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Biomedical subjects

H Assmus

Publications and source records attributed to H Assmus.

At least 37 records · Page 2Linked to original sources

[Operative treatment of cubital tunnel syndrome and late ulnar paralysis by simple decompression. Report on 108 cases].

A follow-up study of 108 cases of cubital tunnel syndrome and tardy ulnar palsy, treated by simple decompression without transposition of the ulnar nerve is presented. Division and resection of the fibrous arch between the two heads of the flexor carpi ulnaris proved to be an efficacious and entirely satisfactory substitute for the more complicated and extensive procedure of volar transposition of the ulnar nerve not only for the cubital tunnel syndrome but also for tardy ulnar palsy and luxation of the ulnar nerve. Only in cases of severe cubitus valgus deformation of the elbow joint is primary transposition of the nerve recommended. Surgical decompression should be done early to get a more complete recovery in a greater number of patients.

Adolescent↗

[Sural nerve removal using a nerve stripper].

In 19 patients the sural nerve was removed for nerve grafting by a specially designed nerve stripper. This technique provides a safe and time-saving removal of the nerve in length up to 34 cm (depending on the length of the stripper used). From a single short incision at the level of the lateral malleolus the nerve is stripped proximally tearing some small branches of the distal nerve. The relatively blunt tip avoids inadvertent transection of the nerve at a lower level or dissection of the nerve at a point where branching occurs. Finally the nerve is cut by the divided cylinder at the tip of the stripper.

Humans↗

[Glycogenosis caused by amylo-1,6-glucosidase deficiency. Myopathy as a lead finding in adults].

Glycogen storage disease due to amylo-1,6-glucosidase deficiency was diagnosed in a 21-year-old patient. The enzyme defect was demonstrated by biochemical analysis of muscle tissue, the glycogen content of which was typically increased. Investigation of the patient's kindred showed that his 25-year-old sister was also affected. This report sets out to show that in adolescence and in adult life myopathy may be the leading symptom of the disease. Besides the clinical symptoms of muscle weakness and stiffness, an increase in serum creatine kinase usually is found. While an increase in the glycogen content of skeletal muscle has been known since the first description of this glycogen storage disease, it was believed that the glycogen deposits do not cause a clinically relevant disturbance of muscle function. A review of the literature and our own observations show that this assumption has to be at least partially revised. In patients with unclear myopathy who had hepatomegaly during childhood the possibility of glycogenosis due to amylo-1,6-glucosidase deficiency should be considered, especially if symptoms of hypoglycemia are reported. In the patient as well as in his sister marked kyphoscoliosis was present. Whether there is a connection between skeletal deformity and enzyme defect cannot be determined as the patients were available for further studies.

Adult↗

Chronic electrical stimulation of the thalamic unspecific activating system in a patient with coma due to midbrain and upper brain stem infarction.

Chronic intermittent bipolar electrical stimulation of the left nucleus reticulatus polaris thalami was performed in a patient in a state of subcoma due to ischaemic infarction of wide medial parts of the midbrain, mainly the tegmentum, and the right-sided mediobasal parts of the forebrain. Stimulation immediately resulted in autonomic reactions and behavioural arousal reactions during the periods of stimulation. Longterm effect consisted of a rise in the level of clinical responsiveness for a period of seven weeks. A preexistent severe pneumonia disappeared completely after one week of stimulation and returned after seven weeks. The results are discussed on the basis of the pathoanatomical findings and of the physiological functions of the damaged as well as of the stimulated areas.

Aged↗

Early myocardial disease and cramping myalgia in Becker-type muscular dystrophy: a kindred.

We present a clinical and morphological study concerning a kindred with slowly progressive X-linked muscular dystrophy (Becker type). Five males were affected; one died of heart failure at age 16. Severe and early cardiac disorder is unusual in this type of muscular dystrophy, and death at such an early age had not been reported previously. In the other patients of the kindred, cardiac abnormalities, if present at all, were nonspecific. Another unusual feature in this kindred was severe muscle pain at an early stage of the disease, a feature that cannot yet be explained.

Adolescent↗

[Somatosensory evoked cortical potentials (SSEP) in regenerating nerves following suture (author's transl)].

In 37 patients with sutured median and ulnar nerves 106 SSEP were evaluated. Stimulation of the finger nerves was performed at a rate of 4-6/sec. In the early stage of reinnervation, just when the electrical stimulus was perceived, the second positive component (P2) of the SSEP could be recorded, but the primary part of the SEP (N1/P1) was highly reduced or absent. At this time no peripheral nerve action potential or muscle action potential could be obtained. In a follow-up study the sensory regenerating process expressed in a clinical sensibility index (S1-S4+), corresponded well with latency and amplitude of the primary potential of the SSEP: N1-latency decrease and N1/P1 and especially P2/N3-amplitude increase corresponded with improving sensibility. The abnormally high P2-wave is assumed to be an expression of central adaptation and reintegration. The method seems to be of diagnostic value as a test of peripheral nerve function especially in early and late stages of reinnervation, in verification of collateral reinnervation and in objectifying sensory defects in forensic cases.

Follow-Up Studies↗

[Distal ulnar nerve compression at the wrist. "Loge de Guyon" and "deep ulnar branch" syndrome (author's transl)].

The distal non-traumatic ulnar nerve compression syndrome can be dividded into two types: -i) the proximal (paralytic) type caused by compression in the "Loge de Guyon", with involvement of both the superficial sensory and the deep branch, including the motor branch to the hypothenar muscles, and, ii) the distal, more common, purely motor type (the deep ulnar branch syndrome) with paresis of the interossei and the adductor pollicis, and less commonly of the hypothenar muscles. Whereas the proximal type has various causes, particularly pressure and occupational trauma, the distal type is almost exclusively the result of extra-neural ganglion cysts. An accurate diagnosis is made possible by electromyography and nerve conduction studies. The sensory nerve action potentials, distal motor latency to the hypothenar and adductor pollicis muscles, and the corresponding muscle action potentials after nerve stimulation are pathologically altered, according to the type of lesion. Although spontaneous recovery may occur, operation is the treatment of choice, provided that simple pressure palsy is eliminated.

Action Potentials↗

[Oerations on peripheral nerves, plexus and nerve roots, including subarachnoid block with phenol in chronic pain (author's transl)].

Peripheral surgery was performed in 112 patients. Neurolysis or resection of neurons gave rather poor results in pain after nerve injury and stump pain. Rhizotomy is considered to be more effective in those cases. Rhizotomy is also successful in radicular, especially coccygeal, pain syndromes. Subarachnoid blocks with Phenol gave similar promising results. Causalgia responds well in a high percentage of cases to sympathectomy; cases of postherpetic neuralgia phantom pain and tabetic crises generally do not respond to peripheral surgery.

Analgesia↗

[Eosinophilic granuloma of the bone in adults (author's transl)].

Eosinophilic granuloma of the bone shows a characteristic age distribution with an incidence of 75% in children. According to our observations, however, its occurrence in adults is not as rare as one should expect from the number of cases reported in the literature. The clinical and radiologic diagnosis can be established in many cases if the possibility of an eosinophilic granuloma is considered and certain criteria are taken in consideration. Solitary osteolytic changes should be biopsied early in order to avoid unnecessary and expensive examinations. The X-ray signs which can lead to the diagnosis are discussed and illustrated, and 7 cases of eosinophilic granuloma in adults are presented.

Adult↗

[Peripheral nerve compression by ganglionic cysts (author's transl)].

Extra- and intraneural ganglionic cysts rarely involved peripheral nerves. They are found in the neighbourhood of large joints. Intraneural cysts prefer the deep peroneal nerve and cause intermittent pain and severe nerve damage. The ulnar nerve is affected most often at the wrist. There are different types of distal motor and/or sensory ulnar palsy. Spontaneous recovery may take place and recurrences of intraneural cysts of the peroneal nerve occur after surgery.

Adult↗

[Ischemic contractures of muscle and nerve lesions (author's transl)].

Reporting 14 own cases symptomatology and treatment of the common ischemic syndromes of the extremities (Volkmann's contracture, thumb adduction contracture respectively contracture of the intrinsic hand muscles and anterior tibial syndrome) including the regularly concomitant nerve lesions are discussed. Edema and compression beyond the primary ischemia are essential factors in pathogenesis of nerve and muscle lesions. The electromyographic examination is helpful in diagnosis, prognosis and treatment of the severe sequelae of nerve and muscle. Since late diagnosis yields poor therapeutical results, early recognition of ischemic states and prophylaxis are most important.

Adolescent↗