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H Bundgaard

Publications and source records attributed to H Bundgaard.

128 records · Page 8Linked to original sources

Dimensioning of the postgraduate educational training in Denmark.

BACKGROUND: Postgraduate medical training in Denmark consists of basic training, offered to all medical doctors, followed by specialist training. The National Board of Health is responsible for the overall frame of medical training in Denmark and determines the number of trainee positions for each of the 42 specialities available. The total number of positions and their distribution between specialities are based on demand, supply and demographic considerations. Approximately 85% of medical doctors finalise specialist training. METHODS: Denmark is divided into three educational regions: North, South and East. Each region consists of counties, with their own administration. The National Board of Health approves each position for postgraduate training. All new positions and changes of existing positions are evaluated before approval by The National Board of Health. An updated version of the list of educational positions is available on the internet. CONCLUSION: The Danish governmental authorities have an efficient tool to control the dimensioning of the postgraduate medical education and thereby the production of specialists. Medical doctors can easily get information about where to obtain trainee positions. The majority of hospital departments improve their recruitment potential by participating in medical training. A number of structural changes, for instance establishing of medical centres and corporations within larger entities across an extended geographic area, specialisation between hospitals and reduced number of hospitals, calls for decentralisation of the administration in order to improve flexibility in the organisation of postgraduate medical training. However, the National Board of Health will still co-ordinate at the national level.

Denmark↗

Glucuronidation of the dopamine D-1 receptor antagonists NNC 0756 and NNC 0772 in liver microsomes.

Glucuronidation of the two enantiomeric dopamine D-1 antagonists, NNC 0756 ([(+)-8-chloro-7-hydroxy-5-(2,3-dihydrobenzofuran-7-yl)-3-methyl- 2,3,4,5,tetrahydro-1H-3-benzazepine, acetate]) and NNC 0772 [(-)-8-chloro-7-hydroxy-5-(2,3-dihydrobenzofuran-7-yl)-3-methyl-2,3,4,5- tetrahydro-1H-3-benzazepine, HCl], was studied in rat and human liver microsomes. In rats, the reaction exhibited biphasic kinetics for both enantiomers as shown by Eadie-Hofstee plots. Both the high- and low-affinity reactions showed a high degree of stereoselectivity, primarily because of the large differences in Km values. For the high- and low-affinity reactions, the (-)-enantiomer, NNC 0772, had a 4- and 6-fold higher Km value, respectively. The difference in Vmax values were less significant, with 3.0- and 1.1-fold higher values for the (-)-enantiomer. Treatment of rats with known inducers of UDP-glucuronosyltransferases, phenobarbital, and 3-methyl-cholanthrene, did not change the kinetics of the reaction. Glucuronidation of the (+)-enantiomer, NNC 0756, was competitively inhibited in rat liver microsomes by the closely related structure, SCH 23388 [S-(-)-8-chloro-7-hydroxy-5-phenyl-3-methyl-2,3,4,5-tetrahydro-1H-3- benzazepine], with an apparent Ki value of 90 microM. Morphine and 4-hydroxybiphenyl, both known substrates of glucuronosyltransferase, did also inhibit the reaction with Ki values of 604 and 55 microM, respectively. In contrast to rats, glucuronidation of NNC 0756 in human liver microsomes followed Michaelis-Menten kinetics, suggesting the involvement of a single form of glucuronosyltransferase or possibly two forms, with similar affinity for NNC 0756.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗