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Biomedical subjects

H Conrads

Publications and source records attributed to H Conrads.

At least 19 recordsLinked to original sources
PubMed1984

[Pros and cons of preservatives in eyedrops. Questionnaire for practitioners and experimental studies with reference to the requirements of the German Pharmacopoeia of August 1978].

The first part of this paper deals with the regulations in the DAB 8/78 stating that eye-drops are to be preserved. A questionnaire prepared by the German Association of Ophthalmologists is analyzed. The four questions put to 353 ophthalmologists and answered by 350 of these concern the need for unpreserved eye-drops because of the danger of allergization; the expiry date once the bottle has been opened; infections due to eye-drops without preservatives; and the need for eye-drops made up by pharmacists. The second part deals with studies on the pH-values of lacrimal fluid in cases of normal and decreased lacrimation, as well as with the bactericidal action of the normal tear fluid containing lysozyme and lactotransferrine and various eye-drops containing preservatives. The authors conclude that the general addition of preservatives to eye-drops, especially to those containing antiphlogistic and astringent substances, is unnecessary. Concerning the expiry date on the bottle, it is suggested that the period of use be extended to three months, thus helping to cut costs.

Drug Hypersensitivity↗
PubMed1983

[Multiple vitelliform retinal cysts].

The authors report on a case of multiple vitelliform retinal cysts which were observed by chance during an examination for an expert opinion on a bulbar contusion. It is shown that these cysts are hard to recognize by simple ophthalmoscopy, but may be visualized by fluorescein angiography in the form of bright circular areas, sometimes differently colored. The developmental mechanism is illustrated with histologic pictures.

Cysts↗
PubMed1983

[Changes in the cornea following complicated pseudophakia and subsequent keratoplasty (clinical and scanning electron microscope findings)].

An anterior chamber lens (Binkhorst four-loop lens) became dislocated seven weeks after implantation. It was relocated in the right position by means of a small incision. In the course of the following 8 weeks the cornea opacified from the top downward. A penetrating keratoplasty was performed. Intraoperatively it was found that a strand of vitreous had pushed forward between the iris and the lens and was adhering to the back of the cornea. The piece of cornea removed was prepared for the scanning electron microscope. The microscopic findings are described in detail. They correspond exactly to the clinical diagnosis of complete tearing of the endothelium, considerable bullous changes in the parenchyma and degenerative changes in the epithelium. The scanning electron microscope reveals how severe pathologic changes in the cornea can become if a strand of the vitreous becomes adherent to the endothelium.

Cataract↗
PubMed1983

[Etiology and pathogenesis of recurrent erosions of the cornea. A scanning and transmission electron microscopy study].

Scratched off corneae of 2 patients were examined under the scanning electron and the transmission electron microscope. Whereas in the scanning electron microscope the expected picture of the destruction of the epithelium in the upper zones of the cornea could be presented in the 1st case, the histological picture of the 2nd case shows in the transmission electron microscope the reaction of the influence of the noxa to the texture of the epithelial cells, to the protoplasm, and to the nucleus of the concerned epithelial cell.

Adult↗
PubMed1981

[Total aniridia: a problem of bulbus rupture (author's transl)].

In two cases of total aniridia after contusion of the eyeball, small perforating wounds near the limbus were found. The entire iris can only have become detached from the eye as a result of this very small wound. The theory concerning the cause of total traumatic aniridia is discussed.

Adult↗
PubMed1981

[Electron-microscopic examinations in cases of keratitis dendritica (author's transl)].

Scanning electron-microscopic and transmission electron-microscopic examination of cornea affected with herpes simplex (DNS) and which developed the clinical picture of keratitis dendritica, showed typical test results, which are described in detail. The ultramicroscopic findings show that the metabolism of the epithelial cells is of considerable degree. It was proved that there were virus particles in the protoplasm of the epithelial cells. A comparison with a case of zoster keratitis showed the same morphological changes.

Cornea↗
PubMed1979

[Risk of transmission of hepatitis B through contact lens fitting set].

8 out of 19 cases of acute or chronic hepatitis, with positive hepatitis B surface antigen (HBsAg) had HBsAg-positive tears. In 25 healthy HBsAg carriers, no HBsAg was found in the tears. The HBsAg concentration in the tears of hepatitis patients was less than 1% of the HBsAg in their blood. Contact lenses (soft hydrophilic, silicone) experimentally contaminated with HBsAg were practically free of it after the usual cleaning and washing with a commercial contact lens cleaning fluid. No adsorption of HBsAg was found on hydrophilic soft lenses; a minimal adsorption on silicone lenses could not be entirely excluded, but practically it was without any importance. In 14 samples of 79 storage fluids of a contact lens fitting set HBsAg was found. The cause of this contamination is not clear.

Acute Disease↗
PubMed1976

[Observations on the treatment of glaucoma with clonidin (author's transl)].

Observations on 50 patients treated for up to 2 1/2 years with clonidin revealed very variable side-effects. A large proportion of these patients remained free from side-effects. In a second, bigger group the side-effects decreased so markedly during the treatment, that this drug could be used again. The effects of this drug on the patients are reported in each case.

Adult↗