Biomedical subjects

H Donica

Publications and source records attributed to H Donica.

12 recordsLinked to original sources

PubMed1996

[Biochemical changes in extracellular matrix components of the amniotic sac during its premature rupture].

In the fetal membranes that have ruptured 12 hours before onset of the labour the tissue collagen content was lower than in control accompanying by similar local collagenase and elastase activity. These results excluded the inflammatory process as the main cause of prelabour preterm rupture of membranes (PPROM). The analysis of the collagen fractions taken from the site of rupture and the location close to umbilical cord indicates that in PPROM there are changes in posttranslational collagen molecule modification.

Adult↗

PubMed1996

[Hydroxyproline urine excretion--potential marker of cervical ripening?].

Urinary hydroxyproline excretion does not change significantly within last two weeks of gestation among 89 healthy patients. Decreased hydroxyproline concentration found in cervices of pregnant women in the course of labor has not been accompanied by increased urinary excretion of this particular amino acid.

Biomarkers↗

PubMed1996

[Tissue levels of EGF and collagen in ovaries of women].

Tissue EGF concentration as well as collagen content were investigated in ovarian homogenates from both menstruating and menopausal women. EGF concentration was found to be higher, but not significant, in postmenopausal women, whereas total collagen as well as forms soluble in acetic acid and in this acid with pepsin were slightly higher in women with normal menstrual cycle. There were statistically significant negative correlations between above mentioned forms of collagen as well as ovarian EGF concentration in this group of patients. The potential role of epidermal growth factor in modulation of ovarian function and extracellular matrix remodelling within human ovary is discussed.

Adult↗

PubMed1994

Solcoseryl prevents early postradiation changes in the lungs.

The aim of the study was to test the influence of Solcoseryl on early postradiation changes in the lungs of rats. The chests of the rats were irradiated with Co-60, fractional dose 250 cGy/DT, total dose 2500 cGy/DT. Solcoseryl was given intraperitoneally in quantities of 0,1ml daily, during 60 days of the experiment. Morphological examinations of the lungs revealed that Solcoseryl decreased significantly the effects of early postradiation damage of the respiratory organ in rats.

Actihaemyl↗

PubMed1993

Female urinary stress incontinence in terms of connective tissue biochemistry.

The role of connective tissue in the aetiology of female stress incontinence has been investigated. Collagen content and extractability as well as estrogen receptor concentration in vesico-vaginal fascia were measured after small tissue biopsies had been obtained during vaginal repair surgery in cases of urinary incontinence. The mean concentration of estrogen receptor in vesico-vaginal fascia among incontinent women was 49.4 +/- 14.8 fmol/mg of protein as compared to 29.6 +/- 13.1 in continent control group (P < 0.03; t-test). The mean hydroxyproline concentration in vesico-vaginal fascia of incontinent women was 13.8 +/- 2.6 micrograms/mg wet weight, whereas in the control group it was significantly higher 20.6 +/- 2.4 (P < 0.001). The role of connective tissue components in the aetiology of female stress incontinence is discussed.

Biomechanical Phenomena↗

PubMed1991

Cardiovascular diseases risk factors in male population from mining vocational schools of the Lublin Coal Basin.

Contrary to certain industrial countries which secure an impressive decrease in coronary heart mortality, Poland has had, especially in the last decade, the significant increase of morbidity and mortality caused by cardiovascular diseases. Although this phenomenon concerns mainly the middle-age mean groups, special care for the whole population should be undertaken. The successful way to decrease the death rate and morbidity attributed to coronary heart disease (CHD) are the long-term prevention programs as for example Multiple Risk Factor Intervention Trial, Belgian Heart Disease Prevention Project, Lipid Research Clinics Coronary Primary Prevention Trial and others. Because there is some evidence that certain risk factors occur also among children, it seems that the effectiveness and efficacy of such prevention programs may be increased when started in the young population.

Adolescent↗

PubMed1990

[Risk factors of coronary artery disease in males during a 3 year follow up based on a cohort study in a selected region of Lublin].

To assess changes in risk factors of coronary artery disease, examinations which had been performed in 1981 and 1982 were repeated in males aged 40-59, inhabitants of the district "Czechów" in Lublin. The study was based on Polish Experiment of Coronary Disease Multifactor Prevention assumptions 112 of 203 males investigated in 1981, 1982 underwent repeated examination (attendance rate - 55%). Statistical analysis was performed only in twice examined subjects. Significant increase of blood pressure, body weight, total serum cholesterol and uric acid concentration was stated in comparison with their respective initial values. Significant decrease of HDL-cholesterol and no changes in serum triglycerides concentration were observed. The only positive stated alteration was a lower percentage of tobacco smokers. Diagnosis of coronary artery disease remained unchanged despite of increased risk factors levels (increase of mean Rose's index score from 5 in initial examination to 6.5 in a control one). This high increase in risk factors occurrence allows an unfavourable prognosis for future incidence of coronary artery disease and also demands to undertake vigorous prevention.

Adult↗

PubMed1988