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Biomedical subjects

H B Svindland

Publications and source records attributed to H B Svindland.

13 recordsLinked to original sources
PubMed1985

Isolation of an acidic polysaccharide antigen from Propionibacterium acnes.

An acidic polysaccharide antigen is released from Propionibacterium acnes I and II during growth. The molecular weight of the antigen was heterogeneous and when fractionated on a Sepharose CL-6B column, the antigen was detected at Kav values of between 0.1 and 1.0. The pI of the antigen was below 3.5. Rabbit antiserum raised against purified acidic-polysaccharide agglutinated P. acnes showing that the polysaccharide was a surface antigen. Human antibodies towards whole P. acnes-II organisms were quantitated by an agglutination technique, and antibodies towards purified acidic polysaccharide were quantitated by single radial immunodiffusion. A high prevalence of antibodies against whole bacteria and the acidic polysaccharide was found in sera from healthy individuals. The antibody titre in sera from acne patients was significantly higher than that in sera from blood donors.

Acne Vulgaris↗
PubMed1982

Quinolone derivative, flumequine, as short-term treatment for gonorrhoea.

The antigonococcal activity of the quinolone derivative flumequine was evaluated. Of 246 strains examined, 240 (97.5%) strains showed minimum inhibitory concentrations (MICs) of flumequine of less than or equal to 0.4 microgram/ml, including three beta-lactamase-producing strains. The six remaining strains showed MICs from 3.2 to 9.6 micrograms/ml. By disc diffusion tests using 3-micrograms discs of flumequine the zones of growth inhibition correlated well with the MICs of flumequine. The effect of treatment with flumequine was compared in 239 patients with uncomplicated gonorrhoea. A single dose regimen of 1200 mg flumequine orally, a two-dose regimen of 1200 and 800 mg, and a three-dose regimen of 1200, 800, and 800 mg (six hours apart) were given. With a single dose of flumequine the failure rate was 26%. The two-dose and three-dose regimens were equally effective with an overall cure rate of 95.4%. In patients harbouring beta-lactamase-producing gonococci the infection was cured. The failures (10 men) included all of the six patients infected with flumequine-resistant gonococci. Side effects were noted by 14.6% of the patients and were mostly described as dizziness.

Adolescent↗
PubMed1981

Subacute parathion poisoning with erysipeloid-like lesion.

A case of subacute parathion poisoning with an erysipeloid-like eruption of the left index finger is reported. Laboratory investigations showed no growth of pathogenic bacteria and cholinesterase activity in the blood showed a rise 10 days after the poisoning. Further blood investigations 6 weeks later showed subnormal levels of cholinesterase activity indicating chronic parathion poisoning.

Adult↗
PubMed1975

A case of pigmentary hair naevus (Becker).

A healthy 14-year-old Norwegian male developed a typical Becker's naevus on the left shoulder and upper scapular region, about six months after an intracutaneous BCG-vaccination in the homolateral junction of the shoulder and upper arm. The evolution of the lesion had been modified by exposure to sunlight during the following six years, with partial fading of the hyperpigmentation. Biopsies taken from the centre and from the edge of the lesion at the age of 19 years showed the usual histological picture seen in cases of Becker's naevus, but focal areas within the periphery showed a chronic granulomatous infiltrate of lupoid pattern in the dermis, mainly follicular and perifollicular in distribution. Acid-fast bacilli were not demonstrable in the sections, and in culture no tubercle bacilli were isolated from a central and histologically non-specific site. The implications of the histological findings are discussed, stressing the possibility that Becker's naevus may be a form of cutaneous tuberculosis caused by BCG or other mycobacteria of low virulence, precipitated by ultraviolet light and possibly modified by immunological factors.

Adolescent↗