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Biomedical subjects

H D Kerr

Publications and source records attributed to H D Kerr.

At least 37 records · Page 2Linked to original sources
PubMed1988

Posterior tibial tendon rupture.

A patient initially presented with pain in the instep and medial malleolar area swelling after an eversion injury. The pain was described as "fiery" and failed to resolve with conservative measures. Ankle and foot radiographs were normal. The patient returned several weeks later with complaints of continued pain and of disturbed gait, the latter due to unilateral flatfoot and a sensation of loss of control of the involved foot. At surgery an incompetent posterior tibial tendon was found and repaired.

Ankle Injuries↗
PubMed1988

Dyspnea possibly associated with controlled-release morphine sulfate tablets.

Morphine sulfate in controlled-release tablet form is a relatively new oral preparation being used for the relief of chronic severe pain, such as that related to cancer. A patient with adenocarcinoma of the prostate with bone metastases experienced dyspnea possibly related to the ingestion of these tablets. Discontinuing the drug quickly resulted in disappearance of the dyspnea. The respiratory effects of morphine and the particular risks posed to the elderly patient are discussed.

Adenocarcinoma↗
PubMed1988

Cleidocranial dysplasia.

An elderly man who presented with severe kyphoscoliosis and congestive heart failure is described. The latter was treated in a standard manner, and he improved accordingly. Radiologic investigations of his obvious cranial and skeletal abnormalities revealed cleidocranial dysplasia. The characteristics and diagnosis of this rare autosomal dominant disorder are discussed.

Aged↗
PubMed1986

Prehospital emergency services and health maintenance organizations.

Described are the cases of three acute cardiac patients and their referral to the emergency department by two health maintenance organization triage systems. The HMOs' methods did not use existing emergency medical services systems, and by policy virtually discouraged free use of the emergency medical services system. The patients required hospitalization and extensive ED treatment.

Adult↗
PubMed1986

Arsenic content of homeopathic medicines.

In order to test the widely held assumption that homeopathic medicines contain negligible quantities of their major ingredients, six such medicines labeled in Latin as containing arsenic were purchased over the counter and by mail order and their arsenic contents measured. Values determined were similar to those expected from label information in only two of six and were markedly at variance in the remaining four. Arsenic was present in notable quantities in two preparations. Most sales personnel interviewed could not identify arsenic as being an ingredient in these preparations and were therefore incapable of warning the general public of possible dangers from ingestion. No such warnings appeared on the labels.

Arsenic↗
PubMed1984

Pulmonary function adaptation to ozone in subjects with chronic bronchitis.

Twenty smokers with chronic bronchitis were exposed to 0.41 ppm ozone for 3 hr-day for 5 consecutive days and reexposed 4 days later to determine (1) if they are sensitive to ozone, (2) if they adapt, and (3) if the adaptation lasts longer than 4 days. There were significant decrements in forced vital capacity (FVC) and forced expiratory volume in 3 sec ( FEV3 ) on the first day of the 5-day repeated exposures and also on reexposure 4 days following cessation of the sequential exposures. Symptoms experienced were mild and did not predominate on any exposure days. These results suggest that individuals with chronic bronchitis adapt rapidly to ozone and lose this adaptive phenomenon within 4 days. The small decreases seen in FVC and FEV3 (less than or equal to 3%) appear to impose no more than minimal limitations on their daily activities.

Adaptation, Physiological↗
PubMed1984

Vocal cord hematomas complicating anticoagulant therapy.

Described are the cases of two patients who presented with vocal cord hematomas consequent to poor control of anticoagulation. Both patients presented with hoarseness and cough. One required intubation due to respiratory obstruction. Vocal cord hematomas should be considered in patients who present with upper airway symptoms while anticoagulated.

Aged↗
PubMed1984

Sulfur dioxide and ammonium sulfate effects on pulmonary function and bronchial reactivity in human subjects.

The effect of exposures to 1 ppm sulfur dioxide (SO2) and 500 micrograms/m3 respirable ammonium sulfate [(NH4)2SO4] was studied in 20 nonsmoking subjects to determine if a response can be measured at these atmospheric levels and if the response is additive or synergistic. Four-hour separate and combined exposures were employed. Each subject acted as his or her own control and performed two light-to-moderate exercise stints (612 kg-m/min) for 15 minutes on each day's confinement in the environmental chamber. Pulmonary function tests (body plethysmography and spirometry) and bronchial reactivity to methacholine were performed to assess the response of these exposures. No significant changes in pulmonary function or bronchial reactivity were observed in the individual exposures [(NH4)2SO4 or SO2], the combined exposure [(NH4)2SO4 and SO2], or 24 hours post-exposure. This study design and the observed results did not demonstrate any readily apparent risk to healthy subjects with these exposures. Since no significant changes were measured, it was not possible to conclude if these two pollutants in combination produce an additive or synergistic response.

Adult↗
PubMed1982

Duration of pulmonary function adaptation to ozone in humans.

The duration of pulmonary function adaptation subsequent to cessation of a 5-day repeated ozone (O3) exposure was studied in 24 nonsmoking human subjects. A three-week, 3 hr/day study was conducted. The subjects received filtered air on Week 1 and 0.4 ppm O3 on Week 2. During Week 3, 13 subjects were re-exposed to O3 on Friday and 11 were re-exposed to O3 on Tuesday. Spirometric measurements (FVC and FEV1) and bronchial reactivity to methacholine showed adaptation within 2-3 days of the repeated daily exposures (Week 2). Although the duration of adaptation seen with bronchial reactivity appears longer than 7-days, the FVC and FEV1 clearly demonstrated complete loss of adaptation by 7 days, with a trend toward significance by 4 days. We conclude, therefore, the loss of ozone adaptation in pulmonary function is a gradual phenomenon lasting less than 7 days following cessation of repeated daily exposures.

Adaptation, Physiological↗
PubMed1982

Pulmonary function and bronchial reactivity in human subjects with exposure to ozone and respirable sulfuric acid aerosol.

The effect of 0.3 ppm ozone with a subsequent exposure to 100 micrograms/m3 sulfuric acid aerosol was studied in 12 nonsmoking subjects to determine if preexposure to ozone would sensitize them to sulfuric acid aerosol. Pulmonary function and bronchial reactivity measurements were made after single and sequential exposures to these pollutants. No significant changes in pulmonary function or bronchial reactivity to methacholine were observed. However, a decrease in bronchial reactivity approaching significance occurred after the 4-h exposure to 100 micrograms/m3, 0.13 microns sulfuric acid aerosol. We conclude that there are no readily apparent risks from sequential exposures of nonsmokers to low concentrations of ozone and sulfuric acid aerosol during light-to-moderate exercise.

Adult↗
PubMed1979

Adaptation in human subjects to the effects of inhaled ozone after repeated exposure.

Single exposures to low concentrations of ozone (0.4 to 0.5 ppm) have resulted in decrements in forced vital capacity and specific airway conductance. To establish whether adaptation might occur with repeated exposure, 14 normal human subjects were exposed on 5 consecutive days to 0.4 ppm of ozone for 3 hours per day in an environmental chamber. Measurements of forced vital capacity and specific airway conductance obtained after exposure to ozone were compared to corresponding control values obtained during the previous week, when the same subjects breathed filtered air in the environmental chamber for 3 hours per day on 5 consecutive days at the same time of day. The forced vital capacity was significantly lower than the control value on the first 3 days of exposure to ozone, but there was no significant difference on the fourth and fifth days. Specific airway conductance was significantly lower than the control value on the first and second days of exposure to ozone; no significant difference was noted on the third, fourth, or final day. All subjects were symptomatic on the first and second days of exposure to ozone. Symptoms resolved thereafter, with only one subject remaining symptomatic on the final day of exposure to ozone.

Adaptation, Biological↗