Contact dermatitis from clotrimazole.
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Biomedical subjects
Publications and source records attributed to H Baes.
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A case of allergic contact dermatitis from miconazole is reported. Patch testing with a series of azole antimycotics was positive only to miconazole, isoconazole, tioconazole and oxiconazole. Those reacting are all beta-substituted 1-phenethyl imidazoles with an ortho-chlorine substitution on the aromatic ring. For this hitherto unreported pattern of cross-sensitivity, the designation of "ortho-chloro cross-sensitivity" is proposed.
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A 53-year-old man, a pigeon fancier, with long-standing asthma, treated for years with systemic corticosteroids, developed a fast-growing mass on his right wrist. The diagnosis of cryptococcosis was established by histology and culture of tissue which yielded Cryptococcus neoformans. Oral treatment with ketoconazole for 3 months resulted in a complete cure with residual hyperpigmentation and minute scars. During a 10-month follow-up, the patient was free of recurrences.
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