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Biomedical subjects

H C Børresen

Publications and source records attributed to H C Børresen.

14 recordsLinked to original sources
PubMed1998

Sudden death in two patients with epilepsy and the syndrome of inappropriate antidiuretic hormone secretion (SIADH).

We report two cases with complex partial and secondarily generalized seizures, both on oxcarbazepine and vigabatrin, with additional lamotrigine in one case. Both died in a manner resembling SUDEP, i.e. suddenly, unexpectedly, probably following a seizure with pulmonary oedema at autopsy. Both had SIADH. A number of drugs may cause SIADH, among them carbamazepine and oxcarbazepine. A search for SIADH in patients on carbamazepine and oxcarbazepine, and in cases of sudden death in epilepsy, is recommended.

Adolescent↗
PubMed1995

Rethinking current recommendations to introduce solid food between four and six months to exclusively breastfeeding infants.

The World Health Organization and UNICEF currently recommend to start weaning between four and six months and no later than six months with the gradual introduction of solid food. However, some studies show that voluntary exclusive breastfeeding for about nine months is feasible and can sustain adequate weight gain and iron status in infants. It is therefore appropriate to review and evaluate the evidence presently used to set feeding policy. It appears that the alleged insufficiency of breast milk volume after four to six months is most likely due to management errors such as introducing supplements and spacing nursing bouts at wide intervals, both of which reduce milk yield. Women in developed countries who wish to breastfeed exclusively beyond four to six months should therefore not be discouraged from doing so. In developing countries, health authorities and non-governmental organisations should actively endorse exclusive breastfeeding for eight to nine months to protect infants against malnutrition and infections.

Age Factors↗
PubMed1994

[A questionable guideline on introduction of solid food to breast-fed infants].

In 1993, the Norwegian National Nutrition Council recommended that solid food be introduced to breast-fed infants gradually between the age of four and six months, and not later than six months. A critical appraisal of the literature reveals that the alleged inadequacy of the volume of breast milk after 4-6 months is an artifact caused by the inevitable fall of milk yield induced by supplementation and unnatural time scheduling of breast-feeding. The council has overlooked evidence showing that voluntary exclusive breast feeding on demand provides enough energy and nutrients to most infants for at least nine months. There is no documented need for iron-rich solid food before the age of 7-9 months. Mothers who wish to breast-feed exclusively after the age of six months should therefore be encouraged to do so. Solid food should not be emphatically recommended until the infant is nine months old.

Breast Feeding↗
PubMed1982

Angiotensin II and renal excretion of sodium and potassium in unanaesthetized dogs.

Aldosterone is a kaliuretic hormone. It is also widely believed to be instrumental for physiological renal sodium sparing. How, then, can mammals respond to incipient dehydration or low sodium intake without inappropriate potassium loss? To study this problem angiotensin II (A II) was infused intravenously in six dogs. The dose rate was 10 ng per kg per min, probably maintaining plasma A II in the upper physiological range. The A II infusions lasted 3 h, i.e. long enough for the effects of increased aldosterone release to be observable. Mean arterial blood pressure increased by 8% while effective renal plasma flow and glomerular filtration rate fell by 28% and 7%, respectively. Renal sodium excretion fell to near 8% of the preinfusion control values. Plasma aldosterone increased three-fold. Yet no kaliuresis occurred. Potassium and chloride excretion declined by 50% and 80%, respectively. In five of the six dogs urine flow decreased 50% or more with concomitant increase of urine osmolality. Our data indicate that physiological increments of A II can bring about sustained renal sodium sparing without inducing potassium wasting.

Aldosterone↗