Biomedical subjects

H Buhl

Publications and source records attributed to H Buhl.

18 recordsLinked to original sources

PubMed1988

[Effect of physical training on the aerobic-anaerobic transition in chronic liver diseases].

7 males, aged 30 to 60 years, with bioptically ascertained chronic liver diseases underwent a four-week preservance training programme on the bicycle ergometer in the aerobic-anaerobic transitional area (performance at 2-4 mmol 1(-1) lactate). The training caused a significant amelioration of the aerobic functional capacity of the test persons. The hypothesis of a liver-protective effect of the perserverance training was confirmed. The inclusion of a dosed physical training in the therapy and rehabilitation programme, respectively, of patients with chronic liver diseases can be recommended, particularly, since there is no causal medicamentous therapy of chronic liver diseases possible at present.

Adult↗

PubMed1986

[Modification of plasma blood coagulation factor activity by physical stress].

The influence of physical stress (bicycle ergometer and track) on 13 parameters of the plasmatic coagulation system was investigated in trained and untrained test persons. Shortenings of the coagulation times as well as distinct increases of the activity or concentration were observed in the partial thromboplastin time (PTT), the factor VIII activity (VIII:C) and the factor VIII-associated antigen (VIIIR:Ag). The results are discussed with regard to their causes and their clinical importance.

Adult↗

PubMed1984

[Skeletal muscle reaction to the loading limit. III. Changes in the contractile apparatus].

A description is given of the changes in the contractile apparatus of the skeletal muscle following extreme long-term exercise. In detail, they include Z-stripe dehiscences, myofibril disintegrations and destructions of single sarcomer . These findings are known from myopathology . A characteristic feature is their subsarcolemmic localisation. The pathogenesis is discussed. In connection with the alterations of the sarcolemma and the mitochondria as well as the increased endo- and exocytosis of the muscle fibre, the cause is seen in a local intracellular catabolism. At the same time, the possible importance to the effluence of enzymes, especially of creatine phosphokinase, is pointed out.

Adult↗

PubMed1982

Metoprolol eyedrops 3%, a short-term comparison with pilocarpine and a five-month follow-up study. (Multicenter).

A comparative study comprising 30 patients with glaucoma and 11 ocular hypertensives showed that pilocarpine 2%-4% and metoprolol 3% lowered the intraocular pressure to the same extent over a 4-week period. The magnitude of effect corresponded to 29.0% of the untreated pressure level in the pilocarpine group and to 31.9% in the metoprolol group. No statistically significant difference in the pressure lowering effect was found between glaucoma and ocular hypertension. Sufficient control of the intraocular pressure could not be achieved in approximately 35% of the patients with metoprolol single therapy and a tendency towards fading efficiency of metoprolol was noted, but no significant tachyphylaxis appeared during a 5-month follow-up period. Local irritation was the predominant side-effect of metoprolol treatment. Objective adverse reactions recorded were transient, epithelial keratopathy (3 patients) and exanthema (1 patient). Deterioration of a pre-existing visual field defect was observed in one case.

Adult↗

PubMed1982

Plasma vasopressin and oxytocin in response to exercise and during a day-night cycle in man.

Plasma vasopressin (AVP) and oxytocin (OXT) were determined by radioimmunoassay in healthy young men before, during and after a running exercise until exhaustion. In four of the five test subjects (one subject was underloaded) physical load resulted in a marked increase in plasma AVP with peak values of 11.7 to 57.8 pg/ml at exhaustion. Plasma OXT increased in three test subjects with peak values of 4.5 to 23.9 pg/ml. Within 1 h of recovery, both neuropeptides returned to basal plasma levels. The relationship between plasma AVP and osmolality (p less than 0.001) suggests that changes in osmolality play a dominant role in regulating the secretion of AVP. Besides peripheral effects, the increased levels of AVP and/or OXT during and immediately after the exercise, respectively, might induce a favourable action on the brain function. Determination of plasma AVP and OXT during a day-night cycle in the same test subjects reveals increased AVP levels from 02.00 to 08.00 h as compared to the other time periods chosen (18.00--24.00 h, p less than 0.001; 08.00--16.00 h, p = 0.031). In contrast, OXT does not differ between these time periods but decreased from 08.00 to 16.00 h (p less than 0.01). Accordingly, no correlation exists between both neuropeptides suggesting an independent secretion. It is unclear whether the circadian variations shown are able to influence the neuropeptide response to exercise.

Adolescent↗

PubMed1981