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Biomedical subjects

H Bunko

Publications and source records attributed to H Bunko.

At least 127 records · Page 7Linked to original sources
PubMed1978

Clinical application of 201Tl scintigraphy in patients with cold thyroid nodules.

201Tl-chloride scintigraphy was performed in 45 patients with cold thyroid nodules. The 201Tl scintigram was positive in 17 of 18 thyroid patients with cancer (94.4%), 8 of 20 patients with an ademoma (40.0%), 1 of 2 adenomatous goiter patients (50.0%), and all of 5 cases of chronic thyroiditis (100.0%). When the cold nodule was demonstrated to be positive with 201Tl, the statistical chance of the lesion being a cellular one was 100.0% and a risk of its malignancy was 54.8%. On the other hand, the nodule with negative 201Tl concentration had a 14.3% chance of cellularity and a 7.1% risk of malignancy. Thus, 201Tl scintigraphy is of use in the differential diagnosis of the cold thyroid nodule.

Adenocarcinoma, Papillary↗
PubMed1978

Detection of active bleeding from ruptured aortic aneurysm by emergency radionuclide angiography.

Radionuclide angiography of the abdominal aorta provides hemodynamic information of the kidneys, aorta and aneurysm as well as the location and extent of aneurysm. Visualization of early abnormal activity in the pelvic region simultaneously with iliac artery visualization is thought to be a specific finding of active bleeding from a ruptured aneurysm of the abdominal aorta.

Aorta, Abdominal↗
PubMed1977

[Diagnosis of cold thyroid nodules by 201T1 scientigraphy].

Fifty two patients with cold thyroid nodule demonstrated on the thyroid scan were imaged with 201Tl which were given intravenously as thallium chloride in dose of 2 mCi. Thirty nine of 52 patients were confirmed and investigated whether 201Tl concentrated or not. Fourteen of 15 (93 percent) thyroid carcinomas, 5 of 17 (29 percent) thyroid adenomas, 1 of 2 adenomatous goiters and all of 5 of chronic thyroiditis were visualized as positive with 201 Tl. One thyroid carcinoma did not concentrate 201Tl which was confirmed to have cystic degeneration. Of the 19 benign cold thyroid nodules except chronic thyroiditis 6 were positively visualized with 201Tl. However, 201Tl did not accumulate in the other 13 benign nodules, 11 out of which were confirmed to have cystic degeneration. The data suggests that if the thyroid nodule is found to have negative accumulation of 201Tl, malignancy can be ruled out except a small microscopical lesion.

Adenocarcinoma↗
PubMed1976

[Advantages, disadvantages and selection methods of thyroxine measurement--comparison of CPBA and RIA].

Although recent progress in radioimmunoassay (RIA) permitted direct RIA for thyroxine (T4), there appeared few reports evaluating clinical applicability of T4 RIA as routine method. The authors evaluated advantage, disadvantage of methods for T4 measurement in comparison between CPBA (competitive protein binding analysis) and RIA, and tried to discuss about selection of methods for T4 measurement. Res-O-Mat T4 was chosen as CPBA, and RIAMAT-T4(St) and T4-RIAKIT(Sp) were chosen as RIAs. Detailed descriptions about both RIA methods appeared elsewhere [2, 3]. From the basic experiments, reproducibility of CPBA, St and Sp within assay were 5.8% (C.V.), 4.0% (C.V.), and 8.5%(C.V.) respectively, and mean recovery rates were 92.2%, 100.7% and 96.1% respectively. T4 value measured by both RIAs correlated well with CPBA, and St showed slightly lower value and Sp showed slightly higher value than CPBA. The normal ranges for RIAs were 3.7-11.7 microng% (St) and 4.6-15.2 microng% (Sp). Diagnostic accuracy for hyperthyroid state were 83.3% (CPBA), 85.7%(St) and 69.2% (Sp), and for euthyroid state were 92.0% (CPBA), 98.8% (St) and 95.7% (Sp). The diagnostic accuracy for hypothyroid state in three methods were lowest. From the economical point of view, cost performance, time performance and total time for single assay were analysed and mathematical equations were obtained from actual assay by each methods. When the number of samples per single assay was less than 10, CPBA was most economic in terms of cost and time performance and total time required. In the assay of more than 20 samples, RIAs were efficient in each point of views. In the point of view of sample volumes required, RIAs were most promising. The authors concluded that guides for selection of methods in T4 assay were as follows: A) CPBA was most efficient in local use especially when less than 10 samples were frequently to be assayed. B) RIAs were efficient in batch processing more than 20 samples, especially in automated laboratories.

Binding, Competitive↗