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H C ROWSELL

Publications and source records attributed to H C ROWSELL.

At least 19 recordsLinked to original sources
PubMed1964

THROMBOSIS.

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Anticoagulants↗
PubMed1962

The occurrence of microthrombi on the aortic endothelium of swine.

Evidence is presented in this report that microthrombi composed chiefly of platelets form on what appears to be morphologically normal swine endothelium and that the pattern of the deposits corresponds to that in analogous flow-chamber models, and to the lesions in the early stages of swine atherosclerosis. Since mural thrombi occur in young swine, it seems reasonable to suggest that this is to some extent a normal process. The cumulative effects of such a process could be a factor in the primary as well as the late stages of atherosclerosis.

Animals↗
PubMed1962

Encrustation and atherosclerosis: the analogy between early in vivo lesions and deposits which occur in extracorporeal circulations.

A study was made of the relation between the pattern and topography of thrombus formation in models of various vessel configurations coupled into extracorporeal shunts in swine and the development of atherosclerosis at corresponding sites on swine aortas. The pattern and distribution of deposits formed in the models were strikingly similar to the pattern and distribution of incipient atherosclerosis at comparable sites in the vascular tree. The earliest and only consistent component of the flow chamber deposits was the blood platelet. The platelet deposits would frequently stain with oil red O. The cholesterol level of washed human platelets was found to show a good correlation with that in the plasma. This evidence suggests that deposition of particulate matter (chiefly platelets), largely determined by the hydraulic factors, may be an important factor in the early, as well as later, stages of atherosclerosis.

Animals↗