PubMed Health⌕ Search

Biomedical subjects

H B Dingley

Publications and source records attributed to H B Dingley.

16 recordsLinked to original sources
PubMed1984

HLA haplotype segregation study in multiple case families of pulmonary tuberculosis.

Twenty-five multiple case families of pulmonary tuberculosis were HLA typed and the data analysed by the lod score method. There was no evidence of linkage between the susceptibility gene and pulmonary TB, though there were consistently positive female scores. A number of other chromosome 6 genetic markers tested did not reveal any significant deviation in the patient group as compared to the controls, except GLO 2-1 which occurred with a significantly decreased frequency in the former.

Alleles↗
PubMed1983

Human leukocyte antigen (HLA)-linked control of susceptibility to pulmonary tuberculosis and association with HLA-DR types.

To demonstrate human leukocyte antigen (HLA)-linked control of susceptibility to pulmonary tuberculosis, 25 multiple-case families were tissue typed for class I and class II HLA specificities. Eight non-HLA genetic markers were also examined for any indication of other genetic factors that might influence the Mycobacterium tuberculosis infection. Observations on estimated HLA haplotype segregation in the sibs suggest that 84% of the affected sibs shared significantly more often than expected a common haplotype with each other than the normal unaffected sibs (P less than 0.001). Also, there was a skewed transmission of DR2 to diseased offspring from diseased parents (21 of 27) and to diseased offspring from healthy parents (15 of 17) in contrast to the transmission of DR2 from either group of parents to healthy offspring (six of 15 and 10 of 16, respectively). The segregation of non-HLA polymorphisms did not deviate significantly from the expected figures. These data provide strong evidence in favor of DR2-associated susceptibility to pulmonary tuberculosis.

Adult↗
PubMed1983

HLA-A, -B, -C and -DR antigen profile in pulmonary tuberculosis in North India.

Investigations for the HLA-A, -B, -C and -DR antigens were conducted on 124 random North Indian patients with confirmed diagnosis of pulmonary tuberculosis by the demonstration of acid fast bacilli in the sputum. 109 appropriately matched controls from the same ethnic background were also tissue typed. No significant deviation was observed in the HLA-A, -B, and -C locus antigens. With the HLA-DR typing, there was a marginal increase in DR2 and a concurrent significant decrease in DRw6 in the patient group. These deviations were, however, insignificant when correction for the P value was made. ABO blood group typing results indicate that blood group 'O' may afford protection against TB. The involvement of both DR2 and DRw6 is interesting as it is also implicated in leprosy, another mycobacterial disease. The results suggest the possibility of a common gene in the MHC for both tuberculosis and leprosy.

ABO Blood-Group System↗
PubMed1975

Factors of delayed hypersensitity in pulmonary tuberculosis.

In a study of delayed hypersensitivity in 54 patients with pulmonary tuberculosis who were on specific treatment, 33 patients could not be sensitized to dinitrochlorobenzene (DNCB) although 25 of these were tuberculin (PPD) positive. The majority of the patients also had positive skin reactions to another recall antigen, streptokinase-streptodornase. To exclude a drug effect on DNCB reactivity, 40 untreated patients were studied. Twenty-six (65 per cent) of these did not show DNCB reactivity. The cause for nonsensitization to DNCB was not clear. There was no abnormality in the number of T lymphocytes in the peripheral blood of 28 patients.

Adolescent↗
PubMed1975

Dinitrochlorobenzene contact sensitization in pulmonary tuberculosis.

Skin sensitization with DNCB was carried out in forty-five untreated, 106 "on treatment" and fifteen fully treated patients with pulmonary tuberculosis along with fifty-five controls. Mantoux test with PPD was also carried out simultaneously. All the normal controls could be sensitized to DNCB and the degree of sensitization was 4+ in majority of the subjects. In contrast, in untreated patients only eighteen could be sensitized to DNCB and the degree of sensitivity did not reach 4+ in any patient. Similarly, fifty-five patients could not be sensitized with DNCB in the group of 106 subjects who were still suffering from active disease and were on therapy and none gave a 4+ response. The difference in the proportion of subjects who could be sensitized to DNCB in these two patient groups was significantly less in comparison to controls. Among fifteen patients who were fully treated and did not have active disease thirteeen could be sensitized with DNCB, but the degree of response was again found to be less than the controls. All the patients as well as the controls gave a high proportion of Mantoux positivity. These findings indicate that there is a subtle degree of immunodeficiency in pulmonary tuberculosis which improves simultaneously with the clinical improvement.

Adolescent↗