PubMed Health⌕ Search

Biomedical subjects

H B Hupf

Publications and source records attributed to H B Hupf.

10 recordsLinked to original sources
PubMed1981

Production of Curie quantities of high purity I-123 with 15 MeV protons.

Using the technology described for electrodeposition of elemental tellurium, it is possible to bombard a target with 2 kW of proton beam power without significant loss of radio iodine. If Te-123 enriched to 96% is used as target material, the I-123 yield would be about 1 Curie with a 0.23% I-124 impurity for a 2-h bomardment with 130 muA of 15 MeV protons. The same I-124 impurity level can be maintained with a lower enrichment of Te-123 by reducing the proton energy to 11.5 meV, but with a consequent reduction in I-123 yield.

Iodine Radioisotopes↗
PubMed1978

Rapid radioiodination of rose bengal at room temperature.

Published methods for radioiodination of rose bengal require reaction times of 1 hr or more at temperature from 50 to 120 degrees C. Through the use of an acidified ethanol solvent and potassium iodate oxidant, purified rose bengal is radioiodinated at room temperature within 15 min with chemical yields ranging between 93 and 97%. Radiochemical impurities are sufficiently minimized to permit preparation in a single 10-ml serum vial, requiring no additional purification steps. The method reported here is readily adaptable to cold-kit preparation.

Iodine Radioisotopes↗
PubMed1975

Iodine-123-Rose bengal: An improved hepatobiliary imaging agent.

A practical method for preparing )23-I-rose bengal that allows for its rapid and efficient incorporation into the molecule is reported. Administration of 123-I-rose bengal to normal healthy patients showing the normal uptake and excretory pattern visualized with this radio pharmaceutical is also presented. The overall reduction in imaging time and radiation exposure together with the improved images possible should greatly improve our diagnostic capabilities in evaluating the jaundiced patient.

Humans↗