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Biomedical subjects

H Daisley

Publications and source records attributed to H Daisley.

At least 19 recordsLinked to original sources
PubMed2000

Maternal mortality following the use of misoprostol.

Three cases of maternal death following the use of misoprostol are presented. In two of the cases the drug was used to procure illegal abortion, and in the third case maternal death occurred following uterine rupture, after misoprostol was used clinically for induction of labour. A brief review of the usage of misoprostol is presented, including recommendations for its safe use.

Abortifacient Agents, Nonsteroidal↗
PubMed1999

Acute myocarditis following Tityus trinitatis envenoming: morphological and pathophysiological characteristics.

The clinicopathological features of four cases of scorpion envenoming by Tityus trinitatis are presented. The cardiac histopathology is recorded in the two fatal cases. The pathology of the acute myocarditis was a mixed picture of a toxic myocarditis and coagulative myocytolysis. These cardiac lesions are also seen in catecholamine induced cardiotoxicity and lend support to the theory that an adrenergic surge follows scorpion envenoming. A brief review of scorpion envenoming syndrome is undertaken in the light of these findings.

Acute Disease↗
PubMed1999

Homicide by paraquat poisoning.

We report on two cases of homicide by paraquat poisoning. Both cases occurred in children and the common clinical presentations were gastrointestinal ulceration and acute respiratory distress, with pneumomediastinitis. Bullous emphysema was a common autopsy finding. Physicians and pathologists should be aware of these findings, for they are almost diagnostic of acute paraquat poisoning.

Autopsy↗
PubMed1999

High rates of paraquat-induced suicide in southern Trinidad.

The suicide rate in Trinidad and Tobago is much greater than that of its English-speaking Caribbean neighbors. Many of these suicides are paraquat induced. This research reviewed the deaths due to suicide in the area with the greatest agricultural activity in Trinidad for 1996 and identified, for further demographic and etiological investigation, cases in which paraquat was ingested as the agent of suicide. Of 48 cases of suicide for the year, 39 (81.3%) were due to paraquat poisoning. The incidence of paraquat-induced suicide was 8.0 per 100,000. Among the males, 47.8% were in the age group 25-34 (p < 0.001), and among the females 50.0% were in the 15-24 age group (p < 0.05). Family-of-origin disputes were the most frequently cited precipitant, followed by marital problems. Individuals of East Indian origin accounted for 89% of the suicide victims (p < 0.001). When compared with suicide by other methods in the country, these findings confirm that paraquat poisoning is a significant means of suicide in Trinidad and that young East Indian individuals are particularly vulnerable.

Adolescent↗
PubMed1999

Severe aplastic anaemia--complete response to antilymphocyte globulin and cyclosporin.

Severe aplastic anaemia is uniformly fatal unless treated with immunosuppressive therapy or bone marrow transplantation. The latter is curative in 65% of patients and is the treatment of choice in children and young adults. Antilymphocyte globulin (ALG) and cyclosporin may be used successfully in the absence of an HLA matched sibling donor. We report the case of a twelve-year-old boy with severe aplastic anaemia who received immunosuppressive treatment with ALG and cyclosporin and is alive and well three years and six months post treatment.

Anemia, Aplastic↗
PubMed1999

Forensic analysis of acute fatal poisonings in the southern districts of Trinidad.

A prospective autopsy study was undertaken at General Hospital in San Fernando, Trinidad, to analyze deaths that occurred from poisoning during 1996 and 1997. During that period 105 deaths occurred from acute poisoning. The major poisons used were: paraquat (80 cases), organophosphate/carbamate insecticides (10 cases), and anti-psychotic drugs (6 cases). Much less frequently, battery acid, ETHREL[Ethephon; (2-chloroethyl)phosphonic acid], phenols, ethanol, kerosene and flavine were the agents of choice. Suicide accounted for 99 (94.29%) deaths. Of these, 44.44% occurred in the 10-29 y-age-group. Ingestion of paraquat seems almost always fatal, since the large volumes ingested make treatment universally ineffective. Aspiration pneumonitis (100% of cases), and pneumothorax with pneumomediastinum (18.75% of cases), were remarkable autopsy findings in those dying from paraquat poisoning, while asphyxia due to respiratory paralysis was the mode of death from pesticide ingestion. Efforts to prevent suicide by poisoning may be more useful than treatment protocols.

Adolescent↗
PubMed1998

Paraquat poisoning.

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Agricultural Workers' Diseases↗
PubMed1997

Cardiac involvement with lymphoma/leukemia: a report of three autopsy cases.

The clinicopathological findings in two patients with ATL and one patient with promyelocytic Leukemia affecting the heart are described. All three cases tested positive for HTLV-I while one of the ATL cases was also positive for HIV. Cardiac infiltrate in the ATL cases varied from microscopic focii in one case to macroscopic infiltration mimicking myocardial infarction in the other case. There were microabscesses in the myocardium in the case afflicted with promyelocytic Leukemia. All three cases had extensive malignant disease with multiple organ infiltration. There was no ante-mortem manifestation of cardiac involvement in any case. The cardiac dimensions were all within the normal range. The possible pathophysiology of cardiac involvement with Lymphoma/Leukemia is discussed.

Adult↗
PubMed1993

HTLV-1 revisited.

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Cross-Sectional Studies↗
PubMed1993

Fatal metastatic calcification in a patient with HTLV-1-associated lymphoma.

Metastatic calcification of the heart, lungs and kidneys is described in a 42-year-old male who had an HTLV-1-associated lymphoma. This fatal complication of HTLV-1-associated lymphoma has been infrequently reported, and the case in question is the first to be recorded in the Caribbean, where HTLV-1 is common. Aggressive therapy of hypercalcaemia should be instituted early in its genesis in these lymphomas, so as to avoid its fatal outcome.

Adult↗
PubMed1991

Screening for HTLV-1 in healthy blood donors in Trinidad and Tobago, West Indies.

Of 1089 healthy blood donors screened for HTLV-1 using ABBOTTS HTLV-1 EIA: 18 (1.7%) were positive; and 16 (1.5%) were confirmed positive using HTLV-1/11 Cambridge Biothec Western Blot method. HTLV-1 antibodies were found amongst the major ethnic groups, viz. Africans, 11 cases (68.75%) and East Indians 4 cases (25%). The mean age of the donors who tested positive for HTLV-1 was 30.75 years; and the male to female ratio was 4.3:1.

Adult↗
PubMed1991

Suicide by poisoning.

An epidemiological evaluation was conducted on 270 patients who died at the General Hospital, Port-of-Spain after presenting with deliberate self-poisoning between January, 1986 and June, 1990. The cause of death was confirmed by autopsy and toxicological analysis. Epidemiological variables of age, sex, race, precipitating factors and types of poison used were assessed. It was found that the male to female ratio was 2.7:1. East Indians accounted for 54.4%, Africans 42.0%, people of mixed ethnic origin 3% and Caucasians 0.6%. The majority of cases (52.6%) were seen in the age group 11-34 years. "Lovers' quarrels" (35.4% of cases), psychiatric illness (27.8% of cases) and family disputes (27% of cases) were reported as the most frequent precipitating events in suicide. East Indians predominated in those suicides precipitated by "lovers' quarrels" and family disputes, accounting for 63.2% and 58.9% of these cases, respectively; while for those suicides in which psychiatric illnesses were the main precipitating event. Africans were represented by 53.3% and East Indians 45.3%. Depression was the most common psychiatric illness diagnosed. Paraquat was the most popular poison used in 63.7% of the suicidal cases, and other agrochemicals were used in 20% of cases.

Adolescent↗