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H Bitter-Suermann

Publications and source records attributed to H Bitter-Suermann.

68 records · Page 4Linked to original sources
PubMed1975

Morphologic features of spleen allografts in rats. Graft rejection, acceptance, or lethal graft-versus-host disease in the same donor-recipient pairing.

The structural changes in serial biopsies of spleen allografts in inbred histoincompatible rats are described. Three experimental procedures in the same donor-recipient pairing (PVG to AGUS) were employed and resulted in spleen graft rejection (Group I, no pretreatment), spleen graft acceptance (Group II, hosts pretreated with donor cells), and lethal GVH disease (Group III, donors pretreated with host cells). Striking features in the three groups were the variation of involvement of the periarterial lymphatic sheaths (PALS) shortly after grafting, and a substantial increase in hemopoiesis, particularly erythropoiesis, in the red pulp. The very "quiet" cellular reaction in the PALS of the host spleens in Group II corresponded with permanent graft acceptance. In Group III the previously sensitized allografts behaved rather like Group I host spleens and, by causing fatal GVH disease, demonstrated their immunologic superiority.

Animals↗
PubMed1972

Liver preservation by single passage hypothermic "squirt" perfusion.

A single passage, hypothermic, intermittent squirt perfusion of the pig's liver is described which has allowed preservation of porcine livers for up to 17 hours. After preservation, orthotopically allografted livers can maintain recipient animals in good health. If this technique can be applied to clinical liver transplantation it should be possible to move livers from one hospital to another in the same way that kidneys are transported. This should increase the availability of donor livers for transplantation and avoid the serious disadvantages of moving the sick recipient just before the operation to the hospital where the donor has died.

Animals↗