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H Date

Publications and source records attributed to H Date.

134 records · Page 8Linked to original sources
PubMed1984

[Antibacterial activity of MT-141 against anaerobic bacteria].

In vitro and in vivo antibacterial activities of MT-141, a new cephamycin, against anaerobic bacteria were compared with those of cefmetazole (CMZ), cefoxitin, cefotaxime, ceftizoxime, latamoxef and cefazolin to obtain the following results. MT-141 showed high activity against a wide variety of anaerobic bacteria including B. fragilis and C. difficile except for Eubacterium lentum, E. aerofaciens and B. furcosus. Antibacterial activity of MT-141 against anaerobic bacteria was almost independent of inoculum size, medium, pH and serum addition. In vitro development of resistance of MT-141 against P. variabilis and B. fragilis was comparable to that of CMZ. Successive parenteral administration of MT-141 into mice did not cause abnormal proliferation of C. difficile. MT-141 showed excellent therapeutic effect against experimental subcutaneous abscess in mice caused by B. fragilis.

Animals↗
PubMedDate not supplied

Pial arterial pressure in cats following middle cerebral artery occlusion. 1. Relationship to blood flow, regulation of blood flow and electrophysiological function.

In lightly anesthetized cats, the left middle cerebral artery was occluded using a transorbital approach. Pial arterial pressure was measured with a feedback-controlled micropressure recording system in the territory of the occluded artery, and compared with changes of cortical blood flow, cortical steady potential and cortical EEG activity. After middle cerebral artery occlusion pial artery pressure fell from 56.2 +/- 1.6 to 7.8 +/- 0.4 mm Hg; during the following two hours it again slowly rose to about 15 mm Hg. Cortical heat conductance, as a measure of blood flow, decreased from 15.1 +/- 0.2 to 11.9 +/- 0.2 X 10(-4) cal X cm-1 X sec-1 X degrees C-1, and remained at this level throughout the observation period. Cortical steady potential shifted by 9.1 +/- 0.7 mV towards negativity, and EEG amplitude was reduced by about 50%. Pial arterial pressure correlated with blood flow, cortical steady potential and EEG amplitude, but not with EEG frequency. Autoregulation and CO2 reactivity of blood flow were disturbed after middle cerebral artery occlusion. Calculation of extra- and intracortical vascular resistances revealed that this disturbance was entirely due to intracortical vasoparalysis whereas the collateral vessels supplying the ischemic territory continued to react to both pressure and CO2 changes. Maintained vascular reactivity of collateral vessels, therefore, is a decisive factor for the efficiency of therapeutic blood flow improvement after acute middle cerebral artery occlusion.

Animals↗
PubMedDate not supplied

Systemic necrotizing vasculitis with renal involvement accompanied by remarkable eosinophilia: a case with overlapping features of polyarteritis nodosa and allergic granulomatous angiitis.

A 71-year-old woman was clinically suspected of allergic granulomatous angiitis (AGA) because of preceding allergic diseases including bronchial asthma, remarkable eosinophilia (14,300/mm3), mononeuritis multiplex, positive rheumatoid factor, elevated serum immunoglobulin E, and eosinophilic inflammation of the kidney. Autopsy findings, however, were characterized of polyarteritis nodosa (PAN). Necrotizing angiitis was present in several organs except for the lung; focal and segmental glomerular lesions with crescent formation were observed in the kidney, and granuloma formation was not found. This case may be an intermediate type between PAN and AGA (an overlap syndrome) and provide useful information on the clinical entities of systemic necrotizing vasculitis.

Aged↗
PubMedDate not supplied

Moyamoya syndrome in young children: MR comparison with adult onset.

PURPOSE: To clarify whether there were any differences in MR appearance between the childhood and the adult moyamoya syndromes. METHOD: We compared the cranial MR findings in four children under the age of 6 who had moyamoya syndrome with previously documented adult cases. RESULTS: Moyamoya syndrome in younger children exhibited a significant increase in cortical and subcortical infarction, and a decreased incidence of deep white matter infarction in the centrum semiovale and basal ganglia, in contrast to adult cases. There were no remarkable differences between these two groups of moyamoya cases with regard to the occlusive changes of the internal carotid and middle cerebral arteries, or to the flow void sign on MR. CONCLUSION: These differences in the sites and frequencies of infarctions between the childhood and the adult moyamoya syndromes observed on MR might reflect differences in the cerebral circulation.

Adult↗
PubMedDate not supplied

Synchronous primary lung cancer presenting with small cell carcinoma and non-small cell carcinoma: diagnosis and treatment.

Synchronous primary lung cancer (SPLC) occurs in up to 0.5% of patients with lung cancer. Among SPLC cases, coexistence of small cell carcinoma (SCLC) and non-small cell carcinoma has been reported in a very small fraction. Futhermore, there have been no reports discussing treatment and prognosis of SPLC presenting with SCLC and NSCLC. We report on two cases of SPLC presenting SCLC in limited stage and operable NSCLC. One patient developed synchronously SCLC and adenocarcinoma of the lung, while the other SCLC and squamous cell carcinoma of the lung. The clonal origin of these synchronous lung cancers was evaluated using immunohistochemical and polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analyses. Both of the patients were diagnosed based on transbronchial lung biopsy (TBLB) and mediastinoscopic biopsy. They were successfully treated with chemoradiotherapy and adjuvant surgery, and are now doing well without any signs of tumor progression for about one year. In both cases, a response of mediastinal lymph node for concurrent chemoradiotherapy was quite different from that of the mass in the lung field. In case 2, p53 mutation was observed in the SCLC tissue, but not in the NSCLC tissue by PCR-SSCP. In both cases, carcinoembryonic antigen was documented in the NSCLC tissue, but not in the SCLC tissue by immunohistochemical staining. This report indicates the importance of the accurate diagnosis of SPLC by employing TBLB and/or media-stinoscopy for the optimal treatment of patients having SPLC presenting with SCLC and NSCLC. Diagnostic criteria and standard treatment of this disease should be established.

Adenocarcinoma↗