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Biomedical subjects

H Bardach

Publications and source records attributed to H Bardach.

At least 19 recordsLinked to original sources
PubMed1989

[Apocrine chromhidrosis].

Apocrine chromhidrosis is an extremely rare and impressive skin disorder. Primarily after emotional stress patients complain of coloured sweat secretion (black, green, blue or yellow). The deposition of lipofuscin in the apocrine glands may be the cause of this disease, the different colours of sweat being due to various oxidation stages of lipofuscin. We report two patients, one with blue and one with green axillae; the clinical features, histopathology, differential diagnosis, and pathogenesis of apocrine chromhidrosis are discussed.

Aged↗
PubMed1983

[Single-dose penicillin therapy of acute gonorrhea].

A new penicillin preparation (sodium-penicillin G3.5 mill. I.U., clemizolpenicillin G 1.0 mill. I.U.) has been tested with regard to the treatment of uncomplicated gonococcal infections during a multicenter trial in Vienna. 101 out of 102 patients could be sufficiently cured by one single injection of the preparation.

Acute Disease↗
PubMed1982

[ANF-negative subacute cutaneous lupus erythematosus with anti-Ro antibodies. A new subset of lupus with characteristic skin manifestations].

Recently a new subset of lupus erythematosus with distinct cutaneous lesions has been defined as subacute cutaneous lupus erythematosus. The salient clinical features are transient nonscarring widespread erythematosquamous or annular eruptions on the trunk and arms, cytopenia, musculo-skeletal symptoms and sometimes mild renal and cerebrovascular disease. Although more than one half of the patients have positive antinuclear factor tests, in a smaller proportion only antibodies against the predominantly cytoplasmic antigens Ro and sometimes La can be demonstrated. Due to the negative routine serologic findings the typical cutaneous lesions assume additional importance, because they frequently allow a clinical diagnosis even in the absence of more sophisticated immunologic procedures.

Antibodies, Antinuclear↗
PubMed1982

[Genodermatosis in a pair of brothers: Dowling-Degos, Grover, Darier, Hailey-Hailey or Galli-Galli disease?].

A peculiar polymorphous eruption in two brothers is reported. Histological examination of hyperpigmented macular lesions on the face and neck revealed all diagnostic features of the Dowling-Degos disease. With the electron microscope, singly dispersed melanosomes could be demonstrated in the basal keratinocytes. In biopsies from the erythematosquamous pruriginous lesions in the flexural areas, on the trunk and extremities, acantholysis, formation of lacunae, and some corps ronds were the predominant histological findings. Reduction of desmosomes, separation of desmosomes and tonofilaments, as well as thickened collagen-like tonofilaments could be shown. Not infrequently within a single lesion, all the features compatible with Dowling-Degos, Hailey-Hailey, Darier, and Grover disease were present. Pending further investigations and observation of patients with similar findings we propose with the consent of the patients, the term "Galli-Galli" disease as preliminary designation of this genodermatosis.

Acantholysis↗
PubMed1981

[Oculodermal melanocytosis (nevus of ota) and blue nevus (author's transl)].

Report is made of a patient having concurrently an Ota nevus and a blue nevus. The dermal melanocytes showed a marked formation of large intracytoplasmatic vacuoles. Reference to the important role of an "extracellular sheath" is made. The nearly identical ultrastructural characteristics of dermal melanocytes in various dermal melanocyte disorders seems to imply a common pathological origin in their development.

Adult↗
PubMed1981

[Penicillamine-induced elastosis perforans serpiginosa and pulmonary cyst in Wilson's disease (author's transl)].

A large air cyst was removed from the right lung of a 29-year-old female patient with Wilson's disease and penicillamine-induced perforating elastosis, the cyst first appearing after 9 years of treatment with penicillamine. Since, on the one hand, the microscopic and ultrastructural changes in the elastic tissue of the lungs were identical to those observed in the skin, both in areas of clinically-demonstrable elastosis perforans serpiginosa and clinically unaffected skin and, on the other hand, no other pulmonary disease was demonstrable to account for the development of the cystic lesion, it is concluded that penicillamine is the causative factor by means of extensive alteration of the elastic tissue. The morphological changes in the elastic fibres are so characteristic that it is easy to distinguish penicillamine-induced elastosis perforans serpiginosa from the idiopathic variant.

Adult↗
PubMed1981

[Subcutaneous Dirofilaria (Nochtiella) repens infection in man--report of the first case in Austria and review of the literature (author's transl)].

A 39-year-old female patient developed migratory skin nodules 4 months after a vacation in Greece. The patient observed a total of 17 nodules moving over the trunk to the left thigh, where a subcutaneous lesion was excised, yielding a parasite measuring 0.5 mm X 7 cm. It was classified as Dirofilaria (Nochtiella) repens. Since this is the first case observed in Austria, an exact description of subcutaneous dirofilariasis, its geographical distribution and a review of the literature is presented.

Adult↗
PubMed1981

[Furunculoid myiasis due to Cordylobia anthropophaga in a traveler returning from Africa and review of the literature].

A 45-year old tourist returning from Dakar, Senegal had furunculoid cutaneous myiasis caused by larvae of Cordylobia anthropophaga. The diagnosis was made on the return to Vienna by identification of the larvae found in the skin lesions. Since the cutaneous lesions may be easily confused with ordinary types of furunculosis, the diagnosis of cordylobiasis should be excluded in all travelers returning from endemic areas (Africa south to the Sahara), because this disease may be much more common than hitherto suspected. In addition to the differential diagnosis a review of the literature on similar case reports in recent years is presented.

Africa↗
PubMed1981

[Acariasis due to dermanyssus gallinae (gamosoidosis) in Vienna (author's transl)].

Four cases of gamasoidosis (avian mite dermatitis) caused by Dermanyssus gallinae (De Geer 1778) were observed in a factory for optical instruments in Vienna. After removal of an infected pigeon nest outside one of the windows in a recess of the wall in front of a fan, no further skin lesions appeared. The darkening of the room during work hours could explain the activity of the mites during day time. Although gamasoidosis is mainly seen in rural areas, it is not infrequently encountered in urban settings and should always enter the differential diagnosis in the presence of pruriginous skin lesions not meeting all of the diagnostic criteria of scabies.

Austria↗
PubMed1981

[Angiotensin-converting enzyme (ACE). Increased serum activities in patients with dermatological diseases (author's transl)].

Serum activities of ACE were investigated in 40 patients with dermatological disease and in nine patients with sarcoidosis. The method of Cushman and Cheung, modified according to Lieberman, was used. Both sarcoidosis patients and patients with dermatological diseases showed marked elevations of ACE-activity. The increase in ACE-activity might result from inflammation and immunological events.

Humans↗
PubMed1981

[8-Methoxypsoralen (8-MOP)-a new galenic form and its relation to 8-MOP serum levels (author's transl)].

A bioequivalence study was performed with two different 8-MOP preparations. Thirty-eight patients participated in the investigation. We compared a product already marketed containing a micronized powder in hard gelatine capsules with a new product in soft gelatine capsules containing the 8-MOP in a solution. With the new galenic preparation the serum level obtained was 3.2 (P less than or equal to 0.01) times higher than with the old product. Thus, the improved resorption out of the solution was mainly responsible for these results.

Dosage Forms↗
PubMed1981

Perforating lichen nitidus.

A skin biopsy from an 8-year-old boy with generalized lichen nitidus revealed a transepidermal perforating lesion never observed before in this disorder. A disturbance in dermo-epidermal interaction with alterations of epidermal cell kinetics could explain this finding in a disease which, curiously, shows many histologic features conducive to transepidermal perforation. A clear distinction should be made between primary and secondary perforating dermatoses, since perforation per se is a non-specific cutaneous reaction pattern occurring in the course of many unrelated disorders.

Child↗
PubMed1981

Acute ocular hypotony. A rare complication of temporal arteritis.

Acute ocular hypotony is a serious, but rare complication of temporal arteritis. It occurs equally often in men and women, and appears mostly in patients older than 70 years. This complication may occur in one or in both eyes. In the literature 7 cases of temporal arteritis accompanied by ocular hypotony have been reported. Hypotony probably results from a restricted production of aqueous humor caused by involvement of the arteries supplying the ciliary body. A high-dose corticoid therapy may normalize completely the intraocular pressure, and a timely treatment may preserve a satisfactory vision, since an insufficient perfusion of the optic disc does not necessarily occur. Scalp necrosis and diplopia may appear at the same time, and are a sign of multiple involvement of the arterial vessels.

Aged↗
PubMed1981

[Localized poikiloderma vascularis atrophicans as an early manifestation of Hodgkin's disease of the nodular-sclerosing type].

A 33-year-old female patient is presented with a nine-year history of poikilodermatous, eventually ulcerative skin lesions on the right neck and shoulder. A work-up revealed Hodgkin's disease of the nodular sclerosing type with specific cutaneous infiltrations. Initial combination polychemotherapy followed by supradiaphramatic irradiation has resulted in complete clinical remission of the disease since 15 months.

Adult↗
PubMed1981

The "lumpy-bumpy" elastic fiber. A marker for long-term administration of penicillamine.

A 29-year-old woman with Wilson's disease developed dermolytic skin lesions 2 years after initiation of treatment with penicillamine. Eight years later, still on penicillamine therapy, striae appeared over both of her breasts. Biopsy of involved skin during the 10th year of treatment with penicillamine revealed characteristic lumpy-bumpy alterations of dermal elastic fibers which were not present in the first skin biopsy 8 years previously. Biopsy of a stria showed changes similar to those in the dermolytic skin lesions. Lumpy-bumpy elastic fibers are pathognomonic for penicillamine-induced elastosis. They are easily recognizable with examination by conventional microscopy. Their appearance may serve as a warning of potentially serious, widespread elastic tissue involvement. These abnormal elastic fibers are not only found in the skin, but also in the lungs.

Adult↗