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H Chardon

Publications and source records attributed to H Chardon.

At least 37 records · Page 2Linked to original sources
PubMed1989

[In vitro effect of cefixime against 200 strains of Branhamella catarrhalis. Comparison with cefotaxime].

The in vitro activity of cefixime was tested against 200 strains of Branhamella catarrhalis. Of these strains, 146 had been collected during 1987 from 15 different "Centres hospitaliers généraux", through a multicenter collaborative investigation organized by the "Collège de Bactériologie-Virologie-Hygiène des hôpitaux généraux". The remaining 54 strains were isolated at the "Centre hospitalier", of Aix-en-Provence. The strains originated from: bronchopulmonary collections: 80.2 per cent, sinusitis: 5.6 per cent, conjunctivitis: 4.6 per cent, otitis: 3.5 per cent, blood cultures: 0.5 per cent, miscellaneous: 5.6 per cent. Seventy-three per cent of the strains produced beta-lactamases. MIC determination was performed according to the agar dilution procedure on non-enriched Mueller-Hinton agar (30 hours incubation at 37 degrees C without CO2). The inoculum was 10(5) CFU per spot. Non beta-lactamase producing strains displayed the following MIC 50 and MIC 90 values (mg/l): amoxicillin: 0.03 - 0.125; cefotaxime: 0.06 - 1; cefixime: 0.06 - 0.5. Beta-lactamase producing strains were generally more resistant: amoxicillin: 32 - 128; cefotaxime: 1 - 2, and cefixime: 0.5 - 1.

Amoxicillin↗
PubMed1989

[In vitro comparative activity of five macrolides against 190 Branhamella catarrhalis strains].

We compared the in vitro activity of 5 macrolides against 190 strains of Branhamella catarrhalis; 48 strains were isolated at Centre Hospitalier, Aix-en-Provence, the 142 others were isolated during 1987, in 15 different Centres-Hospitaliers-Généraux in France. 153 strains were betalactamase producing strains; no difference in susceptibility to erythromycin was observed on betalactamase producing and non producing strains. Three active macrolides against 100% of strains were: erythromycin (MIC 50 = 0.25 mg/l - MIC 90 = 0.50 mg/l), roxithromycin (MIC 50 = 0.50 mg/l - MIC 90 = 0.50 mg/l) and josamycin (MIC 50 = 0.50 mg/l - MIC 90 = 1 mg/l); A lower activity was noted on midecamycin (mic 50 = 2 mg/l - MIC 90 = 2 mg/l) and spiramycin (MIC 50 = 4 mg/l - MIC 90 = 8 mg/l).

Carbon Dioxide↗
PubMed1987

[Diagnostic value of 4 biological markers: lactate dehydrogenase, phosphoglucoisomerase, carcinoembryonic antigen and gammaglutamyl transpeptidase, systematically determined in patients in a hematology-oncology department].

This article is concerned with a prospective study about the systematical, simultaneous and comparative assay of four biological markers (carcino-embryonic antigen, lactate dehydrogenase, gammaglutamyl transferase and phosphohexose isomerase). This study was conducted in a department of Hematology and oncology on 258 patients. The dosage of each marker separately does not appear to be of diagnostical interest because of a lack of sensibility and specificity. But when there is a positive statistical correlation between several makers, their simultaneous dosage may allow the diagnostic of cancer and sometimes the determination of its origin.

Adult↗
PubMed1983

[Serotype and antibiotic resistance of pneumococci isolated at the Aix-en-Provence Hospital Center].

Over a 2 year period from April 1980 to April 1982, 240 pneumococci isolated from amongst 208 patients during 216 infectious episodes were serotyped. Sensitivity to standard antibiotics was determined for 209 of these strains. Pneumococci are divided into 33 serotypes. The vaccination cover provided by the vaccine currently commercially available is 70%. AUSTRIAN and GESLIN feel that the surveillance of bacteraemias is the most effective method for the choice of vaccine formula in order to eliminate the bias due to healthy carriers. In the present study, pneumococci isolated from 41 bacteraemias came from 14 serotypes and vaccine cover was 90%. Amongst 209 strains of Streptococcus pneumoniae, 25.8% were resistant to tetracyclines, 10.5% to sulphonamides, 6.6% to chloramphenicol, 5.7% to erythromycin, 2.8% to co-trimoxazole and none to penicillin.

Anti-Bacterial Agents↗
PubMed1976

New plasmid-mediated nucleotidylation of aminoglycoside antibiotics in Staphlococcus aureus.

A wild-type strain of Staphylococcus aureus, which inactivates a wide variety of aminoglycosides (except the gentamicin components), has been found to harbor a plasmid (RAp01) that mediates the biosynthesis of a nucleotidyltransferase. This enzyme modifies the 4'-hydroxy function of these antibiotics. The plasmid has been studied, the enzyme responsible for this resistance pattern has been isolated by affinity chromatography, and its kinetics and physicochemistry have been characterized. The target of this enzyme has also been located by demonstrating the structure of one inactivated compound, 4'-(O)-adenylyltobramycin.

Aminoglycosides↗