Deep mycoses in patients with abnormal chest X ray findings.
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Biomedical subjects
Publications and source records attributed to H Campins.
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Using a radioimmunoassay technique, we have determined the total IgE concentration and specific IgE antibody level against Paracoccidioides brasiliensis in the sera of patients with mycologically confirmed active paracoccidioidcosis. Patients with aspergilloma, or individuals with antibodies against Cadida albicans, and sera of apparently healthy individuals from the endemic area were also examined. The level of total IgE was significantly elevated in 9 out of 10 cases of paracoccidioidomycosis. The mean level of specific IgE against P. brasiliensis was significantly higher in the serum of the patients in comparison with control individuals. The percentage of specific IgE relative to the total varied from 0.38 to 2.28%. The differences between IgE levels in pare other mycoses were statistically significant. Our results suggest a possible involvement of specific IgE antibodies against P. brasiliensis in the immune response of patients with paracoccidioidomycosis. The hyperimmunoglobulinemia E may be related to the T-cell defect that characterizes the severe forms of the disease.
A tumor like case of Cryptococcosis with a rare location in the abdomen of a young healthy woman is commented. It gave the opportunity to refer to the pathogeny of the disease, making in that way a brief review of the cases known in Venezuela and some not still published from which we got information. That review showed that generally doctors found more frequently organic lesions within the fields they are specially working for. It is obvious that mycosis must be considered in the diagnosis of nearly every patient in many countries and that laboratories must get appropriate equipment and personnel to help in that diagnosis.
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