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Biomedical subjects

H C Friederich

Publications and source records attributed to H C Friederich.

At least 55 records · Page 3Linked to original sources
PubMed1975

Predisposing factors on the surface of the skin in persons with pityriasis versicolor.

This is a report on biochemical and physiological examinations carried out on 20 test persons who in the last 2 years had contacted and completely recovered from pityriasis versicolor and on 25 control persons of corresponding age and sex. The tests on the skin surface of the patients with pityriasis versicolor show, when compared with the corresponding control group, the following significant results: 1. Significantly more amino acids could be extracted from the skin of the pityriasis versicolor patients than from the skin of the control persons. 2. A significantly shorter alkali neutralisation time was to be found in the pityriasis versicolor patients than in the control persons. 3. The degree of water spreading on the skin was found to be significantly reduced in the pityriasis versicolor patients when compared with the control persons. It is probable that these results point to important predisposing factors for pityriasis versicolor.

Adult↗
PubMed1975

Predisposing factors of the skin surface in persons with impetigo contagiosa.

The following report describes the results of biochemical and physiological examinations in 32 persons, who had suffered from impetigo contagiosa in the last 2 years, as well as 21 control persons of the same age and sex. The examination of the skin surface of the patient group, when compared with the corresponding control group, showed the following significant results: 1. an increase in the percentage of free cholesterol in skin surface lipids possibly as a result of an increased cell turnover in the epidermis, 2. a decrease in reducing substances as revealed by the ferricyanide and the phenolsulfuric acid methods in the so called water solubles, 3. a decrease in the alkali resistance of the skin possibly as a result of a decreased barrier function of the stratum corneum. It is most likely that these results indicate predisposing factors, localized in the epidermis, for impetigo contagiosa.

Adolescent↗
PubMed1975

Biochemical and physiological particularities on the skin surface of diabetics.

Biochemical and physiological examinations were carried out on the skin surface of the following groups: on 16 newly diagnosed diabetics; on 26 diabetics receiving treatment; and on 2 control groups of 16 and 26 healthy persons respectively of corresponding age and sex. The tests on the surface of the skin of the newly diagnosed diabetics when compared with the corresponding control group show the following significant results: 1. An increase in the percentage of free cholesterol in the lipids of the skin's surface possibly as a result of an increased cell turnover in the epidermis. 2. An increase in the free fatty acid concentration to the disadvantage of the triglycerides in the lipids of the skin's surface as an expression of an improved bacterial lipolysis. 3. A decrease in the reducing substances as confirmed by the phenol-sulfuric acid method in the so called water solubles. 4. An increase in the amino acids as confirmed by the ninhydrin method in the so called water solubles. All the above mentioned changes were more pronounced in the newly diagnosed diabetics than in those already receiving treatment; it can be seen that these changes can partly be normalised under diabetic therapy.

Aged↗
PubMed1975

Biochemical and physiological parameters on the skin surface of healthy test persons: a contribution towards the interpretation of the results obtained by a screening program.

Biochemical and physiological examinations were carried out on the skin surface of a total of 115 healthy persons ranging from the age of 7-79 years. In these investigations the following striking findings were made: 1. There is a significant correlation between the results obtained by the ferricyanide, the phenol sulfuric acid and the ninhydrin methods in the so called water solubles. 2. The relationship between the fraction of wax and cholesterol esters and the squalene fraction in the skin surface lipids influences the release of free fatty acids by bacterial lipases. 3. With regards to most parameters tested there are great differences between the 8-12 year age group and the older age groups. 4. There are significant differences in the 8-12 year age group between the male and female test persons. 5. With regards to the parameters tested there are also significant differences between the various test areas.

Adolescent↗
PubMed1975

[Hair growth on pedunoular skin flaps in the guinea pig].

In animal experiments with 12 male guinea pigs skin defects have been covered with one-sided bridge flaps. As opposed to corresponding earlier investigations on free full thickness skin autografts no irreversible and much less reversible damage to the hair follicles could be demonstrated in these skin flaps in the primary postoperative phase. In the later postoperative phase, there was--similar to the free full thickness skin autografts--a synchronization of hair change over several cycles, but on the other hand there was no precipitation of hair change. As a result of these findings it may be assumed that the secondary damage to the hair follicles in the later postoperative phase is not as pronounced in these flaps as in free full thickness skin autografts.

Animals↗
PubMed1975

[The effect of bath additive concentration and the water temperature on the refatting effect of oil bath additives].

The refatting effects of three different oil bath products was tested in 30 healthy subjects. In each case the concentration of the therapeutic bath oils and the temperature of the bath water were varied. It could be demonstrated in 2 of the tested products that a threefold increase in the concentrations (as recommended by the companies) significantly enlarges the refatting effect. A further increase in the concentrations significantly reduces this effect. An increase in the temperature of the bath water from 32 degrees to 38 degrees C significantly lessened the refatting effects of all 3 products.

Aged↗
PubMed1975

[Physiology of the free-skin transplant].

The publications on the physiology of the free full thickness skin autograft are reported with special reference to the newer ones as a synopsis of literature. Emphasis is placed upon the interesting findings on plastic surgery and especially upon the operative treatment of alopecia.

Graft vs Host Reaction↗
PubMed1975

[On the influence of a special preparation of oxytetracycline and sodiumbituminosulfonates on amount and composition of skin surface lipids in acne vulgaris (author's transl)].

Two groups of 27 and 23 patients with acne vulgaris were first treated for a period of one week with 1 g oxytetracycline a day p.o. In a second treatment period of 6 weeks the first group received 100 mg oxytetracycline a day p.o. and the second group a combination of 100 mg oxytetracycline and 1.2 g sodiumbituminosulfonates a day p.o. In the third treatment period, similarly continued for 6 weeks, the method was reversed. Gastric juice-insoluble preparations were used for the investigation. All criteria for a double-blind study were considered. Amount and composition of the skin surface lipids were analysed before beginning the treatment, at the end of the 2nd and at the end of the 3rd treatment period. The combination of both agents in gastric juice-insoluble preparations suppresses to a great extent the known effects brought about by the substances separately, namely the reduction in free fatty acids and the decrease in the skin surface lipids. The findings also show that the reduction of the free fatty acids was in a limited time observed only in patients treated with 100 mg oxytetracycline a day p.o. if they had been treated in the beginning of this therapy with a higher dosage of tetracycline.

Acne Vulgaris↗