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Biomedical subjects

H C Gunga

Publications and source records attributed to H C Gunga.

At least 37 records · Page 2Linked to original sources
PubMed1996

Shift working in the Chilean Andes (> 3,600 m) and its influence on erythropoietin and the low-pressure system.

It was hypothesized that, in shift workers with a history of intermittent hypoxic stress (working 10 days at > 3,600 m, then resting for 4 days at sea level) for > 5 yr, the initial erythropoietin (EPO) response and the changes in central venous pressure (CVP) are different from those in Caucasian lowlanders. We studied the kitchen personnel (n = 11) of a mine (3,600 m) and a group of Caucasian lowlanders (n = 5). Blood samples were taken, and CVP was determined several times before, during, and after a typical shift. At baseline data collection (BDC) before transition, the shift workers had EPO concentrations of 5.2 +/- 2.4 mU/ml, which increased at altitude (P < 0.01) and returned to BDC values on the recovery (day 16). The Caucasians showed the same time course. Serum transferrin receptor concentrations did not change in either group. CVP values were generally higher in the shift workers than in the Caucasians. In conclusion, the hypothesis that the initial EPO response to a hypoxic stimulus is altered in these shift workers has to be refuted. Higher hemoglobin concentrations and/or CVP values in shift workers might be responsible for the rather low EPO concentrations in shift workers at BDC.

Acclimatization↗
PubMed1996

Influence of maximal ergometric exercise on endothelin concentrations in relation to molecular markers of the hemostatic system.

The effects of moderate 30 min cycle ergometer exercise (aerobic metabolism; 0.85-3.71 mmol.1(-1) lactate) followed by short-term exercise at maximal capacity (anaerobic metabolism; 5.09 to 17.75 mmol.1(-1) lactate) on endothelin (ET) and hemostatic variables (tissue plasminogen activator [t-PA] antigen, prothrombin fragments [F1,2], thrombin-antithrombin III complex [TAT], prothrombin time and partial thromboplastin time) were investigated in 15 male healthy subjects of varying fitness levels. Endothelin was measured twice before and immediately after maximal cycle exercise. The results show an increase in endothelin concentration [10.0 pg.ml-1 (baseline) + 6.1 pg.ml-1 (increase post exercise)]. ET did not increase under control conditions. Moderate 30 min exercise caused an increase in t-PA antigen concentration (3.66 + 3.15 ng.ml-1) and short-term maximal exercise produced a markedly higher elevation in this variable (+10.6 ng.ml-1). F1,2 increased (810 + 40 pmol.l-1) under moderate and by 150 pmol.l-1 under anaerobic exercise. TAT increased only at maximal exercise levels (1.01 + 0.32 ng.l-1). No changes were found in any of these variables under control conditions. No correlation of endothelin and the hemostatic variables was found. It is concluded that endothelin and hemostatic markers increase independently during moderate and maximal exercise.

Adult↗
PubMed1995

Fluid distribution and tissue thickness changes in 29 men during 1 week at moderate altitude (2,315 m).

To quantify fluid distribution at a moderate altitude (2,315 m) 29 male subjects were studied with respect to tissue thickness changes [front (forehead), sternum, tibia], changes of total body water, changes of plasma volume, total protein concentrations (TPC), colloid osmotic pressure (COP), and electrolytes. Tissue thickness at the forehead showed a significant increase from 4.14 mm to 4.41 mm 48 h after ascent to the Rudolfshuette (2,315 m) (P < 0.05). At 96 h after ascent the tissue thickness at the tibia was decreased to 1.33 mm compared to the control value of 1.59 mm (P < 0.01). Body mass increased from 75.5 kg (control) to 76.2 kg on the last day (P < 0.05) and body water from 44.21 to 45.01 during the week (P < 0.01). The accumulation fluid in the upper part of the body was paralleled by a decrease in TPC and COP. At 48 h after the ascent COP dropped from 29.5 mmHg to 27.5 mmHg (P < 0.01). After 96 h at moderate altitude COP was still significantly decreased compared to the control level. At 1.5 h after the return from the Rudolf-shuette in Saalfelden (744 m) COP was back to the control values. The TPC also showed an initial drop from 7.75 g.dl-1 to 7.48 g.dl-1 after 48 h at altitude and remained below the control value during the whole week (P < 0.01). It seems from our study that even with exposure to moderate altitude measurable fluid shifts to the upper part of the body occurred which were detected by our ultrasound method.

Acclimatization↗
PubMed1995

Blood volume regulating hormones response during two space related simulation protocols: four-week confinement and head-down bed-rest.

The volume of regulating hormones (renin, aldosterone, arginine vasopressin and atrial natriuretic factor), electrolytes and creatinine concentrations, and blood pressure were measured in two different four-week experimental protocols: respectively -6 degrees head-down bed-rest (5 subjects) and confinement (6 subjects). We observed a significant increase (P < 0.01 at D2 vs D-5) of systolic blood pressure during confinement and a different level of response for some hormones, especially for arginine vasopressin (300% increase during confinement instead of 50% during bed-rest). The renin-angiotensin-aldosterone system was enhanced during confinement and head-down bed-rest. In both conditions, we obtained a similar pattern of response for blood volume regulating hormones. During confinement, two main factors were inactivity and stress activation of the sympathetic nervous system. In the bed-rest study the response is principally due to the fluid shift and blood volume adaptation but it is not possible to exclude the role of inactivity and stress.

Adult↗
PubMed1995

Hormonal regulation during a 60-day confinement (ESA-EXEMSI'92) in humans.

EXEMSI'92 was a 60-day isolation and confinement experiment with an international crew. During this second experiment of the European Space Agency (the first one was a 28-day confinement with 6 men: ISEMSI'90), blood volume regulating hormones and water balance were studied. During ISEMSI'90, stress level was elevated as shown by specific markers and we observed some interesting results which have been already observed before, during bed-rest experiments. Thus, our conclusion was that some of the physiological effects observed during bed rest could be the consequence of the "confinement effect" and/or stress imposed to the subjects during such experiments. The aim of the present physiological study was: 1/to define the origin of the blood pressure increase seen during ISEMSI'90; 2/ to study the blood volume regulating hormones (ANP, renin, aldosterone) variations; 3/ to determine the dehydration level by measuring the total body water with the doubly labeled water (DLW) method and fluid balance in general.

Aldosterone↗
PubMed1995

Nathan Zuntz (1847-1920)--a German pioneer in high altitude physiology and aviation medicine, Part I: Biography.

Nathan Zuntz (1847-1920) was a key person in the history of high altitude physiology and aviation medicine. As a professor of animal physiology at the Landwirtschaftliche Hochschule (Agricultural University) in Berlin from 1881 until 1918, he carried out laboratory studies on the changes in metabolism at rest and during exercise. To this end he, together with August Julius Geppert, developed the famous "Zuntz-Geppert'schen Respirationsapparat" (Zuntz-Geppert respiratory apparatus) in 1885. In the early 1890's, Zuntz extended his research to the field of high altitude physiology. In view of the variety of questions, and despite considerable methodological problems, Zuntz first studied the effects of lowered PO2 on the human body in a Pneumatischen Kammer (hypobaric chamber). In 1893 the newly completed Capanna Regina Margherita, an international research station at the top of Monte Rosa, Italy (4,500 m), became the site of Zuntz's extensive field studies, where he worked together with his close co-worker Adolf Loewy (1862-1936), the Italian Angelo Mosso (1846-1910), and the Austrian Arnold Durig (1872-1961). For their investigations Zuntz invented the transportable Gasuhr (a gas exchange measuring device). In 1902 Zuntz and the Austrian Hermann von Schroetter (1870-1928) made two balloon ascents up to 5,000 m in Berlin. A synopsis of these studies was published by Zuntz in 1906: his famous book "Höhenklima und Bergwanderungen" (High altitude climate and mountain-touring). A few years later Zuntz undertook further expeditions to the Canary Islands (Pico de Teide), conducting studies in airships and planes until 1914. Zuntz retired in 1916 and died in Berlin on March 22, 1920.

Aerospace Medicine↗
PubMed1995

Nathan Zuntz (1847-1920)--a German pioneer in high altitude physiology and aviation medicine, Part II: Scientific work.

For over 52 years, the work of Nathan Zuntz (1847-1920) covered an amazingly wide spectrum of research fields; metabolism, nutrition, respiration, blood gases, exercise, and high altitude physiology were the main themes. Zuntz achieved fame for his invention of the Zuntz-Geppert respiratory apparatus in 1886 and the first Laufband (treadmill) in 1889. To this experimental setup Zuntz later added an X-ray apparatus in 1914 to determine the changes in heart volume during exercise. Moreover, he constructed a climate chamber to study exercise under varying and sometimes extreme climates. For field studies Zuntz invented a transportable Gasuhr (dry gas measuring device). Zuntz was the first to describe the difference between laboratory data gained in a hypobaric chamber and the measurements at high altitude. He found that the barometric formula is not applicable in the field. Two balloon expeditions in 1902 by Zuntz and his pupil, v. Schroetter, marked the step from terrestrial physiology towards aviation medicine. An outline of the development of scientific aviation in Berlin from 1880-1918 elucidates how closely the aviation union, army, and scientific departments were connected with and dependent upon each other. In cooperation with these institutions Zuntz and v. Schroetter constructed an oxygen supply system and planned a pressure cabin for extreme altitudes above 10,000 m, a forerunner of modern systems in aviation and astronautics. In 1912, Zuntz and v. Schroetter each published papers on aviation medicine, both publications internationally unique in style and extent. Zuntz's work in its empirical approach was the counterpart to the established formal mathematical-physical reductionism of the German Physiological Society.(ABSTRACT TRUNCATED AT 250 WORDS)

Aerospace Medicine↗
PubMed1994

Enhanced slow caudad fluid shifts in orthostatic intolerance after 24-h bed-rest.

To evaluate mechanisms of late orthostatic intolerance, slow fluid shifts along the body axis were studied during deconditioning by 24-h bed-rest and during 13-min upright tilts before and after this manoeuvre. In 11 healthy male subjects the fluid volumes of a thorax and a calf segment (impedance plethysmography) as well as tissue thickness at the forehead and the tibia (miniature ultrasonic plethysmograph) were recorded. Cardiovascular performance was monitored by recording heart rate (electrocardiogram), brachial and finger arterial pressure (by the Riva Rocci method and by the Finapres technique) as well as stroke volume (by impedance cardiography). Bed-rest led to a cephalad fluid shift with a mean interstitial leg dehydration of 2.2 ml.100 ml-1 with no changes in body mass and plasma volume. No syncope during the tilt occurred before bed-rest, while after bed-rest 8 subjects fainted between min 2.1 and 9.0 of the tilt. Bed-rest resulted in an augmented initial heart rate response to tilting which was similar in all subjects. In later orthostasis, bed-rest caused two- to threefold faster caudad fluid shifts with higher calf filtration rates in fainters (prior to hypotension) than in nonfainters. Through bed-rest the estimated extravasation within 10 min into general lower body tissue spaces increased by 192 ml in (late) fainters as opposed to only 23 ml in nonfainters. It was concluded that contributing factors to orthostatic intolerance may be slow transcapillary fluid shifts which are easily underestimated and whose quantity and time course call for further investigation after various deconditioning manoeuvres. In particular, the postflight fluid shifts in astronauts who will have markedly dehydrated legs, may impose a circulatory stress which needs to be evaluated. In general, the filtration rate in relevant areas appears to be an integrative and easily determined parameter, reflecting hormonal and neurogenic vascular as well as local interstitial control of the Starling forces.

Adult↗
PubMed1994

Time course of erythropoietin, triiodothyronine, thyroxine, and thyroid-stimulating hormone at 2,315 m.

Erythropoietin (EPO), triiodothyronine, thyroxine, thyroid-stimulating hormone (TSH), hemoglobin (Hb), reticulocytes, packed cell volume, and plasma volume changes were studied in 29 male Austrian mountain rescue soldiers before and several days after an ascent from 744 to 2,315 m in the Alps. EPO concentrations showed a remarkable increase 48 h after the ascent (P < 0.01). No significant changes were found in triiodothyronine, thyroxine, and TSH. Reticulocytes increased only slightly. Hb decreased during the week (P < 0.01). Packed cell volume did not change, whereas plasma volume showed a slight decrease for 48 h after the ascent but then increased constantly (P < 0.01). It seems that thyroid hormones, TSH, and Hb play only a minor role in the regulation of EPO production and release under mild hypobaric-hypoxic conditions (2,315 m).

Adult↗
PubMed1994

Fluid recruitment from shell tissues of the body during haemodialysis.

Patients with kidney failure are prone to accumulate fluids within the superficial tissues, leading to a puffiness of the face, hands, and feet. After dialysis these symptoms disappear. It was the aim of this study to quantify these changes. With the help of A-mode ultrasound in 49 patients (20 females, 29 males) the tissue thickness in the forehead and tibia was measured during dialysis. In the forehead the tissue thickness before dialysis was 4.01 mm (females) and 3.87 mm in the males, decreasing continuously during dialysis by 13.6% and 12.8% respectively (P < 0.001). In the tibia the tissue thickness was 3.87 mm (females) and 3.07 mm (males) and decreased by 12.8% and 23.9% respectively. The sex difference was significant (P < 0.05). From these values it was calculated that 45% of fluid withdrawn came from the superficial shell tissues of the body. It was concluded that these tissues serve as water stores in the interdialytic phase.

Adult↗
PubMed1993

Fluid shifts into and out of superficial tissues under microgravity and terrestrial conditions.

The microgravity environment can be expected in man to induce a swelling of facial tissues and a shrinking of the tissues in the lower limbs together with a loss in body weight. To quantitate fluid shifts into and out of superficial tissues an ultrasound A-mode method was used in one cosmonaut during a 7-day spaceflight. Measurements were taken from frontal and tibia tissues, where the underlying bone provides a good backwall echo. During the spaceflight the cosmonaut showed a swelling of facial tissues during the first 3 days. At the same time the superficial tissues of the caudal areas shrank by 20%. In space he lost 7.7% of body weight. After the spaceflight the superficial tissues were dried out but regained their water content within the next 4 days even before body weight returned to control level. Per kilogram of body weight an increase of 400 cm3 entered the superficial tissue layers of the body. It is concluded that water loss as well as wasting of tissues contribute to the loss in body weight during space flight.

Body Fluids↗
PubMed1993

Transient blood/plasma density and hematocrit effects after passive (sitting) thermoneutral water immersion in men.

At the beginning and with ceasing of suction which is exerted upon the lower parts of the body, we have recently discovered transient hemodilution/hemoconcentration effects by use of the high-precision so-called mechanical oscillator technique. Since transient effects are useful for biological systems analysis, we addressed the question if such transients in blood and plasma mass density also occur with and immediately after water immersion in humans. Water immersion (WI) has been used as an analog of microgravity conditions. The effects on blood volume depend on the test conditions, particularly body position before immersion, and the time of measurement. Consequently, hemodilution has been found as an early effect of WI in many but not all studies. If test persons are immersed after sitting or standing on air, WI counteracts postural hemoconcentration and consistently produces a decrease in hematocrit, hemoglobin, and plasma protein concentration and, hence, plasma and blood mass density. In this paper we present evidence that, like with termination of lower body suction, there might be transient hemoconcentration in the first minutes of thermoneutral WI in a sitting position in men, but no evidence could be obtained for any counterdirected transient hemodilution when test subjects are passively brought out (in sitting position) from the water, as was found with starting lower body suction (in supine position).

Blood Viscosity↗
PubMed1993

European isolation and confinement study. Water and salt turnover.

Intake and output of water were studied in six male subjects from six European countries during 28 days of isolation and confinement in order to assess whether the observed reactions can be compared with those observed during space travel. On the average, the subjects drank 17.5 ml/kg/day fluids. An additional 25 ml/kg/day was recruited from food intake and metabolism. The lowest fluid intake of 11.3 and 12.1 ml/kg/day was shown by two subjects who concurrently lost 3 to 4% of body weight. Three subjects maintained body weight, and one subject gained. A linear correlation existed between the total water output and the fluid intake by drinking. The time series of fluid intake, urine output, and sodium excretion revealed a weekly pattern for these parameters, characterized by low values on Sundays and high values on Fridays. This pattern was most apparent for sodium excretion. Low water turnover rates were seen in the first week of isolation; in the last week the values were above average. In conclusion, it can be said that with respect to the water balance, strong individual differences and time dependent variations (day to day, week to week) of the respective parameters have to be taken into account for the data analysis during such long-term studies.

Adult↗
PubMed1993

European isolation and confinement study. Blood pressure, volume-regulating hormones, and electrolytes.

In the ISEMSI confinement experiment we observed three main reactions concerning blood volume regulation: first, a stress activation produced by the high workload that the subjects had to accomplish, both before the isolation period and during the two first weeks of isolation; second, a typical defense reaction to the environment occurred, at least during the two initial days of isolation and later perhaps between crew members themselves; and third, a change in blood volume regulating hormone levels may have been the result of the increase of sympathetic system activity and of dehydration. Confinement is certainly a good and valid method to simulate space station life (with the absence of weightlessness). So, it is interesting to use these confinement studies to perform biological and physiological experiments to obtain greater knowledge, but also to prepare and validate new scientific protocols or new scientific equipment suitable for spaceflights. Even more so, confinement is a good way to prepare and train crew members for long-term space missions. It would seem desirable to confirm the scientific results obtained during the ISEMSI campaign, and especially those for the regulation of the blood volume. This will be done during the next confinement experiment, called EXEMSI, in which four subjects will be subjected to 60 days of confinement.

Adult↗
PubMed1993

Effects of 28-day isolation (ESA-ISEMSI'90) on blood pressure and blood volume regulating hormones.

The aim of this study was to determine what effects social isolation and confinement stress had on the volume regulating hormones. In six healthy male subjects, during a 28-d isolation and confinement study (ESA-ISEMSI'90), hematocrit, blood pressure and resting heart rate, plasma cortisol, renin, aldosterone, arginine vasopressin levels besides the electrolyte (Na+, K+) balance and plasma creatinine were measured. During the confinement, an elevated systolic blood pressure (p < 0.01) was observed together with an increase in MHPG corresponding to an elevated mental work load. The pattern displayed by volume regulating hormones (increased values for renin, aldosterone (p < 0.05) and arginine vasopressin) was not only characteristic of confinement stress but also reflected changes in the water and electrolyte metabolism. The increased creatinine levels seen throughout the study were regarded as consequences of hypohydration, and an enhanced muscular catabolism due to reduced physical activity. A similar pattern of hormone modifications was obtained in a head down tilt of the same duration, indicating that some of the described modifications are probably related to isolation and confinement stress.

Adult↗