PubMed Health⌕ Search

Biomedical subjects

H C Cook

Publications and source records attributed to H C Cook.

9 recordsLinked to original sources
PubMed1990

Demonstration techniques in cellular pathology: putting things into perspective.

In recent years there has been a growing use of immunocytochemistry as an aid to diagnosis in cellular pathology. The value and limitations of the technique are discussed, with particular reference to the continuing need for the conventional and well-established special stains. The ways in which both forms of demonstration technique have evolved are described.

Humans↗
PubMed1982

Neutral mucin content of gastric carcinomas as a diagnostic aid in the identification of secondary deposits.

A simple quantitative method used in conjunction with the diastase digestion-Alcian blue-PAS (D-AB-PAS) technique was employed in a retrospective study of 135 gastrectomy carcinomas, and in a range of 57 unrelated metastatic adenocarcinoma cases of confirmed origin, to determine what proportion of malignant cells/glands contained neutral mucin only, as against acidic mucin or mixtures of both acid and neutral types. Fifty of the gastrectomy cases (37%) showed a high neutral mucin content of 71% or more, this feature being more evident in the diffuse (D) type of tumour. The metastatic adenocarcinoma cases comprised 35 of non-gastric origin of which eight (23%) had a high neutral mucin content of 71% or more, compared to 10 out of 22 cases of gastric origin (45%) having a neutral mucin content of 71% or more. It was felt significant that seven out of these 10 gastric cases were of the D type of tumour. The secondary adenocarcinoma of uncertain (unconfirmed) origin contained a group of cases with deposits of probable gastric origin of which more than half showed a high proportion of cells which contained neutral mucin only. The helpfulness of these findings is discussed.

Adenocarcinoma↗