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Biomedical subjects

H Chmielewski

Publications and source records attributed to H Chmielewski.

At least 19 recordsLinked to original sources
PubMed1997

Evaluation of myocardial muscle functional parameters in patients with multiple sclerosis.

Structural and functional parameters of myocardium were evaluated with 2D+ Doppler echocardiography in two similar age groups of MS patients: S1: 12 subjects in 3-4 Degrees EDSS (Expanded Disability Status Scale), S2: 12 subjects in 5-7 degrees EDSS. The control group comprised 12 healthy subjects temporarily (at least 1 month) immobilized due to lower limb fractures. Investigations were performed in the supine position and 3 min after tilting to the erect position. Symptoms of organic myocardial injury which might have caused its insufficiency were not observed in any subjects. All structural parameters evaluated by this method did not differ significantly in the examined groups. Symptoms suggesting myocardial insufficiency were found in patients from group S2. Statistically significant decrease of ejection fraction (EF) and cardiac output (CO) was observed in the supine position of S2 patients as compared to S1 and the controls. These symptoms intensified in the erect position in S2 patients and they were accompanied by the decreased values of stroke volume (SV). The fact that in the majority of patients orthostatic hypotonia was not observed and that those disorders were not compensated by significant intensification of heart rate suggest to us that besides disorders resulting from autonomic nervous system dysfunction they may have been caused by secondary myocardial injury in the course of MS.

Adult↗
PubMed1995

Activities of acetylcholinesterase and NA+, K+ -ATP-ase in human erythrocytes after ethanol consumption.

The influence of ethanol consumption on acetylcholinesterase (AchE) and Na+, K+ -ATP-ase activities was examined in 14 healthy volunteers after 30 minutes of ethanol treatment at a dose 0.6 g/kg of body weight. It was observed that the activity of both enzymes decreased. The activity of AchE was significantly lower, and that of Na+, K+ -ATP-ase tended to be lower, but the difference was not significant. In vitro experiments showed that ethanol inhibited the AchE and N+, K+ -ATP-ase activities immediately and in proportion to the concentration of ethanol used.

Acetylcholinesterase↗
PubMed1994

[Effect of gamma radiation on levels of adenine nucleotides in erythrocytes of healthy individuals after submaximum physical exertion].

The authors studied the effect of gamma radiation and submaximum physical exercise on adenosine-5'-triphosphate (ATP), adenosine-5'-diphosphate (ADP) and adenosine-5'-monophosphate (AMP) contents in erythrocytes of healthy males. Twenty one men aged 20-22 years were examined. They underwent physical exercise at doses of 2 w/kg body weight for 15 min. Erythrocytes were exposed to gamma radiation (500 gy doses) from 60Co source. The concentration of adenine nucleotides in erythrocytes was measured by the Boehringer Mannheim tests. The submaximum physical exercise was found to decrease ATP content and to to increase ADP and AMP in erythrocytes. Gamma radiation at 500 Gy dose was found to decrease ATP concentration in erythrocytes both at rest and after submaximum exercise and to increase AD content. It was revealed that AMP content increased at rest and decreased after submaximum exercise in irradiated erythrocytes.

Adenosine Diphosphate↗
PubMed1993

[Effect of gamma radiation on the concentration of pyruvate and lactate in erythrocytes of healthy men after submaximal physical exercise].

The aim of this work was to study the effect of gamma radiation and submaximal physical exercise on the concentration of final products of anaerobic glycolytic pathway in erythrocytes of healthy men. Twenty one men aged 20-22 were examined. They underwent physical exercise at doses of 2 w/kg body weight for 15 min. Erythrocytes were taken in the rest and after physical exercise and were exposed to gamma radiation (500 Gy doses) from 60Co source. The concentration of pyruvate was estimated by Fermognost tests and the concentration of lactate by Boehringer Mannheim tests. The submaximal physical exercise was found to cause a significantly increased concentration of pyruvate and lactate in the non-radiated and irradiated erythrocytes. Gamma radiation at 500 Gy dose was found to increase concentration of pyruvate in erythrocytes (in the rest and after physical exercise) with simultaneous decrease of lactate concentration.

Adult↗
PubMed1989

[Retinitis in multiple sclerosis].

A 37-year-old man treated since 6 years for multiple sclerosis is described because retinitis developed in an exacerbation of the disease. Retinitis was treated successfully with penicillin and hydrocortisone.

Adult↗
PubMed1989

[Morphological and functional condition of the stomach in multiple sclerosis patients treated with prednisone].

In 30 patients with multiple sclerosis treated with prednisone the morphological status of the gastric mucosa was assessed endoscopically and microscopically, and the secretory function of the stomach was studied determining hydrophloric acid, sialic acid and total glycoproteins in gastric juice before and after 6 weeks of prednisone treatment. After the treatment in 9 cases the symptoms and signs of gastritis were exacerbated, in 7 cases they were alleviated, and in gastric juice secretion of sialic acid was reduced in most cases.

Adult↗
PubMed1984

Red blood cell glutathione peroxidase activity in multiple sclerosis.

Glutathione peroxidase (GSH-Px) activity of red blood cells of 23 multiple sclerosis (MS) patients (10 men and 13 women, aged 22-64 years) was examined and compared to the enzyme activity of 26 healthy persons (15 men and 11 women, aged 19-50 years). It was found that the mean GSH-Px activity was significantly higher (P less than 0.001) in red blood cells of MS patients (39.1 +/- 8.1 IU/g Hb) as compared to the group of healthy persons (25.9 +/- 5.2 IU/g Hb). There was no difference according to sexes in both the MS patients and the control group. The results are discussed based on the hypothesis that organic peroxides play a role in the etiology of multiple sclerosis.

Adult↗