British Photodermatology Group Workshop. Predictive in vitro methods for identifying photosensitizing drugs: a report.
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Biomedical subjects
Publications and source records attributed to H D Menagé.
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The action spectrum for induction of the abnormal cutaneous response at 24 h in the photosensitivity disorder chronic actinic dermatitis (CAD) was determined in 15 patients and found to be the same in shape as that for normal sunburn in fair-skinned individuals at 24 h, as determined for 47 control volunteers, although displaced in magnitude. This suggests that an endogenous chromophore(s), the same as or similar to that/those responsible for human sunburn, may be responsible for initiation of the abnormal reaction to irradiation in CAD, and that the putative antigen associated with the CAD reaction may be derived from that/those or associated molecules.
Psoralen photochemotherapy (PUVA) was effective in the treatment of five patients with aquagenic pruritus, associated in one with polycythaemia rubra vera and in another with the myelodysplastic syndrome. Relapse occurred within 2-24 weeks when treatment was discontinued. Maintenance therapy or a further course of PUVA was necessary to maintain remission. This requirement may limit the value of the therapy.
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