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H Degen

Publications and source records attributed to H Degen.

7 recordsLinked to original sources
PubMed1989

[Animal welfare requirements for the raising and breeding of pheasants].

The different husbandry systems for raising pheasants are introduced and discussed. In particular, size and shaping of aviaries are described. Some remarks are made on the critical points, e.g. individual space, stocking density, planting of aviaries, and feeding of animals. Special emphasis is put on the problem of feather picking, which may lead to a struggle for existence of the owner. Existing methods for prevention of feather picking are introduced and assessed. Finally, an assessment with respect to animal welfare is made, revealing that, in general, raising of pheasants is not in conflict with animal welfare regulations. Nevertheless, in some aspects improvements are recommended, and some of the husbandry systems and manipulations can not be tolerated from the animal welfare point of view. Further research is needed to ensure a species specific raising of pheasants on a scientific base.

Animal Husbandry↗
PubMed1982

[On the pharmacokinetics and bioavailability of paracetamol in suppositories for paediatry (author's transl)].

In a comparative study on the pharmacokinetics of two paracetamol suppository preparations (A = Kinder-Tylenol, B = reference compound as a commercial preparation), serum levels were determined in 10 healthy male volunteers between 23 and 32 years over 12 h at 11 measurement points. Aim of the trial was to examine the bioavailability, the absorption and elimination rate as well as the distribution volume for both preparations. After application of both suppository preparations the serum levels revealed that the absorption from prep. A was more than twice as fast (k1 = 0.762 h-1) as that from prep. B (k1 = 0.348 h-1), resulting in an obviously higher maximum blood level. The bioavailability values are also higher when prep. A is administered (123% versus prep. B).

Acetaminophen↗
PubMed1979

[Animal experiments with 99mTc-diethyl-HIDA in acute complete bile duct occlusion (author's transl)].

In order to establish whether a complete obstructive jaundice can abolish the accumulation of diethyl-HIDA (EHIDA) in the liver parenchyma, the common bile duct was ligated in 14 mongrel dogs. Before as well as at regular intervals after ligature of the common bile duct, a sequence scintigraphy was performed with 2 mCi 99mTc-EHIDA. For evaluation, time-activity curves (Tmax, T1/2), and analogue scintigrams as well as laboratory parameters were used for assessment. Up to seven weeks after ligation of the common bile duct, there was a marked accumulation of EHIDA in the liver parenchyma. The relative liver uptake (liver/background ratio) fell from 8.9 to 2.7, whereas conversely the cholestasis indicators aP and bilirubine rose markedly. Tmax did not show any significant alterations, whereas T1/2 was prolonged from about one week after ligation. Because of the duct ligation, there was no excretion of activity into the intestines. Immediately after ligation of the common bile duct, the gallbladder was shown up as a "hot" area in which the majority of the applied activity appeared from about one hour p.i. Begining with the fifth to the seventh day after ligation, the gallbladder was seen as a "cold" area in the liver paraenchyma. Bilirubine and aP were raised by about 50 times the initial value. With longer lasting cholestasis, the scintigram no longer altered whereas bilirubine and aP rose further. Histological examination after ligation for more than five weeks showed slight alterations as a whole. Gamma-GT and in particular GPT were likewise slightly raised compared to bilirubine and aP. The conclusion was drawn from this that the good accumulation of EHIDA in the liver parenchyma which is to be observed without exception even in cholestasis lasting for several weeks could be explained by a relatively slight hepatocellular damage. Only when there is a consecutive parenchymal damage in extrahepatic jaundice, accumulation of EHIDA in the liver can be abolished.

Acute Disease↗