PubMed Health⌕ Search

Biomedical subjects

H Deckart

Publications and source records attributed to H Deckart.

At least 19 recordsLinked to original sources
PubMed1995

[Radiation exposure from nuclear medical procedures in the former DDR].

From 1978-1988 central records were kept of nuclear medical in vivo and in vitro examinations and of treatments with radiopharmaceuticals in the former GDR. On the basis of ICRP publications No 60 the effective dose, the collective effective dose, and the radiation risk were assessed. Twenty-six different nuclear medical examinations were used in the calculations. The most frequent examinations were thyroid scintigraphy with 99mTc-pertechnetate and renography with 131I-hippurate. 131I thyroid examinations decreased by a factor of 4 in the GDR during the period considered. Though the number of patients increased from 1978-1988 by about 55%, a continuous reduction of collective effective dose from 607 to 377 manSv could be achieved. The average effective dose was reduced from about 5.5 to 2.2 mSv. The radiation risk decreased by a factor of 2.5.

Germany, East↗
PubMed1993

Prognostic factors in medullary thyroid carcinoma: evaluation of 741 patients from the German Medullary Thyroid Carcinoma Register.

A retrospective study of 741 patients with medullary thyroid carcinoma diagnosed between 1967 and 1991 was carried out by members of the German Medullary Thyroid Carcinoma Study Group to evaluate prognostic factors. A total of 559 patients (75%) were considered to have sporadic disease, and 182 (25%) had the familial type. The sex ratio (male to female) was 1:1.4 in sporadic disease patients, and the mean age at diagnosis was 45.9 years (range 5-81 years). For familial disease patients the sex ratio was 1:1.1, and the mean age at diagnosis was 33.4 (range 5-77 years). The follow-up time for 630 patients ranged from 1 month to 20.8 years (mean 13.0 years). The overall adjusted survival rate was 86.7% at 5 years and 64.2% at 10 years. In a univariate analysis the stage of disease at diagnosis, age, sex, and type of disease (sporadic, familial) were relevant prognostic factors, with a better prognosis for young female patients with familial disease and diagnosed at an early stage. In a multivariate proportional hazards analysis, the difference in the survival rate of patients with familial disease versus those with the sporadic form disappeared, while prognostic information provided by age and sex was still significant. The poorer prognosis of patients with sporadic medullary thyroid carcinoma may be related to the patients' older age at detection and more advanced tumor stage at diagnosis. There seems to be no difference in biological behavior between tumors of the sporadic and those of the familial type.

Adolescent↗
PubMed1990

[The validity of selected nuclear medicine imaging procedures (brain, skeletal, and hepatobiliary diagnosis)].

In a retrospective study we tested several scintigraphic investigations for a total of 2,014 patients. As reference we used the results of biopsy, autopsy or the epicritic final diagnosis before emission, summing all clinical signs as well as the results of additional alternative methods and other imaging methods. Criteria of validity (sensitivity, specificity, diagnostic accuracy) are used in a consistent manner. Brain perfusion scintigraphy detected acute cerebral perfusion disorder with a sensitivity of 0.87, differentiating for reversible and irreversible lesions. Carotid angiography had the same diagnostic validity. Because there is no loss of brain substance, the validity of CT and static brain scintigraphy was lower. Skeletal scintigraphy was highly sensitive for the detection of primary and secondary bone tumours as well as for the detection of inflammations and occult fracture. RHS-scintigraphy of the liver, presently used for tumour and metastasis diagnostics after sonography and CT, had a sensitivity of 0.79. It was more sensitive for detecting inflammatory RHS-liver disease (sensitivity 0.95). Biliary scintigraphy was seen under the surgical aspect only for selected questions. It was sensitive for the detection of biliary cyst disorder and the elucidation of complaints after biliary tract sanitation (sensitivities 0.92 and 0.84) and for the detection of duodenogastric reflux (0.7), but was of limited diagnostic value for the differentiation of hepatocellular and obturation icterus with a sensitivity of 0.5.

Bile Duct Diseases↗
PubMed1990

A 5 year interdisciplinary control of iodine deficiency in the GDR.

The interdisciplinary iodine prophylaxis in the GDR is a successful measure for control of ID. The iodization of nearly all the salt is planed perhaps with reduction of the iodine concentration. However, next further steps may be done in cooperation of the Interdisciplinary Iodine Commission with the "Arbeitskreis: Jodmangel" in the FRG.

Germany, East↗
PubMed1990

[Incidence of autonomy and immune hyperthyroidism before and following preventive use of iodized salt in the Berlin-Brandenburg area].

The incidence of hyperthyroidism was observed in the area of Berlin (1.2 million inhabitants) and in a rural district in the geographical region of the "Mark Brandenburg" (48.115 inhabitants) during the period from 1975 und 1989. This area is characterized with a iodine deficiency grade II (WHO). In 1985 an iodine salt supplementation was introduced by law. The period before iodine salt supplementation 1975-1985 was compared to the period after iodine prophylaxis: there was an increase in hyperthyroidism in the Berlin-area by the ratio 1:3.1 and 1:2.8 (1975-83 compared to 1988 and 1989), in the rural district by 1:1.7 (1980-1985 compared to 1986/87). The ratio autonomy (non immunogenic form) to immunogenic etiology was 1:12 (1977-83), and changed to 1:1.45 in 1988 and 1:16.3 in 1989 after iodine supplementation. The sex ratio male:female was 1:10 before, and 1:6.8 after prophylaxis for hyperthyroidism in total, in autonomy the ratio was observed as 1:12 before and 1:7.7 (1988), 1:4.7 (1989) after supplementation, in immunogenic hyperthyroidism 1:10 unchanged in the early and late period of observation. The increase of hyperthyroidism after iodine prophylaxis correlated well with the consumption of thyrostatic drug Thiamazol (Methimazol) for the whole country. The defined daily dose (DDD)/1000 inhabitants/day increased during the observation time from 0.5 (1984), 0.55 (1985), 0.66 (1986), to 1.47 (1987), 1.26 (1988) and 0.81 (1989). The results are compared and discussed with reports from USA, Iceland, Great Britain, Denmark, Italy and Tasmania. During the period of seven years (1980-87) in the rural district a seasonal dependence of onset in hyperthyroidism was observed in spring time between May and June only in immunogenic hyperthyroidism, despite in thyroidal autonomy the disease began throughout the year without a seasonal peak.

Berlin↗
PubMed1988

[Imaging procedures in the diagnosis of thyroid diseases].

The image-producing examination techniques used in the morphological diagnostics of the thyroid gland are demonstrated. Their application must deliberately be done dependent upon the clinical findings and the therapeutic questioning. For the various thyropathies in this sense a diagnostic step programme is reported with the aim of a rational application of the individual techniques. These are conventional x-ray diagnostics, computed tomography, ultrasound tomography, scintigraphy (fluorescence scintigraphy), fine needle aspiration biopsy and cytology. Most frequently a combination of ultrasound and scan is recommended for the combined assessment of morphology and function.

Diagnostic Imaging↗
PubMed1987

Radiopharmacokinetics and radiation dose from 99mTc-HM-PAO (preliminary report).

Whole body retention measurements were performed in volunteers after i.v. injection of 99mTc-HM-PAO (Ceretec). The organ accumulation was measured in mice and data were transferred to standard man according to ICRP. Absorbed dose calculations were made with these data by using the concept of absorbed fractions (MIRD method). In man, the whole body retention and the retention in the brain could be calculated by direct measurement, absorbed doses to the other organs could only be derived from animal data. The absorbed dose to the brain derived from human data (10.3 microGy/MBq) is greater by a factor of 2 than that derived from animal data. The highest absorbed dose was received by the thyroid (24.4 microGy/MBq), the absorbed dose to the ovaries, testes and whole body ranged from 2.8 to 4.2 microGy/MBq.

Animals↗
PubMed1987

Radiopharmacokinetics and radiation absorbed dose calculations from 131I-meta-iodobenzylguanidine (131I-MIBG).

In connection with clinical 131I-MIBG studies of patients with suspected pheochromocytoma and adrenomedullary hyperplasia quantitative biokinetic data have been collected in order to improve the present estimations of absorbed dose to various organs and tissues. Whole-body profiles as a function of time were measured with a whole-body counter. The retention in the total body and in the thyroid gland could be derived from the measured whole-body profiles by summing up the corresponding values. The retention of 131I-MIBG could not be exactly measured for further organs from the whole-body profiles in man. For this reason animal studies were performed with mice. The biokinetic animal data were transferred to man in form of the cumulative activity for the various organs. The mean absorbed dose for selected organs per injected activity unit was calculated using the concept of absorbed fractions (MIRD method) taking into account the radioactivity within the remaining body. Except for both the adrenal medulla and the thyroid gland the absorbed doses for all the other selected organs are in a range from 0.108 mGy MBq-1 for the testes to 0.176 mGy MBq-1 for the lungs. The absorbed dose to the thyroid gland amounts to the considerable value of 5.69 mGy MBq-1 although the thyroid gland was blocked. The greatest absorbed dose was estimated for the normal adrenal medulla with 18.67 mGy MBq-1.

3-Iodobenzylguanidine↗