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H Baird

Publications and source records attributed to H Baird.

11 recordsLinked to original sources
PubMed1990

Definition of glomerular antigens by monoclonal antibodies produced against a human glomerular membrane fraction.

Experimental animal models of glomerulonephritis (GN) produced by direct antibody binding to non-basement membrane glomerular capillary wall antigens do not to date have human parallels. To examine the potential for this form of humoral glomerular injury in man, we sought to define discrete human non-GBM glomerular antigenic targets using hybridoma technology. Mice were immunised intraperitoneally with 20-100 micrograms of a human glomerular membrane fraction (HGMF). Six fusions have yielded 12 stable reagents defined by positive glomerular indirect immunofluorescence (IF) and microELISA using HGMF as the screening antigen. Subclass analysis of ascitic McAbs indicated several IgG1, one IgG2b, and three IgM reagents. Distinctive IF patterns of reactivity with epithelial, endothelial or mesangial structures have been observed, with or without peritubular capillary, tubular basement membrane and vessel wall reactivity. Seven normal non-renal human organs and the kidneys of rat, rabbit and sheep have shown patterns characteristic of each individual McAb, restricted to human or with species cross reactivity. To partially characterise McAb-reactive antigens, detergent-solubilised renal cortex and collagenase-solubilised GBM (CS-GBM) extracts have been probed by immunoblot. A unique McAb 7-5Q, reactive with glomerular and tubular epithelial structures, binds major bands of approximately 107 KD and 93 KD in detergent solubilised cortex and a single band of similar size by immunoprecipitation (110 KD). 5-3A (a human-restricted linear-reacting McAb) binds bands of 20-200 KD (major band 58 KD) in CS-GBM. In conclusion, distinct species-restricted and more broadly disposed glomerular epitopes are definable in man by McAbs and are potential targets for humoral injury. Purification of these antigens will allow assay for circulating putative nephritogenic auto-antibody and potentially, McAbs may be useful in screening urine for evidence of occult structural renal disease.

Animals↗
PubMed1985

Immediate coronary care in general practice--a three-year review.

The general practitioners in a rural practice in a three-year period were called to 101 patients (25% female) who suffered a myocardial infarction. The average response time was 15 minutes. Seventeen patients collapsed and died and the 84 who survived the initial period were given immediate coronary care and either cared for at home, admitted by cardiac ambulance to a coronary care unit, or admitted to a general medical ward with monitor facilities. The four-week mortality rates were 21.0%, 21.5% and 57.7% respectively. Thirty-six patients required treatment for arrhythmias in the initial care period, of whom nine required defibrillation. This survey supports the view that patients over the age of 60 years with uncomplicated myocardial infarction may be cared for successfully at home.

Adult↗
PubMed1982

Normative values for brain stem auditory evoked potentials obtained by digital filtering and automatic peak detection.

A BAEP test which uses constant, high level click stimulation was developed for preliminary screening of patients with known or suspected problems in auditory information processing. Digital filtering and automatic peak detection were employed to aid in the analysis of BAEP component latencies. The results of 148 BAEP tests allowed us to select a set of normative measures: absolute peak latency, interpeak latency and left-right peak latency difference. The set of threshold values was developed for selected BAEP measures, in order to evaluate test results.

Adolescent↗
PubMed1980

Developmental equations reflect brain dysfunctions.

Developmental equations, which predict 32 parameters of the electroencephalogram recorded from the healthy human as a function of age, were tested in diverse groups of children. Few significant deviations were found in normal children, even in a culture different from the one on which the equations were based. A high incidence of significant deviations was found in children with learning disabilities and those at risk for various neurological disorders.

Adolescent↗