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Biomedical subjects

H B Dumbrigue

Publications and source records attributed to H B Dumbrigue.

14 recordsLinked to original sources
PubMed2001

Control of bias in randomized controlled trials published in prosthodontic journals.

STATEMENT OF PROBLEM: Randomized controlled trials (RCTs) have become the gold standard for evaluating the effectiveness of treatment interventions. If not properly controlled, bias in the design of trial methodology can affect the validity of the study results. PURPOSE: The purpose of this investigation was to assess the methodological quality of RCTs published in 3 prosthodontic journals over a 10-year period. MATERIAL AND METHODS: Issues of The International Journal of Prosthodontics, The Journal of Prosthetic Dentistry, and The Journal of Prosthodontics published between 1988 and 1997 were searched manually to identify RCTs. Specific inclusion and exclusion criteria were established to identify articles about studies that qualified as RCTs. Two independent reviewers evaluated all qualified RCTs on the basis of how potential sources of bias in the trial methodology were controlled. Three areas-control of bias at entry, control of bias in assessment of outcome, and control of bias after entry-were evaluated with a scheme developed through the Cochrane Collaboration. A score of 1 or 0 was assigned for each of the 3 potential sources of bias, with the maximum quality score for an RCT being 3 (good bias control) and the minimum 0 (poor control). Frequencies were calculated for each dimension of trial methodology and overall quality scores of the RCTs. RESULTS: Sixty-two RCTs were identified from 3631 articles screened. The method of randomization was explicit in only 47% of the RCTs. Forty percent of RCTs incorporated blinding in the assessment of outcome, and 76% accounted for all subjects at the end of the study. Overall quality scores revealed that only 16% of RCTs attempted to control bias in all 3 areas examined. Forty percent were deficient in 1 area, 34% were deficient in 2 areas, and 10% were deficient in all areas examined. CONCLUSION: The quality of RCTs published in prosthodontic journals may be improved by minimizing potential sources of bias and adequately reporting trial methodology.

Dental Research↗
PubMed2000

Salivary epidermal growth factor levels decrease in patients receiving radiation therapy to the head and neck.

OBJECTIVE: The objective of this study was to assess changes in salivary epidermal growth factor (EGF) in patients receiving radiation therapy to the head and neck and to determine whether salivary EGF levels correlate with the severity of radiation-induced oral mucositis. STUDY DESIGN: Thirteen patients and 18 control subjects were enrolled in the study. Saliva was collected before, during (weekly), and after radiation therapy. Salivary total protein (TP) and EGF concentrations were measured and correlated with the severity of oral mucositis. The variability in normalized EGF (ngEGF/mgTP) values and mucositis scores were analyzed with analysis of covariance, and the adjusted correlation coefficient was calculated. RESULTS: EGF levels decreased (P =.004), whereas TP levels increased over time (P =.039). A strong correlation was seen with decreasing normalized EGF values and more severe mucositis (P =. 0001). CONCLUSION: A strong negative correlation between normalized EGF and mucositis severity suggests a possible role for EGF in the progression of radiation-induced mucosal breakdown.

Adult↗
PubMed2000

Prefabricated acrylic resin bars for splinting implant transfer copings.

Splinting of implant transfer copings with acrylic resin during impression procedures is performed to accurately transfer the spatial relationships of implants to the master cast. However, distortion may occur during the splinting procedure because of resin polymerization shrinkage. This article describes a simple technique for minimizing this effect by fabrication of resin bars.

Acrylic Resins↗
PubMed2000

Assessment of MEDLINE search strategies for randomized controlled trials in prosthodontics.

PURPOSE: The purpose of this study was to evaluate the sensitivity, specificity, and precision of MEDLINE search strategies for detecting randomized controlled trials (RCTs) in prosthodontics. MATERIALS AND METHODS: A list of RCTs was obtained by hand-searching the International Journal of Prosthodontics, Journal of Prosthetic Dentistry, and Journal of Prosthodontics published between 1988 and 1997. RCTs identified served as the "gold standard" with which different MEDLINE search strategies were compared. Subject headings, keywords, MEDLINE checktags, publication types, and combinations thereof were used, and their results were compared with the "gold standard". RESULTS: Sensitivity ranged from 9% to 67%, specificity was at least 96% for all searches, and precision ranged from 22% to 59%. The most productive searches were by publication type clinical trial and publication type randomized controlled trial. Combining search terms did not improve sensitivity for detecting RCTs published in prosthodontic journals (p > .10). CONCLUSION: These findings support the need for more detailed reporting of trial methodologies to facilitate accurate indexing of prosthodontic articles in MEDLINE.

Humans↗
PubMed1999

Developing a register for randomized controlled trials in prosthodontics: results of a search from prosthodontic journals published in the United States.

STATEMENT OF PROBLEM: Treatment decisions are often made despite absence of evidence from well-conducted clinical trials. Conclusions about treatment efficacy derived from nonexperimental approaches often overestimate treatment effect. Randomized controlled trials (RCTs) provide the most reliable basis for evaluating effectiveness of treatment interventions. PURPOSE: This study attempted to identify and catalog RCTs in prosthodontic journals published in the United States as an initial step in creating a register of clinical trials that would be a resource in setting up systemic overviews of prosthodontic literature. METHODS: The International Journal of Prosthodontics, The Journal of Prosthetic Dentistry, and The Journal of Prosthodontics published between 1988 and 1997 were searched manually to identify clinical trials. Clinical trials had to meet the following criteria for inclusion in the register: the trial must involve human subjects, must include at least 2 treatment groups, and treatment group allocation must be randomized. RESULTS: A total of 3,631 articles in 196 journal issues were screened. Sixty-two articles (1.7%) met the minimum criteria for inclusion in the RCT register. CONCLUSION: Given the lack of randomized controlled trials in prosthodontic journals, a concerted effort by the organized prosthodontic community should be made to screen national and international journals and contribute to the development of a register of randomized controlled trials relevant to prosthodontics.

Dental Research↗
PubMed1998

Selective-pressure single impression procedure for tooth-mucosa-supported removable partial dentures.

This article describes a method of making impressions for tooth-mucosa-supported removable partial dentures using a single impression procedure. Through the use of border-molded custom trays, selectively relieved, and application of pressure on residual ridge areas, the objectives of maximum tissue coverage and selective tissue placement of primary stress-bearing areas are fulfilled. With a single impression procedure, treatment time is reduced and laboratory errors commonly encountered with the altered cast impression technique can be minimized or eliminated.

Dental Impression Materials↗
PubMed1998

Fabrication procedure for cranial prostheses.

A procedure for duplication of cranial bone flaps used in cranioplasty is described. This procedure overcomes the difficulties inherent in direct duplication of irregular-shaped bone flaps through primary replication of the flap in wax. The wax pattern is used to fabricate the definitive prosthesis.

Acrylic Resins↗
PubMed1997

Anterior margin adaptation for implant-retained auricular prostheses.

Adaptation of the anterior margin of implant-retained auricular prostheses may be compromised during mandibular movement. Loss of contact between prostheses and underlying skin in an esthetic area is of great concern. This article describes an impression procedure that addresses the problem of anterior margin adaptation.

Acrylic Resins↗
PubMed1997

A comparative study of anesthetic techniques for mandibular dental extraction.

PURPOSE: To compare the effectiveness of the intraligamentary technique of anesthetic administration (ILA) with the inferior alveolar nerve block (IANB) in extraction of mandibular teeth. MATERIALS AND METHODS: ILA and IANB injections using Citanest with Octapressin were administered on 16 patients requiring bilateral mandibular dental extractions. Discomfort during needle placement, profoundness of anesthesia obtained, and patient preference were evaluated for both techniques. RESULTS: A total of 45 teeth were extracted. Ten patients (62.5%) reported discomfort during needle placement with ILA injection compared to three patients (18.75%) with IANB (P = 0.031). Fifty percent (12/24) of teeth extracted with ILA injection were removed without discomfort to the patient compared to 85.7% (18/21) using IANB (P = 0.027). No difference in patient preference between the two techniques was noted.

Adult↗
PubMed1996

Impression technique for nonosseous free-tissue transfer reconstruction after cranioorbitomaxillary resection: A clinical report.

The use of vascularized free-tissue transfers has given the head and neck surgeon the ability to offer enhanced oncologic therapy with less risk of exposing vital structures to the aerodigestive tract. Resulting free-flap tissue consistencies and contours inhibit the successful use of routine impression techniques. The technique described in this clinical report uses a previously reported procedure to obtain an accurate impression of residual palatal and free-flap structures. The significance of this technique is that it improves the tissue reproduction of surgically closed palatal defects.

Carcinoma, Squamous Cell↗