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Biomedical subjects

H D Weiss

Publications and source records attributed to H D Weiss.

At least 37 records · Page 2Linked to original sources
PubMed1995

[Normal variation of arterial liver supply in mesenterico-celiacography].

Progress in operative techniques in surgery of the upper abdomen necessitates extensive preoperative diagnostic studies. Mesenterico-coeliacography along with CAT-SCAN form the basis for effective operative planning. In the angiography, the clinician is often confronted by variations in the arterial supply of the liver. These variations of the norm which are scarcely mentioned in anatomical textbooks must be carefully taken into consideration by the surgeon. In order to clarify the operative significance of these variations, we have conducted a retrospective study of the angiographies of the truncus coeliacus as well as of the arteria mesenterica superior. We found variations in 25.5% of 204 angiographies. The incidence of deviant and accessory hepatic arteries was 33.8% and of variations in the truncus coeliacus was 6.7%. These variations of the norm are discussed as to clinical and embryological aspects.

Angiography↗
PubMed1995

[Doppler ultrasound monitoring during vascular interventions].

Doppler ultrasound examination as diagnostic device in angiology yields only discontinuous information on flow velocities in vessels during insonation with hand-held probes. Continuous insonation and therefore determination of flow velocities in arteries are necessary to evaluate flow disturbances and changes of flow velocities during radiologic invasive interventions, i.e. implantation of stents, during percutaneous transluminal angioplasty therapy or local lysis. This modification of Doppler ultrasound examination is already used in neurosurgery for permanent monitoring of flow velocities in large brain vessels in one or both hemispheres during therapy. In our institute we developed a probe holder device to fix a miniature Doppler ultrasound probe (8-MHZ pulsed-wave probe) on the skin surface. Therefore continuous insonation during the manipulations is easy to realize. Information about complications such as occlusions, thrombi, emboli and changes in flow velocity is immediately present on the screen. We have monitored 40 patients during radiologic interventional therapy in arteries of the lower limb. Complications during the interventions were detected immediately and could be corrected.

Adult↗
PubMed1995

[Digital picture archiving, processing and communication in diagnostic imaging with a Siemens Network (SIENET): initial results].

The concept of Picture Archiving and Communication System (PACS) in digital imaging offers substantial advantages: better data security, faster access to archived images, simultaneous availability of images at different sites, minimal space demand for archive medium, retrospective image post-processing opportunities and lower costs resulting from reduced film consumption and length of stay. However, practical experiences concerning reliability and efficiency of real PAC networks in radiological departments have to be made yet in order to improve network structure, software design and hardware performance. The ongoing stepwise installation and test of a Siemens PACS (SIENET) at the Department of Radiology at the Medical University of Lübeck will support the introduction of PACS concept into radiological practice.

Computer Communication Networks↗
PubMed1994

[DSA with mechanically injected carbon dioxide. Animal experimental results].

Carbon dioxide was used as an intra-arterial contrast medium by mechanical injection in 10 pigs. 127 angiographic examinations of 114 vascular territories were carried out and 93 were successful. A mechanism providing even gas volumes was chosen to obtain reproducible volume and pressures when using a compressible medium such as gas. Gas pressure is exponentially correlated with volume and volumes of 20-50 cm3 at 1000 mbar adequate for filling various infradiaphragmatic vascular areas. In parenchymatous organs, gas filling is seen only as far as third order arteries. The reason for this is escape of gas through preexisting arteriovenous fistulae into the efferent veins.

Angiography, Digital Subtraction↗
PubMed1994

[Densitometry in suspected preclinical osteoporosis: quantitative computerized tomography versus dual energy roentgen absorptiometry].

The bone mineral density of 85 patients with suspicion of a preclinical osteoporosis was measured at the lumbar spine by using quantitative computed tomography (QCT) in single-energy technique (SEQCT) and dual-energy technique (DEQCT) as well as by using dual-energy X-ray absorptiometry (DEXA). Additionally, the bone density of 63 of these patients was measured at the left femoral neck using DEXA. DEQCT und DEXA of the lumbar spine showed only a moderate correlation (R = 0.75) and differed considerably concerning the classification of the patients as normals or individuals with a mineral deficit when compared with age-matched normals (relative mineral deficit). The DEXA proved to be susceptible to degenerative alterations of the lumbar spine. Because of the extremely low dose of radiation and the good reproducibility the DEXA could nevertheless be recommended as a method for the long-time progress control especially for younger patients. SEQCT and DEQCT showed a very strong correlation (R = 0.98). The SEQCT with its lower dose of radiation should be sufficient for a long-time progress control and in many cases also for the initial diagnostics. Significant but only moderate correlations were found between the bone density at the femoral neck and the DEXA or DEQCT results (R = 0.68 respectively R = 0.63) for the lumbar spine, so that the linear regression did not render any useable approximations. Sufficiently exact information about the mineralization status of a certain skeletal site can only be obtained by direct measurement.

Absorptiometry, Photon↗
PubMed1994

[MR tomography of acute pancreatitis: initial results].

Magnetic resonance imaging (MRI) was evaluated for its potential in assessment of acute pancreatitis compared to computed tomography (CT). 15 patients with acute pancreatitis were examined using a routine protocol including T1- and T2-weighted sequences and a fat-suppressed T1-weighted spin-echo sequence. Gadopentant-Dimeglumin (Gd-DTPA) was given. For comparison, plain and contrast-enhanced CT was performed prior to MRI. MRI proved to be superior to CT in detection of bleeding, duodenitis and ascites. MRI failed to detect concrements. These first results show that, considering the latest development in technology, MRI is not inferior to CT in diagnostic imaging of acute pancreatitis.

Acute Disease↗
PubMed1993

Neural network approach for computer-assisted interpretation of ultrasound images of the gallbladder.

Multi-formatted films of 90 ultrasound examinations of the gallbladder (stones 56 cases, sludge 20 cases, hydrops five cases, normal gallbladder nine cases) have been digitalized and stored in a personal computer. Image data of each examination was processed to extract a 19-dimensional vector that represents the essential diagnostic information of each examination. This vector was evaluated by three different classification algorithms: (1) classical nearest neighbor principle, (2) classical linear discriminant analysis, (3) multilayered backpropagation neural network. The correct classification rate was 64% (58/90) for the nearest neighbor principle, 97% (87/90) for the linear discriminant analysis, and 99% (89/90) for the backpropagation neural network. We conclude that, (1) automated classification of ultrasound images is possible for limited diagnostic problems, (2) a neural network approach can be used successfully for that goal, and (3) the efficiency of the more flexible neural network approach is comparable to large-scale classical methods.

Cholecystography↗
PubMed1993

Insufficient hemodialysis access fistulas: 18 months' experience in laser-supported dilation.

Patients with end-stage renal failure disease frequently develop venous stenoses or occlusions in their hemodialysis access fistulas caused by intimal fibrosis. A complete dilation with high pressure balloons up to 20 atm may be unsuccessful in those cases. We investigated two new pulsed dye laser devices for the ablation of obstructions, which were not adequately treatable with a previous balloon angioplasty. From November 1990 to April 1992 a total of 154 percutaneous transluminal angioplasties (PTAs) of hemodialysis access fistulas were performed. In 23 of them an additive laser angioplasty was necessary. Twenty patients with Cimino fistulas presented 28 stenoses and two occlusions, and three Goretex loops presented all occlusions. Two pulsed dye laser devices emitting at 504 nm and 595 nm wavelength were tested. Technical success was achieved in 22/23 cases, but clinical success was obtained in 20/23 patients because two early reocclusions caused by thrombosis appeared. Five restenoses occurred 2, 3, 10, and in two cases 14 months after angioplasty with a mean follow-up period of 13.5 (5-18) months. Pulsed dye laser ablation in hemodialysis access fistula lesions due to intimal fibrosis is a valuable enrichment of radiological recanalization techniques and an alternative to surgery if stand alone balloon PTA fails.

Angioplasty, Laser↗
PubMed1993

[Thrombotic and thromboembolic occlusions of leg arteries and bypasses. Short-term versus long-term lysis].

Since thrombolytic therapy is less invasive than operative thrombectomy, it is often used as initial treatment for thrombotic or thrombo-embolic occlusions of lower limb arteries or by-passes. We compared four patient groups with acute and subacute occlusions: 1. 19 patients with occluded by-passes treated by rapid lysis using 15.5 (2.5-35) mg rt-PA. 2. 12 patients with by-pass occlusions treated with initial rt-PA in a dose of 6.5 (2.5-12.5) mg followed by prolonged lysis with 5.6 (2.5-10) x 10(6) units of urokinase. 3. 16 patients with arterial occlusions treated by rapid lysis with 15 (2.5-25) mg rt-PA. 4. 14 patients with arterial occlusions given 10.5 (2.5-60) mg rt-PA followed by overnight treatment with 5.9 (2.5-15) x 10(6) units of urokinase. For by-pass recanalisation, prolonged lysis overnight had a success rate of 83% (10/12) which was better than short term lysis with a success rate of 74% (14/19). Similar results were obtained in arterial occlusions with a success rate of 86% (12/14) compared with 69% (11/16). Long term lysis did, however, have significantly more complications. In about one-third of cases further procedures had to be used in addition to lytic therapy.

Aged↗
PubMed1993

[The laser-assisted balloon angioplasty of insufficient hemodialysis-access fistulae].

Patients with end-stage renal failure frequently develop venous stenoses or occlusions in their haemodialysis access fistulas caused by intimal fibrosis. A complete dilation with high pressure balloons up to 20 atm may be unsuccessful in such cases. We investigated two pulsed dye laser devices for the ablation of obstructions, which were not adequately treatable with a previous balloon angioplasty. From 11/90 to 4/92 a total amount of 154 PTAs of haemodialysis access fistulas were performed. In 23 of them additive laser angioplasty was necessary. 20 patients with Cimino fistulas presented 28 stenoses and two occlusions, whereas all the three patients with Goretex loops presented with occlusions. Two pulsed dye laser devices emitted at the wavelengths 504 nm (green) and 595 nm (red). Technical success was achieved in 22/23 cases, but clinical success was obtained in only 20/23 patients, due to two early reocclusions caused by thrombosis. 5 restenoses occurred two, three, 10, and twice 14 months after angioplasty with a mean follow-up period of 13.5 (5-18) months. Pulsed dye laser ablation in haemodialysis access fistula lesions due to intimal fibrosis greatly enriches radiological recanalisation techniques and is a valuable alternative to surgery if stand-alone balloon PTA fails.

Angioplasty, Balloon, Laser-Assisted↗
PubMed1993

[Carbon dioxide as an irrigation medium for percutaneous angioscopy].

Since technical progress has allowed the development of small and flexible endoscopes, percutaneous, transluminal angioscopy promises to be a diagnostic and therapeutic tool. Nevertheless, the main problem is to obtain a satisfactory bloodless visual field. The saline solutions used for this purpose present problems with hypervolaemia, insufficient clearance, and decreased refraction. We investigated a CO2 application system for angioscopy that allows the reproducible injection of variable quantities of gas, pressure, and injection time. In 10 pigs undergoing angioscopy, CO2 was injected through a Swan-Ganz catheter under blockade of the distal aorta. Using a bifemoral approach, the application of gas and the blocking balloon were controlled by an automatic gas injector. The CO2 was injected through the tip of the catheter with a constant flow and a variable pressure and time. The angioscopy procedures were videotaped. With small volumes of carbon dioxide (approximately 50 cm3; 1000 mbar application pressure) a column of gas can be created which, unlike liquids, completely displaces blood from the vessels and allows for several minutes a bloodless inspection of the aorta and the side branches without blood mixture. Carbon dioxide application allows safe and successful percutaneous angioscopy under optimal conditions if the quantities of gas, pressure, and injection time are adjustable. The tested gas injection device fulfills these conditions.

Angioscopes↗
PubMed1991

Post-traumatic migraine: chronic migraine precipitated by minor head or neck trauma.

Minor trauma to the head or neck is occasionally followed by severe chronic headaches. We have evaluated 35 adults (27 women, 8 men) with no prior history of headaches, who developed recurrent episodic attacks typical of common or classic migraine following minor head or neck injuries ("post-traumatic migraine"-PTM). The median age of these patients was 38 years (range 17 to 63 years), which is older than the usual age at onset of idiopathic migraine. The trauma was relatively minor: 14 patients experienced head trauma with brief loss of consciousness, 14 patients sustained head trauma without loss of consciousness, and 7 patients had a "whiplash" neck injury with no documented head trauma. Headaches began immediately or within the first few days after the injury. PTM typically recurred several times per week and was often incapacitating. The patients had been unsuccessfully treated by other physicians, and there was a median delay of 4 months (range 1 to 30 months) before the diagnosis of PTM was suspected. The response to prophylactic anti-migraine medication (propranolol or amitriptyline used alone or in combination) was gratifying, with 21 of 30 adequately treated patients (70%) reporting dramatic reduction in the frequency and severity of their headaches. Improvement was noted in 18 of the 23 patients (78%) who were still involved in litigation at the time of treatment. The neurologic literature has placed excessive emphasis on compensation neurosis and psychological factors in the etiology of chronic headaches after minor trauma. Physicians must be aware of PTM, as it is both common and treatable.

Adolescent↗
PubMed1991

Calcium antagonists and atherosclerosis.

Numerous trials have used calcium antagonistic substances to inhibit or prevent genesis and progression of atherosclerosis, as well as disintegration of intimal proliferates and calcium deposition in atheromas or in matrix tissue of artery walls. In experimental models, various components involved in the development of atherosclerosis can be influenced by calcium antagonists. Transendothelial transport through interendothelial spaces and through the endothelial cells are sensitive to calcium antagonists of various types. Some drugs with calcium antagonistic properties are capable of inhibiting the development of stenosing proliferates caused by ballooning or other types of local artery wall stimulation. With cultures of cells obtained from normal and atherosclerotic arteries, insights into the mechanisms are possible by which various calcium antagonists influence the development and the progression of atherosclerosis.

Animals↗