Biomedical subjects

H Druid

Publications and source records attributed to H Druid.

21 records · Page 2Linked to original sources

PubMed1989

Reduction of renal edema by heparin in postischemic renal damage.

Rats were subjected to unilateral renal artery clamping for 60 min and contralateral nephrectomy. 125I-labelled fibrinogen and 131I-labelled albumin were injected intravenously 24 h before the experiment. A significant increase in the fibrinogen and albumin content and weight was found already 5 and 15 min after reflow. Rats given heparin (2,000 IU/kg body weight) 5 min before clamping and killed 15 min after reflow showed significantly smaller increases in these values than rats given saline. Morphological studies showed fibrin deposition in Bowman's space, tubules and peritubular capillaries. The results indicate that fibrin deposition occurs and is of importance in the development of renal edema in this type of renal damage.

Animals↗

PubMed1988

Fibrin deposition in the kidney in post-ischaemic renal damage.

To investigate whether fibrin deposition in the kidney occurs in ischaemic acute renal failure, rats were subjected to a left renal artery occlusion (RAO) for 1 h and contralateral nephrectomy. The animals were killed 0, 5, 15 and 60 min after re-establishment of the circulation. Kidney tissue was snap-frozen for immunofluorescence microscopy and scanning electron microscopy, and immersion-fixed for light microscopy and transmission electron microscopy. Immunofluorescence studies showed small amounts of immune reactive fibrinogen/fibrin deposits in the peritubular capillaries. Substantial amounts of fibrinogen/fibrin positive material was observed in Bowman's space and in the tubular lumina. Scanning electron microscopy of freeze-dried tissue disclosed granular and fibrillar material in Bowman's space. A temporary enlargement of Bowman's space was noted; it may have been caused by tubular obstruction. No deposits were found in the control (right) kidneys and in kidneys of heparinized rats subjected to RAO. The results indicate that fibrin deposition occurs in the ischaemic model of acute renal failure in rat, both intravascularly and in the urinary space. Its importance for the development of renal functional impairment remains to be studied.

Acute Kidney Injury↗

PubMedDate not supplied

Fatal seizures associated with trimipramine poisoning.

The present report describes a witnessed, fatal attack of seizures. Very high levels of trimipramine were found in the blood collected at autopsy. The cause of death would most likely have been misinterpreted as a suicidal intoxication if the attack had not been witnessed. Conversely, if toxicologic examination had not been undertaken, the fatality would probably have been registered as epilepsia.

Cause of Death↗