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Biomedical subjects

H Conradi

Publications and source records attributed to H Conradi.

10 recordsLinked to original sources

Adenocarcinoma arising in Crohn's disease: report of two cases.

Crohn's disease of the colon and small bowel is associated with a greater-than-chance increased incidence of adenocarcinoma, which also differs from the norm in age and anatomic distribution. The cancer risk appears to rise with earlier age of onset and long duration of the granulomatous disease, and the prognosis is relatively poor, probably due to difficulty in diagnosis because of the overlapping Crohn's disease. Two additional cases of adenocarcinoma arising in Crohn's disease are described.

Adenocarcinoma↗

Regional distribution of vascular resistance in two models of experimental renovascular hypertension.

The regional distribution of the peripheral vascular resistance was studied in normotensive and hypertensive Wistar rats. Two models of experimental hypertension were investigated: (I) in 32 animals the right renal artery was constricted by a silver clip (two-kidney Goldblatt hypertension); (II) in 46 animals the left kidney was removed and the right renal artery was clipped as in the first group (one-kidney Goldblatt hypertension). The normotensive control group comprised 61 untreated animals of the same strain and age. The distribution of cardiac output to 14 tissues was determined by means of the particle distribution technique. The resistance was increased in all regions investigated, a decreased or unchanged resistance was not observed. For most of the investigated tissues the regional resistance was increased exactly in proportion to the total peripheral resistance (TPR). Exceptions to this were found in 2 regions where the change of local resistance deviated from that of TPR: the splanchnic area and the skeletal muscle. In both cases the 2 models differed from each other. In the two-kidney model the increase of resistance in the splanchnic circulation was more intense than in other organs. In contrast, in the one-kidney model the local change of resistance was less than that of TPR. The change of skeletal muscle resistance was not significantly different from the change of TPR in the two-kidney model, while in the one-kidney model the increase of local resistance was significantly higher than that of TPR. It is concluded that the etiology of the abnormal resistance is different in the 2 models investigated and that known extrinsinc pressor factors may play a role in the two-kidney, but not in the one-kidney Goldblatt hypertension.

Abdomen↗

[Synchronization of estrus in heifers with BOVISYNCHRON].

Heifers were each given 2ml of 1% solution of chlormadinone (CAP, Bovisynchron) for 15 days. Those in group I received one daily dose, while group II received half the dose twice a day. Oestrus was synchronized in all but two heifers. In group II there was a concentrated occurrence of oestrus, so that all heifers could be inseminated on the 5th and 6th days, and earlier inseminations were not needed. This decreased the time required and the number of semen pellets. Results of insemination in two of the three subgroups of group II were 51% in one and 61% in the other, compared with between 32 and 39% in the other subgroup and in group I. Ways of improving the results are discussed.

Administration, Oral↗

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