Suppressive effect of anti-allergic mediators on experimental encephalomyelitis.
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Animals↗
Biomedical subjects
H C Rauch
Publications and source records attributed to H C Rauch.
Histopathologic evaluation following chronic implantation of chromium and steel based metal alloys in the rabbit central nervous system.
Histopathologic evaluation of three metal alloys for chronic implantation in the central nervous system (CNS) was undertaken in rabbits. Throughout the 8 month evaluation period the inflammatory response to the alloys was bland. Two of the alloys tested (chromium based MP35N, Trademark of the Standard Pressed Steel Company, and a stainless steel alloy, BG42 VacArc, Trademark of Latrobe Steel) appeared suitable as CNS implants. The third alloy (stainless steel 440C, Carpenter Steel Company) showed more corrosion than the other alloys, and may be less suitable for implantation. While E. cuniculi infection was found in four rabbits, the infection did not directly interfere with the assessment of the histologic changes directly due to the implants. Autoantibodies to a brain constituent were not observed.
Animals↗
Prenatal cocaine exposure in the laboratory mouse: effects on maternal water consumption and offspring outcome.
Pregnant mice were given 50 mg/kg cocaine HCl (1% solution, sc) once daily from gestation days 7 through 18 (sperm positive = day 0; term = day 19). Pair-fed and untreated control groups were also used. The pregnant cocaine-treated females showed normal weight gain and food consumption but had significantly increased water consumption. The cocaine-treated group had a significant increase in embryonic resorptions but no significant effects on stillbirths or postnatal mortality. The offspring of cocaine-treated females had significantly reduced birth weights and postnatal weight gains up to the age of 28 days. There was also a delay in their ear opening but not in other maturational milestones. Increased water consumption following cocaine treatment has been reported by other studies. We speculate that cocaine has a diuretic effect. We discuss the implications of this effect during pregnancy.
Analysis of Variance↗