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Biomedical subjects

H Blanke

Publications and source records attributed to H Blanke.

78 records · Page 5Linked to original sources
PubMed1978

Haemodynamic effects of molsidomin.

Hemodynamic changes for 30 min after intravenous administration of molsidomin 4 mg were studied in 10 patients. Pulmonary artery pressure, pulmonary wedge pressure, right atrial pressure and aortic pressure decreased significantly after 15 min, and after 30 min they were still below the control level. Heart rate increased significantly (by 15%) 15 min after injection, and after 30 min it was still 8% above the control value. Cardiac index decreased significantly from 3.37 +/- 0.12 to 2.95 +/- 0.15 1/min/m2. Peripheral and pulmonary resistance showed no significant change. Both stroke work index and minute work decreased significantly 15 min after administration of molsidomin and after 30 min both were still below the control level. The results suggest that molsidomin decreases preload without influencing afterload. By decreasing preload, molsidomin improves the oxygen supply/demand ratio of the myocardium.

Adult↗
PubMed1977

[Haemofiltration in the treatment of acute left heart failure in anuric patients (author's transl)].

Eight patients with acute left heart failure refractory to diuretics were treated by haemofiltration. Used conventionally the filtration membranes need a high pressure gradient. But the hollow-fibre kidney use in the last three patients required merely normal arterial venous pressure gradients. During an average heaemofiltration period of four hours 1000-2300 ml of plasma water were obtained. Pulmonary congestion improved in all patients; in five the arterial pressure returned to normal. Spontaneous diuresis was resumed in three. The clinical course was not influenced by haemofiltration in three instances. The advantages of haemofiltration are: reliable control of volume withdrawal, immediate effectiveness, technical simplicity, and absence of side effects.

Aged↗