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Biomedical subjects

H Brzezińska

Publications and source records attributed to H Brzezińska.

At least 19 recordsLinked to original sources
PubMed1989

[Mast cells of the pharyngeal tonsils].

The adenoidal mast cells were obtained from the adenoids by enzymatic dispersion of the tissue by enzyme collagenase. Mast cells constituted 1-2% of total cell population and were morphologically intact, as judged by light microscopy. They could be sensitized passively in vitro with homologous reaginic serum and released histamine after challenge with specific antigen. The adenoidal mast cells released histamine after challenge with anti-IgE. These cells were unresponsive to the action of compound 48/80 and had low sensitivity to the action of polymyxin B, concanavalin A and ionophore A23187. Our studies have shown that mast cells obtained from adenoids by enzymatic dispersion can be used for experiments in vitro.

Adenoids↗
PubMed1984

Concentrations of cloxacillin and erythromycin in the tonsils of children after administration of therapeutic doses.

The treatment of infections in the ring of Waldeyer in children is an ever present problem. Most infections are caused by group A streptococci, and various antibiotics are routinely used for their treatment. In many cases, however, this treatment is ineffective as demonstrated by prolonged disease duration and recurrences. This may be due to the resistance of the pathogens to the used antibiotic, too low dose, or inadequate penetration of the drug into the focus of infection. To explain this problem the reported investigation was undertaken carrying out bacteriological investigations of the removed tonsils and determining antibiotic concentrations in tonsil homogenates and in the serum after cloxacillin and erythromycin treatment of 45 children aged 4-14 years subjected to tonsillectomy or adenotomy . It was found that the most frequent aetiological factors in angina and adenoiditis were group A streptococci. Cloxacillin and erythromycin are the antibiotics penetrating well into the lymphoid tissue and reaching high concentrations in the focus of infection but the courses of treatment should not be shorter than 10 days.

Adolescent↗
PubMed1983

Life endangering tumors in the ENT region in children.

Forty children with life-endangering tumors localized in the ENT region were treated during the last 10 years at two clinics in Poland: the Oncological Clinic in Warsaw and the Otolaryngological Children's Clinic in Lódź. In this group there were 29 malignant tumors at different pathology, and 11 non-malignant tumors that became life-endangering because of their size and localization. These children were treated, dependent on the nature of the tumor, with surgery, chemotherapy and X-ray therapy.

Adolescent↗