PubMed Health⌕ Search

Biomedical subjects

H Ates

Publications and source records attributed to H Ates.

9 recordsLinked to original sources
PubMed2006

Evaluation of chromatographic descriptors for the prediction of gastro-intestinal absorption of drugs.

The use of chromatographic descriptors in QSAR was evaluated. Therefore, retentions were measured on an immobilized artificial membrane system, 2 micellar liquid chromatography systems and 17 orthogonal or disimilar reversed-phase liquid chromatographic systems. It was investigated whether it was possible to model gastro-intestinal absorption as a function of chromatographic retentions applying two linear and one non-linear multivariate modeling technique. In a second step it was evaluated if models built with theoretical descriptors could be improved by adding the measured retention factors to the data set of descriptive variables. It was seen that gastro-intestinal absorption could be modelled in function of chromatographic retention using the non-linear modeling technique multivariate adaptive regression splines (MARS). The best models were obtained using a combination of theoretical and chromatographic descriptors with MARS as modeling technique.

Acebutolol↗
PubMed1999

Bilateral angle closure glaucoma following general anesthesia.

Although unilateral angle closure glaucoma is quite common, simultaneous bilateral acute angle closure is very rare and is usually induced by an external cause. General anesthesia is a triggering factor for acute angle closure glaucoma. We report two cases of simultaneous bilateral angle closure glaucoma following non-ocular surgery under general anesthesia. One patient had cholecystectomy, the other craniotomy for tumor resection. In the postoperative period following general anesthesia, any patient at risk for angle closure glaucoma should be followed closely; patients with periorbital pain and visual symptoms should be examined for angle closure glaucoma attack in both eyes.

Anesthesia, General↗
PubMed1999

Non-penetrating deep sclerectomy and collagen implant surgery in glaucoma patients with advanced field loss.

PURPOSE: The aim of the study was to determine the medium term intraocular pressure (IOP) lowering effects and the potential complications of non-penetrating deep sclerectomy and collagen implant (DSCI) surgery in glaucoma patients. PATIENTS AND METHODS: 54 eyes of 52 patients with medically uncontrolled open angle glaucoma with advanced field loss underwent DSCI under topical anaesthesia. Follow-up period was 24 months. RESULTS: The mean preoperative IOP was 24.7 +/- 6.2 mmHg and decreased to 15.1 +/- 4.0 mmHg at 24 months (p = 0.0068). During the follow- up period, 36 of 54 eyes (66%) received no topical antiglaucomatous medications. In 18 eyes, monotherapy with topical beta blockers (Betaxolol HCl) was added to the regimen. At last visit, only two patients (3.8%) had IOP greater than 18 mmHg. We did not detect any additional optic disc changes, visual field or visual acuity defects postoperatively. Detailed slit-lamp examination revealed no anterior segment complications regarding the probable complications of trabeculectomy. None of the patients developed surgery related cataract. As a complication, we diagnosed one case of self-limited, shallow choroidal detachment. CONCLUSION: DSCI appears to provide considerable medium term IOP decrease with few postoperative complications without deteriorating visual acuity. Owing to our medium term results, we believe that DSCI could be a valuable alternative to trabeculectomy especially in cases of advanced medically uncontrolled open angle glaucoma.

Aged↗
PubMed1999

A simple "lasso" for intraocular foreign bodies.

Three patients had foreign bodies in their anterior chambers following penetrating ocular injuries. These foreign bodies were removed by a closed chamber technique using a simple loop. The loop was created by a 22-gauge intravenous cannula and a 7-0 polypropylene suture. Retained cilia in one patient and metallic foreign bodies in two patients were removed using this intraocular "lasso." Sutures were not placed at the incision sites at the end of the surgery. This is an inexpensive and easy to prepare technique that introduces minimal surgical trauma. In addition, two hands are not needed for loop manipulation. This technique may be an excellent alternative for removal of small intraocular foreign bodies.

Adult↗
PubMed1998

Erythrocyte deformability in high-tension and normal tension glaucoma.

The exact cause of primary open angle glaucoma is still unknown. Intraocular pressure is a major factor but it is impossible to explain the whole mechanism of glaucomatous optic nerve damage with only increased intraocular pressure. Other factors play important roles in the development of glaucoma. With this point of view, vascular factors have been implicated in the pathogenesis of glaucoma. We tried to determine the etiopathogenetic role of decreased erythrocyte deformability in normal tension glaucoma and high-tension glaucoma. The study group consisted of 16 patients with the diagnosis of normal tension glaucoma, 17 patients with the diagnosis of high-tension glaucoma, and 24 patients as controls. Independent t-tests were used to compare the three groups two by two for age, hematocrit, mean cell volume, plasma protein level, cardiovascular risk factors, and erythrocyte deformability. There was no statistically significant relationship (p>0.05) between the groups concerning the erythrocyte deformability. When we consider all of 57 patients, we found that both increasing age (>60 years) and greater mean cell volume (>84 fl) had a statistically significant relationship with decreased erythrocyte deformability (p<0.05). When we performed Pearson correlation analysis, we found that only mean cell volume and erythrocyte deformability had a statistically significant relationship (r = 0.31, p = 0.02). We conclude that decreased erythrocyte deformability is not a major factor in the ethiopathogenesis of normal tension glaucoma and high-tension glaucoma.

Adult↗
PubMedDate not supplied

Determining fluid level in a translucent eye-drop bottle: transillumination by penlight.

We describe an easy way to determine eye-drop contents in translucent bottles. Transillumination of eye-drop bottles from behind or the bottom by using a penlight clearly defines the fluid levels. The described procedure may prevent disposal of eye-drop bottles containing useful amounts of medication and prevent Ophthalmologists and Patients unexpectedly coming across an empty bottle.

Disposable Equipment↗