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Biomedical subjects

H Bercher

Publications and source records attributed to H Bercher.

8 recordsLinked to original sources
PubMed1979

[Acute and subchronic experiments on the effects of microcrystalline cellulose on various pharmacological and biochemical parameters in mongrel rabbits].

The subchronic intravenous application of microcrystalline cellulose (MCC), in a dose of 5 mg/kg twice weekly for 10 weeks, resulted in servere crystal embolism in the lungs of the animals. The clinical parameters were either unchanged (erythrocyte and leucocyte counts, differential blood picture, osmotic resistance of the erythrocytes, total serum bilirubin, serum protein and serum protein fractions) or slightly pathological (hemoglobin content, hematocrit, GOT and GPT). The results from tests of the liver function (by means of bromosulphthaleine clearance) and of the renal function as well as the ophthalmologic examination were not indicative of damaged parenchyma or disturbed microcirculation. Intra-arterial infusions of MCC affected the peripheral muscular blood supply, blood pressure and heart rate.

Animals↗
PubMed1978

[Correlations between chemical structure and cardiac effectivity of a group of beta-receptor blockaders].

13 compounds from the families of halogenated phenylethanolamines and phenoxypropanol-amines were tested for their antagonistic effect against an isoproterenol-induced increase in heart rate and lowering of blood pressure, and the AD50 values were determined. All the substances had beta-adrenolytical effects. 2.4-Difluoroisoproterenol and 1-(2.4-dichlorophenoxy)-3-t-butylaminopropanol-(2) showed a higher affinity to the beta1-receptors of the heart than to the beta2-receptors of the vessels. Correlations existing between chemical structure and action on the adrenergic beta-receptors are described.

Adrenergic beta-Antagonists↗
PubMed1976

[Structure-activity relationships of halogenated phenylethanolamine and phenoxypropanolamine].

12 compounds from the series of halogenated phenylethanolamines and phenoxypropanolamines were tested at the isolated rabbit jejunum, and the pD2-and pA2-values were determined. All the substances act beta-adrenolytically. Except for 3,4-dichloronoradrenaline, which stimulates the alpha-receptors, all the compounds still have pronounced beta-mimetic effects. The 2,5-dihalogenated phenylethanolamines and phenoxypropanolamines block the beta-receptors at lower concentrations than 2,4-dihalogen derivatives. The weakest beta-adrenolytic effects at the intestine were found with compounds halogenated at the 3,4-position.

Adrenergic beta-Antagonists↗
PubMed1975

[The effect of fluoridated phenylethanolamines on hyperglycemia induced by catecholamines in the rat].

10 compounds from the 2.4- and 3.4-difluorinated phenylethanol-amines series were tested for their antagonistic action against a hyperglycemia induced by catecholamines in rats, and the ED50 and AD50 values were determined. All the substances acted beta-adrenolytically, with the glycogenolysis enhanced by isoproterenol being blocked more potently by 3.4-difluorophenylethanolamines than by the corresponding 2.4-difluoroderivatives. An exception in the series is 2.4-difluoro-n-butylnoradrenalin, which acts 10fold more beta-adrenolytically than the 3.4-difluoroderivative, and has 3 times the effect of the comparative substance dichloroisoproterenol.

Animals↗