[Graham-Little and Lassueur syndrome].
Explore the source record for details and available documents.
Biomedical subjects
Publications and source records attributed to H Chatard.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Extensive secondary eczema of the legs and chronic venous insufficiency coexist fairly often ; among aetiological factors are considered atopy and multiple sensitivities, contact dermatitis, and eczematizations of infective origin (bacterial or fungal) from organisms with weak pathogenic potency but strong allergenic potency. There is a short clinical description referring to the phenomena of primary irritation and controlateral extensions of the eczema. The pathogenesis relates to immunological phenomena and antigen-antibody conflicts. These types of eczema come for the most part into the category of delayed hypersensitivity type IV of the Gell-Coombs classification.
Corticosteroid therapy has not revolutionised phlebology but it is very useful in certain cases. The following indications are considered, with or without associated antibiotics : anaphylactic shock after sclerosant injections, chronic lymphangitis of the lower limbs, sclero-inflammatory hypodermatitis, eczemas, phlebitis, ulcers and angiomas. Various forms of corticosteroid therapy are considered ; injectable, long-acting, local and oral.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Venous pigmentations are not only tissue deposits of extravasated haemosiderin. Histology reveals that these deposits are often accompanied by excessive melanocyte activity. This combination of various sorts of pigmentation, haematic and melanic, is also found in other non-phlebological ferric hyperchromias. The excess of iron appears to be responsible for the hypermelanosis, but the mechanism is not understood.
This article concerns sclerotherapy techniques. It deals with varicosity of the large or samll saphenous veins and their treatment using sclerosing injections in cases where, for various reasons, the decision not to undertake surgery is made. The following points are successively considered: --management of the treatment: from top to bottom, that is, from the proximal to the distal segment of the varicose vein; --the dose of the sclerosing drug utilized and the relation between the amount and the concentration of the injected doses; --the position of the patient and various movements aimed at injecting the solution in a patient when he is lying down, even if the needle is introduced when he is standing up; --the spasm-inducing capacity of certain sclerosing drugs and the possible utilization of provoked veinoconstriction during treatment for better contact between sclerosing drugs and endothelium; --finally, retention with straps: they are put in place immediately after treatment, maintained from 8 to 15 days without interruption, have little or no elasticity and are non-detachable.
The author deals only with the sclerous subcutaneous inflammation caused by venous stasis. There is no clear distinction between inflammation, and tissular sclerosis, the final stage of its development. There may be a certain lesional reversibility. The term "scleroinflammatory cellulitis" is therefore quite apt. Physiopathology. Pathology venous reflex results in a flood of proteins in the interstitial tissue, and this shows in signs of tissular pain, especially at the level of the hypoderm and dermis (anatomical reasons). Clinical. This is most often in the case of women with varicose affections or with post-phlebitic syndromes causing a painful, inflamed plaque, on the surface of the inside leg, at the junction of the middle and lower thirds. As well as the inflammation of this area, adhesion to the subjacent layers and induration are also confirmed. Venous dilations may be detected at the centre of this scleroinflammatory plaque. To begin with, the skin is red and taut, but later becomes dry and atrophic. It is prone to eczema and sometimes to ulceration. The development of subcutaneous inflammation is marked by sudden manifestation of inflammation which may be extensive and results in circular suffing, in extreme cases. Varicose sclerosis can provoke sudden manifestations of inflammation and especially if the technique is faulty (excessive dosage, lack of compression, insufficient compression). Treatment. 1. Local. Bandaging and walking are imperative. The bandage must be compressive, immovable, durable, and should be reinforced as necessary at the site of the induration, by latex rubber pads. Once the object of these slightly or non-elastic pads has been achieved they can be replaced by elastic contention. 2. General. Corticoids and phenylbutazone in short courses of treatment. Other products constitute auxiliary remedies. Thermal cures are always indicated in difficult cases. Medical treatment is often enough. In certain perverse cases a surgical treatment may be required, such as hypodermal resection and ligation of the perforants. Grafts (Vigoni). Certain severe cases remain unresponsive to all treatment and in such cases it is regrettable that suitable treatment was not administered at an earlier stage.
The aim of the treatment if to remove the consequences of a rupture of the vasculo-tissular balance in a varicose of post-phlebitic limb: these consequences consist of inflammatory phenomena which develop towards a hypodermic sclerosis more, or less, serious. The authors review the therapeutic possibilities of resting in the declivous position, which is sometimes indicated, the different procedures and ways of using compression, which is always indicated, antibiotics which may sometimes be used, anti-sclerosants and crenotherapy. The bibliography refers to this question.
The elementary physiology of the venous circulation of the lower limbs allows a ready understanding of the favourable effects of muscular exercise and sport in patients with venous insufficiency. However varicose veins may be produced or aggravated by sporting excesses (vicarious varices) or by the choice of certain sports (post-traumatic and post-thrombic varices). In patients with varicose veins and long reflux, sport is more encouraged than in patients with varicose veins and short reflux or patients with post-phlebitic syndrome, except when well adapted bandaging apparatus is used. Sports should be chosen in which the muscular effort is rhythmic and dynamic, while sports in which the effort is static are discouraged. Finally, in order to be useful rather than harmful to patients with venous insufficiency, the practice of sports should be carefully adjusted in amount.