PubMed Health⌕ Search

Biomedical subjects

H C Grice

Publications and source records attributed to H C Grice.

51 records · Page 3Linked to original sources
PubMed1966

Comparative pathologic and hematologic effects in various species fed cholesterol and fats.

The hematologic response in various animal species fed cholesterol and fat differed with the species and sex. Male rabbits, chickens and guinea pigs could not adequately comensate for the demand for increased red cell production and developed anemia. Female guinea pigs given added cholesterol and fat maintained adequate blood cell production but may have become anemic if the test period had been extended. Bone marrow production was increased in male rats and was sufficient to compensate for red cell loss. Blood and bone marrow values were not altered in female chickens by the dietary treatment. Fatty changes in the liver were common to all species fed added cholesterol and fat but gastric lesions were seen only in the rabbit.

Anemia↗
PubMedDate not supplied

Monitoring animal health during chronic toxicity studies.

Adequate and appropriate appraisal of the health of the animals in toxicity studies is required to differentiate between toxic manifestations attributable to the test material and non-treatment-related disease. The appraisal will help to ensure that each animal remains on test for as long as reasonably possible and that useful tissue samples are obtained from each animal. Attainment of this objective requires highly motivated personnel who have undergone a specific and continuous training program. The establishment of protocols and procedures for daily and weekly monitoring of the animals, and an efficient and relevant system for data collection, recording, and storage is also required. Various laboratory and clinical procedures are described which may be used either on a routine basis or as diagnostic tools. By following the described procedures it has been possible to reduce the loss of animal tissues due to autolysis to less than 1% during chronic feeding studies.

Animal Husbandry↗