Retroperitoneal and inguinal manifestation of malignant fibrous histiocytoma.
Explore the source record for details and available documents.
Adolescent↗
Biomedical subjects
H D Adolphs
Publications and source records attributed to H D Adolphs.
[Importance of serum and urine CEA determinations in the diagnosis of bladder cancer].
Explore the source record for details and available documents.
Carcinoembryonic Antigen↗
[Results of chemoimmune prophylaxis of superficial bladder carcinoma (author's transl)].
41 patients with superficial urothelial bladder cancer were subjected to chemoimmune prophylaxis with i.v. cyclophosphamide and intravesical as well as systemic BCG treatment, after complete tumor resection. Compared with a historical patient control group treated by tumor resection alone, the chemoimmune treatment group exhibited a distinct reduction of the recurrence rate. This difference was most marked during the first 6 months postoperatively. The side effects of this treatment were tolerable. Our results are discussed with regard to the reported findings in the literature. Possible immune biological mechanisms of the tumor protection achieved by cyclophosphamide/BCG are suggested.
Adult↗
Treatment of idiopathic varicoceles by transfemoral testicular vein occlusion.
Percutaneous transfemoral occlusion of the testicular vein is a new alternative in the treatment of idiopathic varicocele. Embolization with the Gianturco coil was done on 27 patients. The occlusion was performed immediately after diagnostic phlebography. The results of followup for 1 year are available for 18 patients. In 1 patient the coil had to be removed because of persistent pain, although cause and effect could not be proved. Two patients had a recurrence. The urographic findings were normal 1 year after embolization. No dislocation of the foreign body was observed. Two patients reported that their wives were pregnant.
Adolescent↗
Inhibition of experimental bladder tumor induction by systemic BCG treatment.
Transitional cell carcinoma of the urinary bladder was induced in rats by ingestion of 0.188% N-[4-5-nitro-2-furyl)-2-thiazolyl] formamide. During the induction period of 8 months, one animal group received systemic BCG treatment. After 12 months, the BCG-treated rats showed a significantly lower bladder tumor weight and stage than the corresponding controls. The results are discussed with regard to the possibility of BCG prophylaxis of human bladder tumors.
Animals↗
[Surgical therapy of germinal testicle tumors (author's transl)].
Surgical intervention in patients with germinal testicular tumors is performed to obtain the exact tumor histology and to define the stage of disease. This can be achieved by inguinal orchiectomy and retroperitoneal exploration. In cases without metastases, a modified retroperitoneal lymphadenectomy (LA) can reduce operative morbidity. With regard to the juvenile age of the patients, protection of ejaculation is of particular importance. If retroperitoneal lymph node metastases are present radical LA should be performed. In case of infiltration of ureters or kidney pedicles a coincident of nephrectomy becomes necessary. Palliative primary surgery should be avoided by exact preoperative diagnosis. In patients presenting with primary inoperable tumors chemotherapy should be instituted prior to surgery. A more radical treatment is necessary if residual tumor has to be removed in a second look operation or after chemotherapy, respectively. Resection of metastases is particularly indicated in cases with mediastinal or pulmonary spread.
Antineoplastic Agents↗
[Epidemiology and pathogenesis of bladder cancer].
First, all known etiologic factors for the development of urinary bladder cancer and those being in discussion are summarized. Consideration is essentially given to industrial carcinogens, tryptophan metabolites, phenacetin, nicotine, coffee, artificial sweeteners, and chronic irritations of the bladder urothelium. In addition, the demographic factors known from the literature, such as familial, geographical, sexual, and racial dispositions are discussed. Another section focuses at the early histological changes of bladder urothelium until tumor manifestation. Especially the significance of the carcinoma in situ is emphasized.
Humans↗
[Significance of biological markers for the diagnosis of urinary bladder cancer].
Several substances are discussed which possibly may play a role as biological markers in urinary bladder cancer, such as the carcinoembryonic antigen, some proteins, amino acids and their metabolites as well as enzymes. The significance of these serum and urine measurements for the diagnosis of bladder cancer is critically reviewed.
Humans↗
Significance of supraclavicular lymph node biopsy for staging, therapy and prognosis of testicular tumors.
Supraclavicular lymph node biopsies were performed in 40 patients with germinal testicular tumors. The radiologic visualization of both the thoracic ducts and the supraclavicular lymph nodes was reviewed and no relation to retroperitoneal lymph node involvement was found. In 5 patients with retroperitoneal but without distant metastases, supraclavicular lymph nodes revealed tumor metastases, two of which had been clinically suspected. Depending on the staging system applied, the tumor stage had to be changed in 1 or 3 patients, respectively. For comparison, in 4 patients with distant metastases no metastatic involvement of the supraclavicular nodes was demonstrable. It is concluded that supraclavicular tumor spread is not indicative of distant metastasis and incurability. Therefore, in these cases primary radical surgery should not be considered contraindicated.
Biopsy↗
Effect of intralesional and systemic BCG-application or a combined cyclophosphamide/BCG treatment on experimental bladder cancer.
Infiltrating transitional cell carcinomas of the urinary bladder were induced by ingestion of 0.188% N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide (FANFT) in 145 female Wistar rats. After 8 months of carcinogen exposure, the animals were divided into different treatment groups. They received cyclophosphamide intraperitoneally as a single injection or BCG either once intralesionally or weekly subcutaneously or a combination of cyclophosphamide followed by subcutaneous BCG. The treatment effect was determined by body weight measurements and bladder tumour weight after 12 months. Compared with a control group statistically significant differences of bladder tumour weights were found after treatment with BCG alone or in combination with cyclophosphamide. Intralesional BCG resulted in an insignificant increase of tumour weights.
Animals↗
Avian pox virus. An ultrastructural study on a cherrug falcon. Brief report.
The ultrastructure and maturation of avian pox particles is described in the rare case of a naturally infected hawk (Falco cherrug). As in other cells infected by fowlpox virus two types of inclusion bodies are encountered in the cytoplasm: firstly assemblies of fluffy filamentous material apparently giving rise to immature virions. They are thought to present virus factories (inclusion body B). Secondly mature virus particles budded into extensive groupings (Bollinger bodies, inclusion body A) which display a fine structure identical to other strains of fowlpox virus.
Animals↗
[Nephrogenic adenoma of the urinary bladder with concomitant multiple adenomatous polyps of the large bowel. An abortive form of Gardner's syndrome? (author's transl)].
For the first time, a nephrogenic adenoma of the urinary bladder coinciding with multiple adenomatous polyps of the large bowel, in a 64-year-old male, is reported. The relationship of these tumors at different sites to a known clinical systemic disease is questionable; they could conceivably be ascribed to an abortive form of Gardner's syndrome. On the basis of a case report, the essential aspects of the nephrogenic adenoma of the urinary bladder are reviewed and discussed.
Adenocarcinoma↗
The natural history of nephrogenic adenoma of the urinary bladder.
The nephrogenic adenoma is a peculiar lesion of the urinary bladder characterized partly by villous and partly by gland-like structures. The two layered surface epithelium consists of an eosinophilic cell layer, which covers a clear cell layer, the latter resting upon a delicate basal layer. The clear cells disappear when approaching the tip of the villi. There exists a 200 micron wide zone of transition between the urinary bladder epithelium and that of the neprogenic adenoma. At the base of the villi there are scattered nodules of gland-like structures lined either by eosinophilic cells or by clear cells. These epithelial cells are derived from the corresponding surface epithelial cells from which they had separated by active downwards growth.
Adenoma↗
Induction of transitional cell carcinoma of the urinary bladder in rats by feeding N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide. Histological and ultrastructural findings.
After feeding with 0.188% N-[4-(5-nitro-2 furyl)-2-thiazolyl] formamide (FANFT), transitional cell carcinoma of the urinary bladder was induced in all female Wistar rats tested. Histological changes of the urothelium consisted of various degrees of hyperplasia and dysplasia. An infiltrating transitional cell carcinoma first appeared after 8 months. These results are compared with the findings of other authors, and divergencies of the tumour induction rates are discussed with respect to strain, sex and weight of experimental animals as well as concentration and amount of ingested carcinogen. Electron microscopy shows microvillous transformation of the luminal plasma membrane and appearance of a thick fluffy cell coat (glycocalyx). These changes are explained by an altered function of the Golgi complex occurring during malignancy and leading to a loss of the specific discoid vesicles of the urothelial cells.
Animals↗
Biological behavior of N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide induced carcinoma of the transitional epithelium in the rat.
30 female Wistar rats weighing between 70 and 90 g were fed for 8 months with 0,188% N-[4-(5-nitro-2-furyl)-2-thiazolyl] Formamide (FANFT). After this period a papillary tumor of the urinary bladder was demonstrable in each animal. Histological examination always revealed a transitional cell carcinoma with prevailing medium tumor stages; no distant metastases were found. The grade of malignancy was classified as medium and high. No significant statistical relationship could be ascertained between tumor stage and grade or between grade and weight, but a correlation was established between tumor stage and weight. After 12 months, 36/60 kidneys were found to be normal, whereas in 20/60 dysplasias and in 2/60 transitional cell carcinomas of the renal pelvis were observed; secondary hydronephrosis due to bladder tumors occured 4 times. Other organ changes were not noticeable.
Animals↗
[Malignant lymphoma of the testis--an urological or nonurological disease?[].
Malignant lymphomas of the testis have a special position among the tumours of the testis. Also in such cases, in which only the testis is perceptibly diseased, nevertheless must be started from a systemic disease which is clinically not yet recognizable. These special problems demand a multidisciplinary, oncological collaboration in diagnostics and therapy. After establishment of the diagnosis and semicastration by the urologist further diagnostics and therapy should be performed by the representatives of other specialities.
Adolescent↗
[Primary tumors of the ureter (author's transl)].
13 own cases of primary tumors of the ureter are presented and discussed with reference to the presenting clinical symptoms, diagnostic procedures, and therapy. In our patients, excretory urography was not always of diagnostic value, whereas retrograde pyelography contributed to the correct diagnosis. The radiographic appearance of ureteral tumors has to be differentiated from strictures. In one case with a calcified papilloma, preoperative roentgendiagnosis suggested an ureteral stone.
Adult↗