDL) triglycerides and VLDL cholesterol increased during active, and to a lesser extent during sham, dialysis. Dialysis of this intensity does not affect HDL. The low levels may be secondary to subclinical cholestasis from neuroleptic drug treatment. Some individuals may develop hypertriglyceridemia of unknown pathogenesis during hemodialysis. Both these lipoprotein abnormalities are risk factors for the development of atherosclerosis.

Adult↗
PubMed1983

Assessment of hemolysis in regular hemodialysis patients by measuring carbon monoxide production rate.

In 17 patients requiring regular hemodialysis, inter- and intradialytic hemoglobin catabolism measured as endogenous carbon monoxide production (VCO) were studied before (9 patients) and after (8 patients) the introduction of water treatment. Before the water treatment, VCo increased significantly from inter- to intradialytic periods whereas insignificant changes were noted after the water treatment. Thus water treatment leads to less destruction of erythrocytes in connection with hemodialysis. However, hemolysis associated with hemodialysis does not play a major role as a cause of anemia in these patients.

Adult↗
PubMed1983

Accumulation and excretion of middle molecules.

The accumulation and excretion of uremic middle molecules (MM) were assessed in 97 non-dialyzed azotemic patients with varying degrees of renal insufficiency. For comparison the excretion rates of MM were estimated in 12 normal subjects. By the use of combined gel filtration and ion exchange gradient elution chromatography the U-V absorbing fractions (7a, 7b, 7c, 7d, 7e, 7f and 7g) with middle molecular characteristics were isolated and quantified in uremic plasma. Accumulation of MM in sufficient quantities to be measured in the analytical system occurred only in patients with advanced renal failure with endogenous creatinine clearance below 11 ml/min. These MM fractions were either undetectable or present in trace quantities in the plasma of normal individuals. The excretion rates of certain MM (fractions 7c and 7f) were higher in uremic patients than in normal subjects, suggesting that the accumulation of these fractions occurred as a consequence not only of reduced urinary excretion but also of the enhanced production rate. The excretion rates of other fractions (7a, 7b and 7g) were of the same magnitude in uremic patients as in normal individuals. Renal clearances of the MM fractions were equal to or higher than endogenous creatinine clearance.

Adolescent↗
PubMed1983

Clinical implications of uremic middle molecules in regular hemodialysis patients.

Sixty-five regular hemodialysis patients, maintained on stable dialysis schedules for at least one month, were investigated to assess the relationship between uremic morbidity and the accumulation of individual middle molecule fractions (MM). Pre-dialysis plasma levels of MM were determined by the use of gel chromatography followed by ion exchange gradient elution chromatography. Thirty-three symptom-free patients were compared with 32 patients who exhibited uremic symptoms or complications (overhydration, the depletion syndrome, chronic or recurrent infection, isolated episodes of infection and pericarditis). The plasma concentrations of urea and creatinine were no higher in the symptomatic groups than in the controls. On the other hand, all the symptomatic groups showed higher levels of fraction 7 c in plasma than the controls. In addition, overhydration and chronic or recurrent infection were associated with high plasma levels of 7 f and 7 b respectively. Six patients with depletion syndrome, three of whom had progressive peripheral neuropathy, had significantly elevated plasma concentrations of MM including not only fraction 7 c but also fractions 7 b and 7 d. At the time of acute infections, plasma levels of 7 c were considerably higher than when the same patients were free from symptoms. Despite the association between uremic morbidity and the accumulation of MM, there is a great overlap between asymptomatic controls and "sick" uremic patients with regard to plasma levels of MM.

Adolescent↗