[The history of pharmaceutical science. 21. The contribution of Erwin Rupp to the development of pharmaceutical sciences].
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Biomedical subjects
Publications and source records attributed to H D Rosenbaum.
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Thirty-one magnetic resonance (MR) scans and computed tomography (CT) scans were obtained on 25 patients in whom lesions involving the sella turcica or parasellar region were clinically suspected. Surgical pathologic studies were available in 19 cases. Twenty-two of the MR scans were of diagnostic value equivalent to that of the corresponding CT studies. In two small meningiomas, an empty sella, and a sphenoid-middle fossa tumor, MR technology failed to delineate the pathologic process adequately. In the remaining five patients, MR either more convincingly demonstrated the pathologic anatomy or yielded diagnostic information not present in the CT study. In view of the absence of ionizing radiation, high degree of tissue contrast and spatial resolution, and multiplanar capability, magnetic resonance scanning will probably become the initial imaging modality of choice in patients suspected of harboring sellar and parasellar tumors.
This study was undertaken to investigate the relative merits of magnetic resonance (MR) imaging and computed tomography (CT) in the evaluation of primary lesions of the cerebral ventricles. Since 1982, 14 patients, 7 males and 7 females, aged 8 to 68 years were diagnosed as harboring ventricular mass lesions. Eight masses were located in the lateral, 5 in the third, and one in the fourth ventricle. The diagnostic contribution and relative merits of two imaging modalities were compared in each case. In 57 per cent of cases the CT scan was of superior diagnostic value, and in 21 per cent of the patients MR imaging proved to be either more sensitive or specific than CT scanning. The availability of intravenous contrast agents for CT and not MR, as well as the capability of CT to definitely identify lesion calcification, accounted for the better performance of CT scanning in this series of patients.
Noncardiogenic pulmonary edema occurs in 35% of salicylate-intoxicated patients who are over 30 years old. Cigarette smoking, chronic salicylate ingestion, a component of metabolic acidosis, and the presence of neurological symptoms on admission are strong risk factors for the subsequent development of pulmonary edema in the appropriate age group. In the absence of these risk factors, salicylate-induced pulmonary edema is rare. The etiology is multifactorial, but it centers around altered vascular permeability in the lungs.
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The authors, during repeated visits and a sabbatical period, participated in the initiation of a program to train radiologic technologists in Nicaragua. The training program, its objectives, and the level of development of Nicaraguan radiology in 1977-1978 are described. The results achieved and problems encountered are discussed. Although the training was effective, all of the goals could not be accomplished because of political unrest. Nevertheless, lessions were learned and conclusions reached concerning future efforts to improve radiologic services in countries such as Nicaragua. These relate to economics, language barriers, governmental control, and the attitudes of native physicians and radiologists.
Pelvic lipomatosis has a classic roentgen triad which includes (1) pelvic radiolucency, (2) elevation of an intact rectosigmoid, and (3) elevation of the urinary bladder. This triad, in the absence of other abnormal clinical and roentgen findings, is pathognomonic of pelvic lipomatosis, and surgical biopsy is not necessary to confirm the diagnosis.
Although an aberrant left pulmonary artery, usually called a pulmonary sling, is a serious anomaly in neonates and young children, it can be seen initially in adulthood. To date, all adult patients have been without symptoms or associated anomalies. Radiographic findings are somewhat different in adults, although at both ages a soft tissue mass is visible between the esophagus and the distal trachea. In adults, the anomalous left pulmonary artery is more likely seen as a right-sided mediastinal mass on the posteroanterior chest film. A pulmonary sling is apparently a benign and asymptomatic condition in adults.
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A 59 year old while female with striking carpal and tarsal osteolysis is reported. The process primarily involves the carpals and tarsals but includes other sites. The pertinent literature is reviewed and a simplified classification of idiopathic multicentric osteolysis is presented. Idiopathic multicentric osteolysis may be sporadic but can demonstrate either dominant or recessive inheritance. There may or may not be associated nephropathy. The underlying mechanism appears similar in all variations of this condition. Gorham's disease, the Winchester syndrome, and other osteolytic conditions which may predominantly affect the tarsal and carpal bones most likely are totally different processes, unrelated to idiopathic multicentric osteolysis.
Data are presented which indicate that specially selected ART students can be trained to evaluate radiographs as to the presence or absence of significant pathology with an accuracy equivalent to that of experienced staff radiologists. The methods employed in this training program-namely, stressing perceptual recognition of normal and abnormal findings-may be beneficial in the early months of training of diagnostic radiology residents to hasten achievement of an acceptable perceptual performance. Test films, used in this study as an evaluation technique, may also be useful to assess residents' progress.
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