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Biomedical subjects

H Atalay

Publications and source records attributed to H Atalay.

10 recordsLinked to original sources
PubMed2006

Treatment with antidepressive drugs improved quality of life in chronic hemodialysis patients.

BACKGROUND: Despite some improvements in dialysis therapies, depression still remains an important problem in chronic hemodialysis (HD) patients. In this study, we aimed to investigate the association of depression and its treatment with quality of life (QOL) in HD patients. PATIENTS AND METHODS: 97 HD patients (52 male, 45 female, mean age 55 +/- 16 years) were enrolled. All patients had been dialyzed for more than 6 months. In order to evaluate QOL of the patients, a short form of Medical Outcomes Study (SF-36) was used. Depression was assessed by using Beck Depression Inventory (BDI). Patients who had BDI score > or = 15 were diagnosed as to have depression. Patients with depression received antidepressive treatment (sertralin HCl, 50 mg/day) for an 8-week period. After 8-week antidepressive treatment, all biochemical analysis, SF-36 and BDI were performed again. RESULTS: 40 patients (20 male, 20 female, mean age 56 +/- 14 years) had depression. All parameters related to QOL were significantly decreased in patients with depression as compared to patients without depression. Severity of depression was correlated with QOL parameters. After 8 weeks of treatment, as parallel to changes in BDI, QOL parameters improved in patients with depression. CONCLUSION: Decrease in QOL, associated with depression and antidepressive treatment, improves QOL in HD patients. Hemodialysis patients should be followed-up closely for presence of depression. Treatment of depression with antidepressive drug regimen would lead to relieve the symptoms related to depression and improvement of QOL in these patients. Antidepressive treatment should be required more often than we prescribe in routine clinical practice now.

Analysis of Variance↗
PubMed2004

Simultaneous toxicity and nutrient removals in simulated DEPHANOX (anaerobic/anoxic/oxic sequentials) process treating dinitrotoluene and trichlorotoluene.

A modified DEPHANOX process including two upflow sludge blanket reactors (USB) (anaerobic-upflow sludge blanket -UASB and anoxic-upflow anoxic sludge blanket -UA(N)SB) and one completely stirred tank reactor (CSTR) system was simulated in order to detect the simultaneous removal of dinitrotoulene (DNT), trichlorotoluene (TCT), and nutrients. The phosphorus uptake and nitrification was excessively determined in aerobic CSTR reactor. Influent DNT was transformed to toluene, NH4-N and total aromatic amines (TAA) while TCT was transformed to toluene and dichlorotoluene (DCT) under anaerobic and anoxic conditions. Increasing the volumetric loading rate of DNT and TCT from 18 mg/L x day and 0.35 g/L x day to 60 mg/L x day and 1.2 g/L x day, respectively, resulted in higher COD conversion (70-80%) rates and methane productions (250-300 ml/day) in anaerobic reactor. 90% NO3-N and 87% PO4-P were achieved in anoxic and aerobic reactors at DNT and TCT loading rates as high as 40-60 mg/L x day and 0.8-1.2 g/L x day, respectively. The TAA produced under anaerobic and anoxic conditions were ultimately removed under the aerobic stage. The UASB and anoxic UASB reactor effluents were less toxic relative to the influent when analyzed by anaerobic toxicity tests and specific methanogenic activity tests, indicating that such anaerobic/anoxic aerobic sequential treatments could be able to reduce toxic organics together with nutrient removal.

Bacteria, Aerobic↗
PubMed2001

Cardiovascular safety of cocaine anaesthesia in the presence of adrenaline during septal surgery.

OBJECTIVE: The purpose of this study was to investigate the possible cardiovascular side effects of 4% cocaine solution in the presence of adrenaline during septal surgery. METHOD: Sixty adult patients undergoing elective septal surgery with local anaesthesia were included in the study. Noses were packed with 5-mL 4% cocaine (200-mg) solution on cotton pledgets, which were left in the nose for 15 minutes. Then, 10 mL of local anaesthetic (lidocaine 2% and adrenaline 1:100,000) were infiltrated in septal mucosa, and 15 minutes later, the surgical procedure was initiated. At the beginning of the operation, intervals from 12-lead surface electrocardiograms and vital signs including blood pressures and heart rate were recorded as a baseline. All measurements were repeated just before local anaesthetic infiltration, just before the beginning of the surgical procedure, and, finally, at the end of the operation. All four measurements and electrocardiographic tracings were examined. Systolic and diastolic blood pressures and QT parameters, RR intervals, and heart rates obtained from electrocardiogram were compared statistically with repeated-measures analysis of variance. RESULTS: No statistically significant difference was found among all four staged measurements. None of the patients developed tachycardia, hypertension, hypotension, or any chest pain. In electrocardiogram tracings, no sinus tachycardia depression, elevation, or bundle branch block was noted. CONCLUSION: This study shows that concomitant use of cocaine and adrenaline in the proper concentration and volume and in a carefully screened patient group was safe for the cardiovascular system.

Adult↗
PubMed1992

Erythrocyte sedimentation rates in patients with renal cell carcinoma.

The importance of erythrocyte sedimentation rate (ESR) in patients with renal cell carcinomas (RCCa) is still controversial. ESR levels increased in over half of these patients. In this study, ESR levels of 19 patients with RCCa were investigated (85.368 +/- 5.914). In 11 patients in whom carcinomas were only localized in the kidney, the ESR levels were detected as 78.182 +/- 8.686. In 8 patients who had metastasis, the ESR levels were found as 95.250 +/- 6.427. ESR levels were also estimated in 15 healthy adult persons as control group (18.133 +/- 2.180). Mean ESR values were significantly higher in the tumor group than in the control group (p less than 0.01). There was no statistical difference of the ESR levels between the patients who had local RCCa and advanced RCCa (p greater than 0.05, NS). The removal of the tumoral mass caused the ESR levels to diminish. In conclusion, the ESR levels were not a good criteria in patients with RCCa for evaluating either prognosis or metastasis.

Blood Sedimentation↗
PubMedDate not supplied

Does rigid bronchoscopy induce bacterial translocation? An experimental study in rats.

BACKGROUND: Although some reports suggest that bronchoscopy induces bacterial translocation (BT), the mechanisms of BT remain unclear. OBJECTIVE: We aimed to assess whether bronchoscopy or hypoxemia during bronchoscopy is responsible for BT. METHODS: We evaluated 24 rats divided into three subgroups: the control group (group 1, n = 8); the rigid bronchoscopy group (group 2, n = 8), and the group receiving bronchoscopy + mechanical ventilation (group 3, n = 8). Oxygen saturation (SaO(2)) was measured during the bronchoscopic procedure. Blood and tissue cultures from mesenteric lymph nodes (MLNs), liver, spleen and cecal contents were obtained 24 h following bronchoscopy. RESULTS: In group 2, SaO(2) was significantly lower than in groups 1 and 3 (p < 0.01). In group 2, BT significantly increased (6/8, 75%; p < 0.01 vs. group 1, and p < 0.05 vs. group 3). The main site of translocation was MLNs (6/8, 75%) in group 2, while BT was detected in only 1 rat in group 3 (1/8, 12.5%). CONCLUSION: Hypoxemia during rigid bronchoscopy resulted in intestinal mucosal damage in a rat model. Hypoxemia may have been the trigger for BT from the intestine following bronchoscopy.

Animals↗